Fosfomycin tromethamine

Product Name: Fosfomycin tromethamine
CAS No.: 78964-85-9
Chemical Name: Fosfomycin tromethamine
Synonyms: FOSFOMYCIN TROMETAMOL;FOSFOMYCIN TROMETHAMOL;phosphomycin trometamol;tromethamine-fosfomycin;z1282;monuril;Fosfomycin tramine;Fosfomycin tromethanol;Fosfomycine Trometamol;fosfomycin tromethamine
CBNumber: CB9365184
Molecular Formula: C7H18NO7P
Formula Weight: 259.19
MOL File: 78964-85-9.mol

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Fosfomycin tromethamine Property

Melting point:: 122-125oC
storage temp.: Hygroscopic, Refrigerator, under inert atmosphere
solubility: Very soluble in water, slightly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone.
form: Solid
color: White to Off-White
Stability:: Hygroscopic
InChI: InChI=1/C4H11NO3.C3H7O4P/c5-4(1-6,2-7)3-8;1-2-3(7-2)8(4,5)6/h6-8H,1-3,5H2;2-3H,1H3,(H2,4,5,6)/t;2-,3+/s3
InChIKey: QZJIMDIBFFHQDW-LMLSDSMGSA-N
SMILES: C(N)(CO)(CO)CO.P([C@H]1O[C@H]1C)(O)(O)=O |&1:9,11,r|

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Safety

HS Code: 2941906000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P285In case of inadequate ventilation wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: F0400000
Product name: Fosfomycin trometamol
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: f0400000
Price: $153
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1286322
Product name: Fosfomycin trometamol
Packaging: 800mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2512
Product name: Fosfomycin Trometamol
Packaging: 20MG
Price: $125
Updated: 2023/06/20

Cayman Chemical

Product number: 23632
Product name: Fosfomycin Trometamol
Purity: ≥98%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 23632
Product name: Fosfomycin Trometamol
Purity: ≥98%
Packaging: 10mg
Price: $65
Updated: 2024/03/01

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Fosfomycin tromethamine Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

Phosphonic acid derivative; antibacterial.

Uses

Fosfomycin Tromethamine is used as an antibiotic compound in the treatment of urinary tract infections.

Definition

ChEBI: Fosfomycin tromethamine is a phosphonoacetic acid.

brand name

Monurol (Zambon).

General Description

Fosfomycin tromethamine (Monurol) is a phosphonic acidepoxide derivative that was initially isolated from fermentationsof Streptomyces spp. Making the tromethamine salt greatly expanded the therapeutic utility of this antibacterial because water solubilityincreased enough to allow oral administration.
Fosfomycin is a broad-spectrum, bactericidal antibacterialthat inhibits the growth of E. coli, S. aureus, andSerratia, Klebsiella, Citrobacter, Enterococcus, andEnterobacter spp. at a concentration less than 64 mg/L.Currently fosfomycin is recommended as single-dose therapyfor uncomplicated urinary tract infections. It possessesin vitro efficacy similar to that of norfloxacin and trimethoprim-sulfamethoxazole.
Fosfomycin covalently inactivates the first enzyme in thebacterial cell wall biosynthesis pathway, UDP-N-acetylglucosamineenolpyruvyl transferase (MurA) by alkylation ofthe cysteine-115 residue. The inactivation reaction occursthrough nucleophilic opening of the epoxide ring. Resistanceto fosfomycin can occur through chromosomal mutationsthat result in reduced uptake or reduced MurA affinity for theinhibitor. Plasmid-mediated resistance mechanisms involveconjugative bioinactivation of the antibiotic with glutathione.The frequency of resistant mutants in in vitro studies hasbeen low, and there appears to be little cross-resistance betweenfosfomycin and other antibacterials.

Fosfomycin tromethamine Preparation Products And Raw materials

Raw materials

Preparation Products

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Fosfomycin tromethamine Suppliers

China 197 Europe 1 France 1 India 11 Italy 2 Mexico 1 Spain 3 United Kingdom 3 United States 16 Global 235

NANJING DORRA PHARMACEUTICAL TECHNOLOGY CO.,LTD.

Tel: 86-25-82232933 15250951870
Email: sales@dorrapharma.com
Country: China
ProdList: 33
Advantage: 58

Hunan Warner pharmaceutical Co., Ltd. Large

Tel: 0731-83281728
Fax: 0731-83280728
Country: China
ProdList: 15
Advantage: 60

Hubei wei shi reagent group ltd., company

Tel: 027-59102966 18717199209
Email: 2853877583@QQ.com
Country: China
ProdList: 7884
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
Fax: +86 351 7031519
Email: sales@RHFChem.com
Country: China
ProdList: 2338
Advantage: 56

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19179
Advantage: 64

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 9387
Advantage: 52

ZhengZhou HuaWen Chemical Co.Ltd

Tel: 0370-2785118 17550508557
Fax: QQ：3470079902
Email: 675141927@qq.com
Country: China
ProdList: 3203
Advantage: 55

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2866
Advantage: 58

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View Lastest Price from Fosfomycin tromethamine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Fosfomycin tromethamine 78964-85-9
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 98%-102%; EP
Supply Ability: 100KG
Release date: 2021-07-17

airuikechemical co., ltd.

Product: Fosfomycin Tromethamine 78964-85-9
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-08

Hebei Weibang Biotechnology Co., Ltd

Product: Fosfomycin tromethamine 78964-85-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-28

78964-85-9, Fosfomycin tromethamineRelated Search:

CLODRONIC ACID 1,2,4-Butanetriol Zoledronic acid Fosfomycin Tris(hydroxymethyl)aminomethane Lithium diisopropylamide Disodium phosphonomycin Disodium pamidronate 1-Hydroxyethylidene-1,1-diphosphonic acid Glycine Amino tris(methylene phosphonic acid) Meglumine Antipyrine PROPANE-1-PHOSPHONIC ACID TRISTEARIN Amino alcohol 2-[(4-AMINO-PHENYL)-ETHYL-AMINO]-ETHANOL Fosfomycin tromethamine

(3-methyloxiranyl)-phosphonicaci(2r-cis)-phosphonicacicompd.with2-amino-2-(hydroxy

fosfomycincompd.withtrometamol

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Tromethamine fosfosmycin

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FosfoMycin troMethaMine API

Fosfomycin trometamolUSP, 98.0%-102.0%

phosphomycin trometamol

Fosfomycin Tromethaminel

Fosfomycin tromethamine (MK-0955 tromethamine)

monuril

tromethamine-fosfomycin

z1282

FOSFOMYCIN TROMETAMOL

fosfomycin tromethamine

FOSFOMYCIN TROMETHAMOL

(2r-cis)-(3-methyloxiranyl)phosphonic acid compound with 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1)

(1R,2S)-(1,2-Epoxypropyl)phosphonic acid, compound with 2-amino-2-(hyd roxymethyl)-1,3-propanediol (1:1)

Fosfomycin trometamol CRS

Fosfomycin tromethamine USP/EP/BP

Fosfomycin Trometamol Impurity 13

Fosfomycin TrometamolQ: What is Fosfomycin Trometamol Q: What is the CAS Number of Fosfomycin Trometamol Q: What is the storage condition of Fosfomycin Trometamol Q: What are the applications of Fosfomycin Trometamol

Fosfomycin Tromethamine (1286322)

2-Amino-2-(hydroxymethyl)propane-1,3-diol ((2R,3S)-3-methyloxiran-2-yl)phosphonate (Fosfomycin Impurity)

Fosfomycin Tromethamine 2-amino-2-(hydroxymethyl)propane-1,3-diol ((2R,3S)-3- methyloxiran-2-yl) phosphonate

2-amino-2-(hydroxymethyl)propane-1,3-diol ((2R,3S)-3-methyloxiran-2-yl)phosphonate

Fosfomycin tromethanol

Fosfomycine Trometamol

Fosfomycin tramine

78964-85-9

156-2-90

8964-85-9

C4H11NO3C3H7O4P

C7H18NO7P

25919

API

Antibiotics