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Fosfomycin tromethamine

Product Name
Fosfomycin tromethamine
CAS No.
78964-85-9
Chemical Name
Fosfomycin tromethamine
Synonyms
z1282;monuril;FOSFOMYCIN TROMETAMOL;FOSFOMYCIN TROMETHAMOL;phosphomycin trometamol;tromethamine-fosfomycin;fosfomycin tromethamine;Fosfomycin Tromethaminel;fosfomycintrometamolsalt;Tromethamine fosfosmycin
CBNumber
CB9365184
Molecular Formula
C7H18NO7P
Formula Weight
259.19
MOL File
78964-85-9.mol
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Fosfomycin tromethamine Property

solubility 
Very soluble in water, slightly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone.
InChIKey
QZJIMDIBFFHQDW-LMLSDSMGSA-N
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Safety

HS Code 
2941906000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
F0400000
Product name
Fosfomycin trometamol
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
f0400000
Price
$190
Updated
2020/08/18
Sigma-Aldrich
Product number
1286322
Product name
Fosfomycin trometamol
Packaging
800mg
Price
$366
Updated
2020/08/18
Cayman Chemical
Product number
23632
Product name
Fosfomycin Trometamol
Purity
≥98%
Packaging
5mg
Price
$29
Updated
2020/06/24
Cayman Chemical
Product number
23632
Product name
Fosfomycin Trometamol
Purity
≥98%
Packaging
10mg
Price
$52
Updated
2020/06/24
Cayman Chemical
Product number
23632
Product name
Fosfomycin Trometamol
Purity
≥98%
Packaging
25mg
Price
$174
Updated
2020/06/24
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Fosfomycin tromethamine Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

Phosphonic acid derivative; antibacterial.

brand name

Monurol (Zambon).

General Description

Fosfomycin tromethamine (Monurol) is a phosphonic acidepoxide derivative that was initially isolated from fermentationsof Streptomyces spp. Making the tromethamine salt greatly expanded the therapeutic utility of this antibacterial because water solubilityincreased enough to allow oral administration.
Fosfomycin is a broad-spectrum, bactericidal antibacterialthat inhibits the growth of E. coli, S. aureus, andSerratia, Klebsiella, Citrobacter, Enterococcus, andEnterobacter spp. at a concentration less than 64 mg/L.Currently fosfomycin is recommended as single-dose therapyfor uncomplicated urinary tract infections. It possessesin vitro efficacy similar to that of norfloxacin and trimethoprim-sulfamethoxazole.
Fosfomycin covalently inactivates the first enzyme in thebacterial cell wall biosynthesis pathway, UDP-N-acetylglucosamineenolpyruvyl transferase (MurA) by alkylation ofthe cysteine-115 residue. The inactivation reaction occursthrough nucleophilic opening of the epoxide ring. Resistanceto fosfomycin can occur through chromosomal mutationsthat result in reduced uptake or reduced MurA affinity for theinhibitor. Plasmid-mediated resistance mechanisms involveconjugative bioinactivation of the antibiotic with glutathione.The frequency of resistant mutants in in vitro studies hasbeen low, and there appears to be little cross-resistance betweenfosfomycin and other antibacterials.

Fosfomycin tromethamine Preparation Products And Raw materials

Raw materials

Preparation Products

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Fosfomycin tromethamine Suppliers

Hubei widely chemical technology Co., Ltd.
Tel
027-83991130
Fax
027-83991130
Email
1718093273@QQ.COM
Country
China
ProdList
2064
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2347
Advantage
56
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070-
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19994
Advantage
64
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9848
Advantage
79
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852-
Fax
QQ:702039778
Email
sales@fortunachem.com
Country
China
ProdList
2986
Advantage
58
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.
Tel
021-34666753;021-33588661
Fax
+86-21-34979012
Email
info@shyrchem.com;info@shyrchem.com
Country
China
ProdList
1403
Advantage
55
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-58378339;025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com;sales@sunlidabio.com
Country
China
ProdList
3815
Advantage
55
Wuhan DKY Technology Co.,Ltd.
Tel
27-81302488- ;27-81302488-
Fax
027-81302088
Email
info@dkybpc.com;2851686510@qq.com
Country
China
ProdList
2011
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-66853366-
Email
sales@chem-strong.com
Country
China
ProdList
15780
Advantage
56
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View Lastest Price from Fosfomycin tromethamine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Fosfomycin Trometamol 78964-85-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-09
career henan chemical co
Product
Fosfomycin tromethamine 78964-85-9
Price
US $7.00/ASSAYS
Min. Order
1KG
Purity
98%
Supply Ability
1000KG
Release date
2018-08-20

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