Amtolmetin guacil

ChemicalBook > CAS DataBase List > Amtolmetin guacil

Product Name: Amtolmetin guacil
CAS No.: 87344-06-7
Chemical Name: Amtolmetin guacil
Synonyms: med15;Eufans;ArtroMed;Amtolmetin;AMTOLMETIN GUACIL;AMtolMetin Guacyl;AMTOLMETIO GUACIL;AMtolMethin Guacil;2-methoxyphenyl1-methyl-5-p-methylbenzoylpyrrole-2-acetoamidoacetate;n-((1-methyl-5-(4-methylbenzoyl)-1h-pyrrol-2-yl)acetyl)-glycin2-methoxyphe
CBNumber: CB0129750
Molecular Formula: C24H24N2O5
Formula Weight: 420.46
MOL File: 87344-06-7.mol

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Amtolmetin guacil Property

Melting point:: 117-120°
Boiling point:: 663.3±55.0 °C(Predicted)
Density: 1.19±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 13.90±0.46(Predicted)
color: Pale Brown to Light Brown
CAS DataBase Reference: 87344-06-7(CAS DataBase Reference)

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Safety

Toxicity: LD50 in male mice, rats (mg/kg): 1370, 1100 i.p.; >1500, 1450 orally (Baglioni)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: A635350
Product name: AmtolmetinGuacil
Packaging: 100mg
Price: $125
Updated: 2021/12/16

TRC

Product number: A635350
Product name: AmtolmetinGuacil
Packaging: 1g
Price: $1010
Updated: 2021/12/16

Usbiological

Product number: 485633
Product name: MED15
Packaging: 100ul
Price: $499
Updated: 2021/12/16

Usbiological

Product number: 485632
Product name: MED15
Packaging: 100ul
Price: $499
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17894
Product name: Amtolmetin guacil
Packaging: 50mg
Price: $120.5
Updated: 2021/12/16

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Amtolmetin guacil Chemical Properties,Usage,Production

Description

Amtolmetin guacil is an orally active non-steroidal antiinflammatory drug (NSAID) introduced for the treatment of osteoarthritis, rheumatoid arthritis and post-operative pain. Amtolmetin guacil is reported to elicit a more rapid and improved analgesic action than other agents such as paracetamol. In models of adjuvant arthritis and rheumatic diseases, amtolmetin guacil is more efficacious than existing drugs such as naproxen, indomethacin and piroxicam. As a non-acidic prodrug of tolmetin, it has similar in vivo activity to the parent but with minor ulcerogenic action, lower acute toxicity, and excellent biological and gastric tolerability.

Originator

Sigma Tau (Italy)

Uses

Analgesic; anti-inflammatory used in the treatment of rheumatoid arthritis,

Definition

ChEBI: Amtolmetin guacil is a N-acyl-amino acid.

brand name

Artromed

Clinical Use

Amtolmetin guacil (AMG) is a non-steroidal anti-inflammatory drug developed by Sigma-Tau for the treatment of pain and inflammation. It acts similarly to tolmetin, and in preclinical trials displayed long-lasting anti-inflammatory and analgesic activity. Amtolmetin has a good gastrointestinal tolerability in humans and does not induce gastric ulcers in the rat . The good gastrointestinal tolerability and even a gastroprotective effect was related to an increase of endogenous NO via stimulation of inducible NO synthase in the gastric mucosa .

Synthesis

The condensation of 1-methyl- 5-(4-methylbenzoyl)pyrrole-2-acetic acid with glycine ethyl ester in the presence of carbonyldiimidazole and triethylamine in tetrahydrofuran gives the corresponding ethyl 2-acetate, which is hydrolyzed with NaOH in tetrahydrofuran – water yielding 2- - acetamido]acetic acid. Finally, this compound is esterified with 2-methoxyphenol (guaiacol) in hot tetrahydrofuran with carbonyldiimidazole as catalyst .

Amtolmetin guacil Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Amtolmetin guacil manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Amtolmetin guacil 87344-06-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-10

Career Henan Chemical Co

Product: Amtolmetin guacil 87344-06-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 85.0-99.8%
Supply Ability: 20 tons
Release date: 2019-12-24

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AMTOLMETIN GUACIL

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AMTOLMETIO GUACIL

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Amtolmetin guacilQ: What is Amtolmetin guacil Q: What is the CAS Number of Amtolmetin guacil Q: What is the storage condition of Amtolmetin guacil Q: What are the applications of Amtolmetin guacil

Glycine, N-[2-[1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl]acetyl]-, 2-methoxyphenyl ester

87344-06-7

C24H24N2O5

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