2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine

Product Name: 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
CAS No.: 1052686-60-8
Chemical Name: 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
Synonyms: 2-Methoxypyrimidine-5-boronic acid pinacol ester;2-Methoxypyrimidin-5-ylboronic acid pinacol ester;2-methoxypyrimidine-5-boronic acid frequency which ol ester;2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine;Pyrimidine, 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine ISO 9001：2015 REACH
CBNumber: CB52515604
Molecular Formula: C11H17BN2O3
Formula Weight: 236.08
MOL File: 1052686-60-8.mol

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2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine Property

Boiling point:: 354.3±34.0 °C(Predicted)
Density: 1.10±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 0.94±0.22(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: M333168
Product name: 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
Packaging: 50mg
Price: $90
Updated: 2021/12/16

TRC

Product number: M333168
Product name: 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
Packaging: 25mg
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: OR361403
Product name: 2-Methoxypyrimidin-5-ylboronic acid, pinacol ester
Packaging: 250mg
Price: $137
Updated: 2021/12/16

AK Scientific

Product number: Z6794
Product name: 2-Methoxypyrimidin-5-ylboronicacidpinacolester
Packaging: 1g
Price: $491
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0006456
Product name: 2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIMIDINE
Purity: 95.00%
Packaging: 5MG
Price: $498.84
Updated: 2021/12/16

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2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine Chemical Properties,Usage,Production

Synthesis

73183-34-3

14001-66-2

1052686-60-8

A solvent mixture (DME/H2O/Toluene/EtOH = 10:1:6:7, 7 mL) of 5-bromo-2-methoxypyrimidine (800 mg, 4.26 mmol) and potassium acetate (1.25 g, 12.77 mmol) was added to the reaction vial. Pd(dppf)Cl2-DCM (700 mg, 0.85 mmol) and bis(pinacolato)diboron (2.44 g, 9.6 mmol) were subsequently added. The reaction mixture was degassed and replaced three times with nitrogen before the reaction was stirred at 85 °C overnight. The reaction progress was monitored by TLC and after confirming the completion of the reaction, the reaction mixture was cooled to room temperature. The mixture was diluted with water (10 mL) and extracted with ethyl acetate (30 mL × 3). The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated. Purification by silica gel column chromatography (eluent ratio PE:EA = 5:1) afforded the target product 2-methoxypyrimidine-5-boronic acid pinacol ester (24-4) as a yellow solid (1.0 g, 98% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 19, p. 5849 - 5853
[2] Patent: US9138427, 2015, B2. Location in patent: Page/Page column 290
[3] Patent: WO2017/197151, 2017, A1. Location in patent: Page/Page column 40

2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine Suppliers

China 72 India 2 United States 4 Global 78

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View Lastest Price from 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine 1052686-60-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-13

Henan Aochuang Chemical Co.,Ltd.

Product: 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine 1052686-60-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

Career Henan Chemical Co

Product: 2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine 1052686-60-8
Price: US $1.00/KG
Min. Order: 1g
Purity: 98%
Supply Ability: 200kgs
Release date: 2020-01-09

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1052686-60-8