ChemicalBook > CAS DataBase List > Amtolmetin guacil

Amtolmetin guacil

Product Name
Amtolmetin guacil
CAS No.
87344-06-7
Chemical Name
Amtolmetin guacil
Synonyms
med15;Eufans;ArtroMed;Amtolmetin;AMTOLMETIN GUACIL;AMtolMetin Guacyl;AMTOLMETIO GUACIL;AMtolMethin Guacil;Amtolmetin guacil, 10 mM in DMSO;2-methoxyphenyl1-methyl-5-p-methylbenzoylpyrrole-2-acetoamidoacetate
CBNumber
CB0129750
Molecular Formula
C24H24N2O5
Formula Weight
420.46
MOL File
87344-06-7.mol
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Amtolmetin guacil Property

Melting point:
117-120°
Boiling point:
663.3±55.0 °C(Predicted)
Density 
1.19±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
13.90±0.46(Predicted)
color 
Pale Brown to Light Brown
CAS DataBase Reference
87344-06-7(CAS DataBase Reference)
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Safety

Toxicity
LD50 in male mice, rats (mg/kg): 1370, 1100 i.p.; >1500, 1450 orally (Baglioni)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
A635350
Product name
AmtolmetinGuacil
Packaging
100mg
Price
$125
Updated
2021/12/16
TRC
Product number
A635350
Product name
AmtolmetinGuacil
Packaging
1g
Price
$1010
Updated
2021/12/16
Usbiological
Product number
485633
Product name
MED15
Packaging
100ul
Price
$499
Updated
2021/12/16
Usbiological
Product number
485632
Product name
MED15
Packaging
100ul
Price
$499
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA17894
Product name
Amtolmetin guacil
Packaging
50mg
Price
$120.5
Updated
2021/12/16
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Amtolmetin guacil Chemical Properties,Usage,Production

Description

Amtolmetin guacil is an orally active non-steroidal antiinflammatory drug (NSAID) introduced for the treatment of osteoarthritis, rheumatoid arthritis and post-operative pain. Amtolmetin guacil is reported to elicit a more rapid and improved analgesic action than other agents such as paracetamol. In models of adjuvant arthritis and rheumatic diseases, amtolmetin guacil is more efficacious than existing drugs such as naproxen, indomethacin and piroxicam. As a non-acidic prodrug of tolmetin, it has similar in vivo activity to the parent but with minor ulcerogenic action, lower acute toxicity, and excellent biological and gastric tolerability.

Originator

Sigma Tau (Italy)

Uses

Analgesic; anti-inflammatory used in the treatment of rheumatoid arthritis,

Definition

ChEBI: Amtolmetin guacil is a N-acyl-amino acid.

brand name

Artromed

Clinical Use

Amtolmetin guacil (AMG) is a non-steroidal anti-inflammatory drug developed by Sigma-Tau for the treatment of pain and inflammation. It acts similarly to tolmetin, and in preclinical trials displayed long-lasting anti-inflammatory and analgesic activity. Amtolmetin has a good gastrointestinal tolerability in humans and does not induce gastric ulcers in the rat . The good gastrointestinal tolerability and even a gastroprotective effect was related to an increase of endogenous NO via stimulation of inducible NO synthase in the gastric mucosa .

Synthesis

The condensation of 1-methyl- 5-(4-methylbenzoyl)pyrrole-2-acetic acid with glycine ethyl ester in the presence of carbonyldiimidazole and triethylamine in tetrahydrofuran gives the corresponding ethyl 2-acetate, which is hydrolyzed with NaOH in tetrahydrofuran – water yielding 2- - acetamido]acetic acid. Finally, this compound is esterified with 2-methoxyphenol (guaiacol) in hot tetrahydrofuran with carbonyldiimidazole as catalyst .

Amtolmetin guacil Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Amtolmetin guacil manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Amtolmetin guacil 87344-06-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-10
Career Henan Chemical Co
Product
Amtolmetin guacil 87344-06-7
Price
US $1.00/KG
Min. Order
1KG
Purity
85.0-99.8%
Supply Ability
20 tons
Release date
2019-12-24

87344-06-7, Amtolmetin guacilRelated Search:

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  • 2-(2-Methoxyphenyl)-2-(N-{1-Methyl-5-[(4-Methylphenyl)carbonyl]-1H-pyrrol-2-yl}acetaMido)acetate
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  • 2-Methoxyphenyl 2-(2-(1-Methyl-5-(4-Methylbenzoyl)-1H-pyrrol-2-yl)acetaMido)acetate
  • 2-methoxyphenyl1-methyl-5-p-methylbenzoylpyrrole-2-acetoamidoacetate
  • med15
  • n-((1-methyl-5-(4-methylbenzoyl)-1h-pyrrol-2-yl)acetyl)-glycin2-methoxyphe
  • AMTOLMETIN GUACIL
  • Amtolmetin
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  • 2-Methoxyphenyl 2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetylamino)acetate
  • N-[[5-(4-Methylbenzoyl)-1-methyl-1H-pyrrol-2-yl]acetyl]glycine 2-methoxyphenyl ester
  • Amtolmetin guacilQ: What is Amtolmetin guacil Q: What is the CAS Number of Amtolmetin guacil Q: What is the storage condition of Amtolmetin guacil Q: What are the applications of Amtolmetin guacil
  • Glycine, N-[2-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetyl]-, 2-methoxyphenyl ester
  • Amtolmetin guacil, 10 mM in DMSO
  • 87344-06-7
  • C24H24N2O5
  • Aromatics
  • Heterocycles
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  • Pharmaceuticals