4-BROMO-2,3-DIFLUOROANILINE
Application- Product Name
- 4-BROMO-2,3-DIFLUOROANILINE
- CAS No.
- 112279-72-8
- Chemical Name
- 4-BROMO-2,3-DIFLUOROANILINE
- Synonyms
- 4-Bromo-2,3-difluorobenzenamine;4-Bromo-2,3-difluoroaniline 97%;Benzenamine, 4-bromo-2,3-difluoro-;4-BROMO-2,3-DIFLUOROANILINE ISO 9001：2015 REACH
- CBNumber
- CB01264034
- Molecular Formula
- C6H4BrF2N
- Formula Weight
- 208
- MOL File
- 112279-72-8.mol
4-BROMO-2,3-DIFLUOROANILINE Property
- Melting point:
- 58-63°
- Boiling point:
- 215.1±35.0℃ (760 Torr)
- Density
- 1.788±0.06 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 83.9±25.9℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 1.48±0.10(Predicted)
- form
- solid
- color
- Light purple/tan
- InChI
- InChI=1S/C6H4BrF2N/c7-3-1-2-4(10)6(9)5(3)8/h1-2H,10H2
- InChIKey
- UEVLRVBHLWKNEN-UHFFFAOYSA-N
- SMILES
- C1(N)=CC=C(Br)C(F)=C1F
Safety
- HS Code
- 2921420090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- B700628
- Product name
- 4-Bromo-2,3-difluoroaniline
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- PC49248
- Product name
- 4-Bromo-2,3-difluoroaniline
- Purity
- 97%
- Packaging
- 25g
- Price
- $188
- Updated
- 2021/12/16
- Product number
- 3630-B-X5
- Product name
- 4-Bromo-2,3-difluoroaniline
- Packaging
- 25g
- Price
- $223
- Updated
- 2021/12/16
- Product number
- 126219
- Product name
- 4-Bromo-2,3-difluoroaniline
- Purity
- >95%
- Packaging
- 5g
- Price
- $225
- Updated
- 2021/12/16
- Product number
- PC49248
- Product name
- 4-Bromo-2,3-difluoroaniline
- Purity
- 97%
- Packaging
- 1g
- Price
- $22
- Updated
- 2021/12/16
4-BROMO-2,3-DIFLUOROANILINE Chemical Properties,Usage,Production
Application
4-Bromo-2,3-difluoroaniline is an organic synthesis intermediate and a pharmaceutical intermediate that can be used in laboratory research and development processes and chemical production processes.
Synthesis
4519-40-8
112279-72-8
The general procedure for the synthesis of 4-bromo-2,3-difluoroaniline using 2,3-difluoroaniline as starting material was as follows: 2,3-difluoroaniline (1 eq.) and N-bromosuccinimide (1 eq.) were dissolved in acetonitrile (1 M). The reaction mixture was stirred at 35°C for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure to give the crude product. The crude product was dissolved in water and extracted with ethyl acetate. The organic phases were combined and concentrated under reduced pressure to obtain the crude product. Finally, the crude product was purified by silica gel column chromatography to afford the target compound 4-bromo-2,3-difluoroaniline in 68% yield.
References
[1] Patent: US2012/253040, 2012, A1. Location in patent: Page/Page column 35
[2] Patent: US2016/96841, 2016, A1. Location in patent: Paragraph 0380
[3] Patent: WO2012/58671, 2012, A1. Location in patent: Page/Page column 88-89
[4] Patent: WO2007/55514, 2007, A1. Location in patent: Page/Page column 142
[5] Patent: US2010/204477, 2010, A1. Location in patent: Page/Page column 30
4-BROMO-2,3-DIFLUOROANILINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-BROMO-2,3-DIFLUOROANILINE manufacturers
- Product
- 4-BROMO-2,3-DIFLUOROANILINE 112279-72-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11