1H-Indole-3-carboxamide(9CI)
- Product Name
- 1H-Indole-3-carboxamide(9CI)
- CAS No.
- 1670-85-5
- Chemical Name
- 1H-Indole-3-carboxamide(9CI)
- Synonyms
- 1H-Indole-3-carboxamide(9CI);indole-3-yl carboxylic acid amide;2,6-Piperidinedione,3-[(6-chlorophenyl)methyl]-
- CBNumber
- CB01282935
- Molecular Formula
- C9H8N2O
- Formula Weight
- 160.17
- MOL File
- 1670-85-5.mol
1H-Indole-3-carboxamide(9CI) Property
- Melting point:
- 201 °C
- Boiling point:
- 457.6±18.0 °C(Predicted)
- Density
- 1.328±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 15.80±0.30(Predicted)
- Appearance
- Off-white to light brown Solid
Safety
- HS Code
- 2933998090
N-Bromosuccinimide Price
- Product number
- I629028
- Product name
- 1H-Indole-3-carboxylicAcidAmide
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- W3631
- Product name
- 1H-Indole-3-carboxylicacidamide
- Packaging
- 1g
- Price
- $192
- Updated
- 2021/12/16
- Product number
- CHM0077922
- Product name
- 1H-INDOLE-3-CARBOXYLIC ACID AMIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $808.89
- Updated
- 2021/12/16
- Product number
- CHM0077922
- Product name
- 1H-INDOLE-3-CARBOXYLIC ACID AMIDE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1147.43
- Updated
- 2021/12/16
- Product number
- CHM0077922
- Product name
- 1H-INDOLE-3-CARBOXYLIC ACID AMIDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1421.65
- Updated
- 2021/12/16
1H-Indole-3-carboxamide(9CI) Chemical Properties,Usage,Production
Synthesis
5457-28-3
1670-85-5
GENERAL METHOD: To an anhydrous ethanol solution of 3-cyanoindole (15 mmol) was added 40% aqueous NaOH (5 mL) under stirring conditions. The reaction process was monitored by thin layer chromatography (TLC). Subsequently, 30% aqueous H2O2 solution (10.5 mL, 104.7 mmol) was slowly added dropwise to the reaction mixture. Upon completion of the reaction, the precipitated solid was collected by filtration, washed with water and recrystallized with anhydrous ethanol. Finally, the product was dried under vacuum to give 1H-indole-3-carboxamide (20a). The product was a white solid in 75% yield with a melting point of 195-197 °C (literature value 197-199 °C [31]).1H NMR (δ, ppm): 6.84 (s, 1H, NH), 7.13-7.21 (m, 2H, ArH), 7.47 (d, J = 8.0 Hz, 2H, ArH), 8.08 (s, 1H, NH), 8.20 (d, J = 7.5 Hz, 1H, ArH), 11.60 (s, 1H, NH).
References
[1] Applied Organometallic Chemistry, 2014, vol. 28, # 12, p. 900 - 907
[2] Catalysis Science and Technology, 2015, vol. 5, # 3, p. 1606 - 1622
[3] Synthetic Communications, 2013, vol. 43, # 21, p. 2867 - 2875
[4] Dalton Transactions, 2016, vol. 45, # 34, p. 13590 - 13603
[5] Russian Journal of General Chemistry, 2017, vol. 87, # 12, p. 3006 - 3016
1H-Indole-3-carboxamide(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Indole-3-carboxamide(9CI) Suppliers
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