1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone

Product Name: 1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
CAS No.: 511-26-2
Chemical Name: 1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
Synonyms: MAP4343;Pregn-5-en-20-one, 3-methoxy-, (3β)-;5-Pregnen-3B-ol-20-one-17a,21,21,21-d4 3-Methyl Ether;1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone;inhibit,microtubule-associated,Microtubule/Tubulin,Pregnenolone,MAP2,tubulin,polymerization,neurites,MAP 4343,MAP4343,Inhibitor,MAP-4343,protein
CBNumber: CB01260975
Molecular Formula: C22H34O2
Formula Weight: 330.5
MOL File: 511-26-2.mol

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1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone Property

Melting point:: 123.5°
alpha: D18 +18° (c = 1.085 in chloroform)
Boiling point:: 426.6±45.0 °C(Predicted)
Density: 1.04±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 25 mg/mL (75.64 mM)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0027351
Product name: MAP4343
Packaging: 5mg
Price: $100
Updated: 2021/12/16

ChemScene

Product number: CS-0027351
Product name: MAP4343
Packaging: 10mg
Price: $170
Updated: 2021/12/16

ChemScene

Product number: CS-0027351
Product name: MAP4343
Packaging: 25mg
Price: $350
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0016445
Product name: PREGNENOLONE METHYL ETHER
Purity: 95.00%
Packaging: 5MG
Price: $499.04
Updated: 2021/12/16

ChemScene

Product number: CS-0027351
Product name: MAP4343
Packaging: 100mg
Price: $900
Updated: 2021/12/16

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1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone Chemical Properties,Usage,Production

Biological Activity

MAP4343 is a 3-methyl ether derivative of Pregnenolone. It binds to microtubule-associated protein 2 (MAP2) in vitro, stimulates the polymerization of tubulin, enhances neurite extension and protects neurons from neurotoxic agents.

in vitro

MAP4343 (40 μM; 15 or 30 min) stimulates microtubule polymerization in vitro. It stimulates nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells.

in vivo

MAP4343 (12 mg/kg; daily sc for 28 d) improves the recovery of locomotor function after spinal cord injury (SCI) in rats.
MAP4343 (4 mg/kg; daily sc for 6 d) increases MAP2 levels in spinal cord after SCI in rats.
MAP4343 (4 mg/kg; daily sc for 6 d) increases the size of lumbar spinal motoneurons' dendrite arbours after SCI in rats.

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Animal Model:	Adult Sprague-Dawley male rats with spinal cord injury
Dosage:	12 mg/kg
Administration:	Daily sc for 28 days
Result:	Increased the number of animals able to walk with weight-supported plantar steps. Showed forelimb-hindlimb coordination at the end of the study.

1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone Suppliers

China 19 India 1 United States 2 Global 22

Shanghai EFE Biological Technology Co., Ltd.

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TargetMol Chemicals Inc.

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Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd

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511-26-2, 1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanoneRelated Search:

1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone

MAP4343

Pregn-5-en-20-one, 3-methoxy-, (3β)-

5-Pregnen-3B-ol-20-one-17a,21,21,21-d4 3-Methyl Ether

inhibit,microtubule-associated,Microtubule/Tubulin,Pregnenolone,MAP2,tubulin,polymerization,neurites,MAP 4343,MAP4343,Inhibitor,MAP-4343,protein

511-26-2