ChemicalBook > CAS DataBase List > 4-BROMO-2,3-DIFLUOROANILINE

4-BROMO-2,3-DIFLUOROANILINE

Application

Product Name: 4-BROMO-2,3-DIFLUOROANILINE
CAS No.: 112279-72-8
Chemical Name: 4-BROMO-2,3-DIFLUOROANILINE
Synonyms: 4-Bromo-2,3-difluorobenzenamine;4-Bromo-2,3-difluoroaniline 97%;Benzenamine, 4-bromo-2,3-difluoro-;4-BROMO-2,3-DIFLUOROANILINE ISO 9001：2015 REACH
CBNumber: CB01264034
Molecular Formula: C6H4BrF2N
Formula Weight: 208
MOL File: 112279-72-8.mol

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4-BROMO-2,3-DIFLUOROANILINE Property

Melting point:: 58-63°
Boiling point:: 215.1±35.0℃ (760 Torr)
Density: 1.788±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:: 83.9±25.9℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 1.48±0.10(Predicted)
form: solid
color: Light purple/tan
InChI: InChI=1S/C6H4BrF2N/c7-3-1-2-4(10)6(9)5(3)8/h1-2H,10H2
InChIKey: UEVLRVBHLWKNEN-UHFFFAOYSA-N
SMILES: C1(N)=CC=C(Br)C(F)=C1F

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Safety

HS Code: 2921420090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: B700628
Product name: 4-Bromo-2,3-difluoroaniline
Packaging: 500mg
Price: $110
Updated: 2021/12/16

Apolloscientific

Product number: PC49248
Product name: 4-Bromo-2,3-difluoroaniline
Purity: 97%
Packaging: 25g
Price: $188
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3630-B-X5
Product name: 4-Bromo-2,3-difluoroaniline
Packaging: 25g
Price: $223
Updated: 2021/12/16

Matrix Scientific

Product number: 126219
Product name: 4-Bromo-2,3-difluoroaniline
Purity: >95%
Packaging: 5g
Price: $225
Updated: 2021/12/16

Apolloscientific

Product number: PC49248
Product name: 4-Bromo-2,3-difluoroaniline
Purity: 97%
Packaging: 1g
Price: $22
Updated: 2021/12/16

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4-BROMO-2,3-DIFLUOROANILINE Chemical Properties,Usage,Production

Application

4-Bromo-2,3-difluoroaniline is an organic synthesis intermediate and a pharmaceutical intermediate that can be used in laboratory research and development processes and chemical production processes.

Synthesis

4519-40-8

112279-72-8

The general procedure for the synthesis of 4-bromo-2,3-difluoroaniline using 2,3-difluoroaniline as starting material was as follows: 2,3-difluoroaniline (1 eq.) and N-bromosuccinimide (1 eq.) were dissolved in acetonitrile (1 M). The reaction mixture was stirred at 35°C for 2 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure to give the crude product. The crude product was dissolved in water and extracted with ethyl acetate. The organic phases were combined and concentrated under reduced pressure to obtain the crude product. Finally, the crude product was purified by silica gel column chromatography to afford the target compound 4-bromo-2,3-difluoroaniline in 68% yield.

References

[1] Patent: US2012/253040, 2012, A1. Location in patent: Page/Page column 35
[2] Patent: US2016/96841, 2016, A1. Location in patent: Paragraph 0380
[3] Patent: WO2012/58671, 2012, A1. Location in patent: Page/Page column 88-89
[4] Patent: WO2007/55514, 2007, A1. Location in patent: Page/Page column 142
[5] Patent: US2010/204477, 2010, A1. Location in patent: Page/Page column 30

4-BROMO-2,3-DIFLUOROANILINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-BROMO-2,3-DIFLUOROANILINE manufacturers

Career Henan Chemical Co

Product: 4-BROMO-2,3-DIFLUOROANILINE 112279-72-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-11

112279-72-8, 4-BROMO-2,3-DIFLUOROANILINERelated Search:

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4-Bromo-2,3-difluoroaniline 97%

Benzenamine, 4-bromo-2,3-difluoro-

4-BROMO-2,3-DIFLUOROANILINE ISO 9001：2015 REACH

4-Bromo-2,3-difluorobenzenamine

112279-72-8