Lurosetron

Product Name
Lurosetron
CAS No.
128486-54-4
Chemical Name
Lurosetron
Synonyms
Lurosetron;Lurosetron [inn:ban];6-fluoro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrido[4,3-b]indol-1-one;1H-Pyrido[4,3-b]indol-1-one, 6-fluoro-2,3,4,5-tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-
CBNumber
CB91402280
Molecular Formula
C17H17FN4O
Formula Weight
312.34
MOL File
128486-54-4.mol
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Lurosetron Property

Boiling point:
650.1±55.0 °C(Predicted)
Density 
1.40±0.1 g/cm3(Predicted)
pka
14.01±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0011827
Product name
LUROSETRON
Purity
95.00%
Packaging
5MG
Price
$503.49
Updated
2021/12/16
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Lurosetron Chemical Properties,Usage,Production

Uses

Lurosetron (GR-87442) is a 6-fluoro analogue of Alosetron (HY-70050A). Lurosetron is a serotonin 5-HT3 receptor antagonist. Lurosetron inhibits recombinant (rbt) CYP1A2, with an IC50 of 0.1 μM. Lurosetron also inhibits other CYP isoforms, including rbtCYP2C9 and rbtCYP3A4 with IC50s ranging between 3.5 μM and 16 μM.[1].

IC 50

5-HT3 Receptor

References

[1] Somers GI, et al. The metabolism of the 5HT3 antagonists ondansetron, alosetron and GR87442 I: a comparison of in vitro and in vivo metabolism and in vitro enzyme kinetics in rat, dog and human hepatocytes, microsomes and recombinant human enzymes. Xenobiotica. 2007 Aug;37(8):832-54. DOI:10.1080/00498250701485575

Lurosetron Preparation Products And Raw materials

Raw materials

Preparation Products

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Lurosetron Suppliers

CHINA 2 Global 2
Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28172
Advantage
58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
29496
Advantage
58

128486-54-4, LurosetronRelated Search:

7-FLUORO-1H-INDOLE-3-CARBALDEHYDE (1-Methyl-1H-indol-3-yl)-methylamine 1H-Indole-3-carboxamide(9CI) 7-Fluoroindole Lurosetron 2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indole 2,3,4,5-Tetrahydro-5-methyl-1H-pyrido[4,3-b]indol-1-one 3-CARBAMOYL-2-METHYLINDOLE N-(2-(1-METHYL-1H-PYRROL-2-YL)ETHYL)FORMAMIDE ALOSETRON 1-METHYL-4,5,6,7-TETRAHYDRO-1H-PYRROLO[3,2-C]PYRIDINE 2-METHYL-3-N,N-DIMETHYLAMINOMETHYLINDOLE 7-FLUORO-1H-INDOL-3-METHYLAMINE

  • Lurosetron
  • Lurosetron [inn:ban]
  • 6-fluoro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrido[4,3-b]indol-1-one
  • 1H-Pyrido[4,3-b]indol-1-one, 6-fluoro-2,3,4,5-tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-
  • 128486-54-4