3-CHLORO-5-HYDROXY-BENZOIC ACID

Product Name: 3-CHLORO-5-HYDROXY-BENZOIC ACID
CAS No.: 53984-36-4
Chemical Name: 3-CHLORO-5-HYDROXY-BENZOIC ACID
Synonyms: 3-chloro-5-hydroxy BA;GPR81 Agonist, 3Cl-5OH-BA;5-Chloro-m-salicylic Acid;3-CHLORO-5-HYDROXY-BENZOIC ACID;5-(hydroxy)-3-chlorobenzoic acid;Benzoic acid, 3-chloro-5-hydroxy-;GPR81 Agonist, 3Cl-5OH-BA - CAS 53984-36-4 - Calbiochem
CBNumber: CB0129376
Molecular Formula: C7H5ClO3
Formula Weight: 172.57
MOL File: 53984-36-4.mol

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3-CHLORO-5-HYDROXY-BENZOIC ACID Property

Melting point:: 244.0 to 248.0 °C
Boiling point:: 364.8±27.0 °C(Predicted)
Density: 1.536±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: soluble15mg/mL (clear solution)
pka: 3.71±0.10(Predicted)
form: powder
color: white to beige
InChIKey: RJOLIYHZZKAIET-UHFFFAOYSA-N
CAS DataBase Reference: 53984-36-4

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Safety

Hazard Codes: Xn
Risk Statements: 22-37/38-41
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0447
Product name: 3-Chloro-5-hydroxybenzoic acid
Purity: ≥97% (HPLC)
Packaging: 25mg
Price: $309
Updated: 2023/01/07

TCI Chemical

Product number: C3183
Product name: 3-Chloro-5-hydroxybenzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $116
Updated: 2024/03/01

TCI Chemical

Product number: C3183
Product name: 3-Chloro-5-hydroxybenzoic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $391
Updated: 2024/03/01

Cayman Chemical

Product number: 16795
Product name: 3-chloro-5-hydroxy BA
Purity: ≥98%
Packaging: 25mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 16795
Product name: 3-chloro-5-hydroxy BA
Purity: ≥98%
Packaging: 50mg
Price: $61
Updated: 2024/03/01

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3-CHLORO-5-HYDROXY-BENZOIC ACID Chemical Properties,Usage,Production

Uses

GPR81, also known as hydroxycarboxylic acid receptor 1 (HCAR1), is a recently de-orphanized receptor that is activated by lactic acid (EC50 ~ 1.5 mM) but not by other hydroxycarboxylic acids. 3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 = 16 μM) that is inactive against the related GPR109a (HCAR2) receptor. It is similarly effective at GPR81 receptors from a variety of mammalian species and is bioavailable, stimulating lipolysis (increased serum free fatty acids) in mice fed high fat chow for 10 weeks. 3-chloro-5-hydroxy BA, like lactate, blocks basal ghrelin secretion by primary gastric mucosal cells.[Cayman Chemical]

Uses

5-Chloro-m-salicylic Acid was studied as a potential selective lactate receptor (GPR81) agonists with antilipolytic effects.

Biological Activity

3-chloro-5-hydroxy ba is a gpr81 agonist.gpr81 (hca1) is a member of g-protein-coupled receptors (gpcrs). gpr81 is predominantly expressed on adipocytes and is activated by the endogenous ligands 2-hydroxypropanoate (lactate). stimulation of gpr81 in adipose tissue lead to a decrease in the lipolysis of triglycerides by hormone-sensitive lipase, which resulted in reduced transport of fatty acids to the liver and a decrease in hepatic triglycerides [1].

in vitro

in the hgpr81 assay, 3-chloro-5-hydroxybenzoic acid showed the potency against gpr81 with an ec50 of 16 μm. the ec50 of 3-chloro-5-hydroxybenzoic acid against monkey gpr81, dog gpr81, rat gpr81, mouse gpr81, and hamster gpr81 was 17 μm, 67 μm, 7 μm, 22 μm and 27 μm, respectively [1]. 3-chloro-5-hydroxy ba blocked basal ghrelin secretion by primary gastric mucosal cells [2].

in vivo

in mice, oral administration of 3-chloro-5-hydroxybenzoic acid at 30 mg/kg provided a cmax of 67 μm at approximately 3-fold over the in vitro ec50 with an aucinf of 54 h μm and a short t1/2 of 1.5 h, and the 100 mg/kg p.o dose attained a cmax of 342 μm at greater than 15-fold over the observed in vitro ec50 [1].

References

[1]. dvorak c a, liu c, shelton j, et al. identification of hydroxybenzoic acids as selective lactate receptor (gpr81) agonists with antilipolytic effects[j]. acs medicinal chemistry letters, 2012, 3(8): 637-639.
[2]. engelstoft m s, park w, sakata i, et al. seven transmembrane g protein-coupled receptor repertoire of gastric ghrelin cells[j]. molecular metabolism, 2013, 2(4): 376-392.

3-CHLORO-5-HYDROXY-BENZOIC ACID Preparation Products And Raw materials

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3-CHLORO-5-HYDROXY-BENZOIC ACID Suppliers

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View Lastest Price from 3-CHLORO-5-HYDROXY-BENZOIC ACID manufacturers

Henan Fengda Chemical Co., Ltd

Product: 3-CHLORO-5-HYDROXY-BENZOIC ACID 53984-36-4
Price: US $3.00-0.20/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-26

Henan Aochuang Chemical Co.,Ltd.

Product: 3-CHLORO-5-HYDROXY-BENZOIC ACID 53984-36-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-22

Career Henan Chemical Co

Product: 3-CHLORO-5-HYDROXY-BENZOIC ACID 53984-36-4
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200kg
Release date: 2018-08-15

53984-36-4, 3-CHLORO-5-HYDROXY-BENZOIC ACIDRelated Search:

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3-CHLORO-5-HYDROXY-BENZOIC ACID

5-(hydroxy)-3-chlorobenzoic acid

5-Chloro-m-salicylic Acid

3-chloro-5-hydroxy BA

Benzoic acid, 3-chloro-5-hydroxy-

GPR81 Agonist, 3Cl-5OH-BA

GPR81 Agonist, 3Cl-5OH-BA - CAS 53984-36-4 - Calbiochem

53984-36-4

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