2-Methoxyquinoline-3-boronic acid
- Product Name
- 2-Methoxyquinoline-3-boronic acid
- CAS No.
- 886853-93-6
- Chemical Name
- 2-Methoxyquinoline-3-boronic acid
- Synonyms
- 3-Borono-2-methoxyquinoline;2-Methoxyquinoline-3-boronic acid;(2-methoxy-3-quinolyl)boronic acid;2-Methoxyquinolin-3-ylboronic acid;(2-methoxy-3-quinolinyl)boronic acid;Boronic acid, B-(2-methoxy-3-quinolinyl)-;(2-methoxy-3-quinolinyl)boronic acid(SALTDATA: FREE);2-Methoxyquinoline-3-boronic acid ISO 9001：2015 REACH
- CBNumber
- CB01262515
- Molecular Formula
- C10H10BNO3
- Formula Weight
- 203
- MOL File
- 886853-93-6.mol
2-Methoxyquinoline-3-boronic acid Property
- Melting point:
- 254 °C
- Boiling point:
- 414.2±55.0 °C(Predicted)
- Density
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 7.10±0.30(Predicted)
- Appearance
- White to off-white Solid
Safety
- Hazard Codes
- Xi
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M342780
- Product name
- 2-Methoxyquinoline-3-boronicAcid
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- M342780
- Product name
- 2-Methoxyquinoline-3-boronicAcid
- Packaging
- 500mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 8H60-1-Z0
- Product name
- 2-Methoxyquinoline-3-boronic acid
- Packaging
- 1g
- Price
- $376
- Updated
- 2021/12/16
- Product number
- BOR0005724
- Product name
- 2-METHOXYQUINOLINE-3-BORONIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $379.05
- Updated
- 2021/12/16
- Product number
- 093067
- Product name
- 2-Methoxyquinoline-3-boronic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $416
- Updated
- 2021/12/16
2-Methoxyquinoline-3-boronic acid Chemical Properties,Usage,Production
Synthesis
6931-16-4
5419-55-6
886853-93-6
To a solution of tetrahydrofuran (THF, 140 mL) containing 2-methoxyquinoline (10.0 g, 62.8 mmol) and triisopropyl borate (17.86 g, 95.1 mmol) was slowly added a solution of LDA (75.4 mmol) prepared from diisopropylamine (Pr'2NH) and n-butyllithium (n-BuLi) at -78 °C. The reaction mixture was stirred continuously at -78 °C for 4 h, followed by slow warming to room temperature and stirring overnight. Upon completion of the reaction, the reaction was quenched with saturated ammonium chloride (NH4Cl, 68 mL) solution and the pH was adjusted with 3 M hydrochloric acid (HCl) to 5. The organic solvents THF and hexane were removed by vacuum evaporation to give a white solid precipitate of 2-methoxyquinoline-3-boronic acid. The mixture was filtered through a Brinell funnel and the solid product was washed thoroughly with deionized water (H2O) and dried under high vacuum to give the target product (12.11 g, 95% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3), 13C NMR (400 MHz, CDCl3) and HRMS (EI).1H NMR data: δ8.64 (1H, s), 7.85 (1H, d, J=8.3 Hz), 7.80 (1H, d, J=7.9 Hz), 7.68 (1H, dd, J= 14.1,1.1Hz), 7.41 (1H, t, J=7.5Hz), 5.91 (2H, s, br), 4.18 (3H, s).13C NMR data: δ164.9,149.8,148.1,131.1,128.6,127.4,125.5,124.7,53.9.HRMS (EI) calculated values C10H10BNO3 ([M]+) 203.0754, measured value 203.0758.
References
[1] Patent: WO2006/47888, 2006, A1. Location in patent: Page/Page column 73; 131-132
[2] Patent: KR2016/18458, 2016, A. Location in patent: Paragraph 0309; 0312; 0313
[3] European Journal of Medicinal Chemistry, 2010, vol. 45, # 4, p. 1657 - 1662
2-Methoxyquinoline-3-boronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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