Fosfomycin tromethamine

Product Name: Fosfomycin tromethamine
CAS No.: 78964-85-9
Chemical Name: Fosfomycin tromethamine
Synonyms: FOSFOMYCIN TROMETAMOL;FOSFOMYCIN TROMETHAMOL;phosphomycin trometamol;tromethamine-fosfomycin;z1282;monuril;Fosfomycin tramine;Fosfomycin tromethanol;Fosfomycine Trometamol;fosfomycin tromethamine
CBNumber: CB9365184
Molecular Formula: C7H18NO7P
Formula Weight: 259.19
MOL File: 78964-85-9.mol

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Fosfomycin tromethamine Property

Melting point:: 122-125oC
storage temp.: Hygroscopic, Refrigerator, under inert atmosphere
solubility: Very soluble in water, slightly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone.
form: Solid
color: White to Off-White
Stability:: Hygroscopic
InChI: InChI=1/C4H11NO3.C3H7O4P/c5-4(1-6,2-7)3-8;1-2-3(7-2)8(4,5)6/h6-8H,1-3,5H2;2-3H,1H3,(H2,4,5,6)/t;2-,3+/s3
InChIKey: QZJIMDIBFFHQDW-LMLSDSMGSA-N
SMILES: C(N)(CO)(CO)CO.P([C@H]1O[C@H]1C)(O)(O)=O |&1:9,11,r|

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Safety

HS Code: 2941906000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P285In case of inadequate ventilation wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: F0400000
Product name: Fosfomycin trometamol
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 1500 mg
Price: $156
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1286322
Product name: Fosfomycin trometamol
Packaging: 800mg
Price: $432
Updated: 2025/07/31

Sigma-Aldrich

Product number: F0400000
Product name: Fosfomycin trometamol
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: f0400000
Price: $153
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2512
Product name: Fosfomycin Trometamol
Packaging: 20MG
Price: $125
Updated: 2023/06/20

Cayman Chemical

Product number: 23632
Product name: Fosfomycin Trometamol
Purity: ≥98%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

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Fosfomycin tromethamine Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

Phosphonic acid derivative; antibacterial.

Uses

Fosfomycin Tromethamine is used as an antibiotic compound in the treatment of urinary tract infections.

Definition

ChEBI: Fosfomycin tromethamine is a phosphonoacetic acid.

brand name

Monurol (Zambon).

General Description

Fosfomycin tromethamine (Monurol) is a phosphonic acidepoxide derivative that was initially isolated from fermentationsof Streptomyces spp. Making the tromethamine salt greatly expanded the therapeutic utility of this antibacterial because water solubilityincreased enough to allow oral administration.
Fosfomycin is a broad-spectrum, bactericidal antibacterialthat inhibits the growth of E. coli, S. aureus, andSerratia, Klebsiella, Citrobacter, Enterococcus, andEnterobacter spp. at a concentration less than 64 mg/L.Currently fosfomycin is recommended as single-dose therapyfor uncomplicated urinary tract infections. It possessesin vitro efficacy similar to that of norfloxacin and trimethoprim-sulfamethoxazole.
Fosfomycin covalently inactivates the first enzyme in thebacterial cell wall biosynthesis pathway, UDP-N-acetylglucosamineenolpyruvyl transferase (MurA) by alkylation ofthe cysteine-115 residue. The inactivation reaction occursthrough nucleophilic opening of the epoxide ring. Resistanceto fosfomycin can occur through chromosomal mutationsthat result in reduced uptake or reduced MurA affinity for theinhibitor. Plasmid-mediated resistance mechanisms involveconjugative bioinactivation of the antibiotic with glutathione.The frequency of resistant mutants in in vitro studies hasbeen low, and there appears to be little cross-resistance betweenfosfomycin and other antibacterials.

Fosfomycin tromethamine Preparation Products And Raw materials

Raw materials

Preparation Products

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Fosfomycin tromethamine Suppliers

China 233 Europe 1 France 1 India 12 Ireland 1 Italy 3 Mexico 1 Spain 3 United Kingdom 3 United States 16 Global 274

NANJING DORRA PHARMACEUTICAL TECHNOLOGY CO.,LTD.

Tel: 025-82232968 15250951870
Email: sales@dorrapharma.com
Country: China
ProdList: 20
Advantage: 58

Hunan Warner pharmaceutical Co., Ltd. Large

Tel: 0731-83281728
Fax: 0731-83280728
Country: China
ProdList: 15
Advantage: 60

Hubei wei shi reagent group ltd., company

Tel: 027-59102966 18717199209
Email: 2853877583@QQ.com
Country: China
ProdList: 7498
Advantage: 58

Henan Kaixin Biomedical Co., Ltd.

Tel: 18135767668 18135767668
Email: 1101014211@qq.com
Country: China
ProdList: 874
Advantage: 58

Wuhan Yuqing Jiaheng Pharmaceutical Co., Ltd

Tel: 027-83850128 18207128853
Email: 3860188266@qq.com
Country: China
ProdList: 992
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
Fax: +86 351 7031519
Email: sales@RHFChem.com
Country: China
ProdList: 2338
Advantage: 56

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

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View Lastest Price from Fosfomycin tromethamine manufacturers

Hangzhou Verychem Science And Technology Co.Ltd

Product: Fosfomycin trometamol 78964-85-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 1 tons
Release date: 2025-11-12

Nanjing Dorra Pharmaceutical Technology Co., Ltd

Product: Fosfomycin tromethamine 78964-85-9
Price: US $0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 100 tons/year
Release date: 2025-11-04

Shaanxi Dideu New Materials Co. Ltd

Product: Fosfomycin tromethamine 78964-85-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-06-03

78964-85-9, Fosfomycin tromethamineRelated Search:

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FosfoMycin troMethaMine API

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phosphomycin trometamol

Fosfomycin Tromethaminel

Fosfomycin tromethamine (MK-0955 tromethamine)

monuril

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z1282

FOSFOMYCIN TROMETAMOL

fosfomycin tromethamine

FOSFOMYCIN TROMETHAMOL

(2r-cis)-(3-methyloxiranyl)phosphonic acid compound with 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1)

(1R,2S)-(1,2-Epoxypropyl)phosphonic acid, compound with 2-amino-2-(hyd roxymethyl)-1,3-propanediol (1:1)

Fosfomycin trometamol CRS

Fosfomycin tromethamine USP/EP/BP

Fosfomycin Trometamol Impurity 13

Fosfomycin TrometamolQ: What is Fosfomycin Trometamol Q: What is the CAS Number of Fosfomycin Trometamol Q: What is the storage condition of Fosfomycin Trometamol Q: What are the applications of Fosfomycin Trometamol

Fosfomycin Tromethamine (1286322)

2-Amino-2-(hydroxymethyl)propane-1,3-diol ((2R,3S)-3-methyloxiran-2-yl)phosphonate (Fosfomycin Impurity)

Fosfomycin Tromethamine 2-amino-2-(hydroxymethyl)propane-1,3-diol ((2R,3S)-3- methyloxiran-2-yl) phosphonate

2-amino-2-(hydroxymethyl)propane-1,3-diol ((2R,3S)-3-methyloxiran-2-yl)phosphonate

Fosfomycin tromethanol

Fosfomycine Trometamol

Fosfomycin tramine

2-Amino-2-(hydroxymethyl)-propan-1,3-diol ((2R,3S)-3-methyloxiran-2-yl)phosphonate

78964-85-9

156-2-90

8964-85-9

C4H11NO3C3H7O4P

C7H18NO7P

25919

API

Antibiotics