Zoledronic acid
- Product Name
- Zoledronic acid
- CAS No.
- 118072-93-8
- Chemical Name
- Zoledronic acid
- Synonyms
- Zoledronic;ZOLEDRONATE;ZoMeta;Reclast;Zoledronic Acid API;Orazol;BPH 91;Aclasta;ZOL 446;CGP-4244
- CBNumber
- CB4395643
- Molecular Formula
- C5H10N2O7P2
- Formula Weight
- 272.09
- MOL File
- 118072-93-8.mol
Zoledronic acid Property
- Melting point:
- 193-2040C (dec)
- Boiling point:
- 764.0±70.0 °C(Predicted)
- Density
- 2.13±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in Water (up to 2 mg/ml).
- form
- solid
- pka
- 1.41±0.10(Predicted)
- color
- White or off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 2 months.
- CAS DataBase Reference
- 118072-93-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 21/22-36/37/38
- Safety Statements
- 24/25-36/37/39
- HS Code
- 2933399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 6111
- Product name
- Zoledronic Acid
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 6111
- Product name
- Zoledronic Acid
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $290
- Updated
- 2021/12/16
- Product number
- Z623505
- Product name
- Zoledronic Acid
- Packaging
- 250mg
- Price
- $1065
- Updated
- 2021/12/16
- Product number
- Z623505
- Product name
- Zoledronic Acid
- Packaging
- 5mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- Z623505
- Product name
- Zoledronic Acid
- Packaging
- 25mg
- Price
- $215
- Updated
- 2021/12/16
Zoledronic acid Chemical Properties,Usage,Production
Description
Zoledronic acid is a white, crystalline powder that is available in vials for reconstitution for IV infusion over at least 15 minutes. It does not undergo metabolic transformation and does not inhibit CYP450 enzymes. Clearance of this agent is dependent on the patient's creatinine clearance, not on dose. Serum creatinine levels should be evaluated before every treatment. Zolendronic acid is contraindicated in patients with severe renal impairment.
Chemical Properties
White Solid
Originator
Zometa,Novartis Pharma,Switz
Uses
Zoledronic acid induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho.
Uses
Bisphosphonate antiresorptive agent
Uses
bone resorption inhibitor
Definition
ChEBI: An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position.
Manufacturing Process
With stirring and under reflux, 8.6 g (0.053 mole) of imidazol-4-yl acetic acid hydrochloride, 7.1 ml of 85% phosphoric acid and 25 ml of chlorobenzene are heated to 100°C. Then 13.9 ml of phosphorus trichloride are added dropwise at 100°C, whereupon evolution of gas occurs. Over the course of 30 min a dense mass precipitates from the reaction mixture. The batch is heated for 3 hours to 100°C and the supernatant chlorobenzene is removed by decantation. With stirring and under reflux, the residual viscous mass is heated to the boil for 3 hours with 40 ml of 9 N hydrochloric acid. The batch is filtered hot with the addition of carbon and the filtrate is diluted with acetone, whereupon the crude 2-(imidazol-4-yl)-1-hydroxy-ethane-1,1- diphosphonic acid precipitates. This product is recrystallised from water. Melting point: 238-240°C (dec.).
brand name
Zometa (Novartis).
Therapeutic Function
Bone calcium regulator
Biological Functions
Zoledronic acid, a bisphosphonate, was approved by the U.S. FDA in 2001 for the treatment of hypercalcemia of malignancy, a metabolic complication that can be life-threatening. Hypercalcemia of malignancy can occur in up to 50% of patients diagnosed with advanced breast cancer, multiple myeloma, and nonsmall cell lung cancer. This condition arises when chemical moieties produced by the tumor cause overstimulation of osteoclasts. When there is an increase in bone degradation, there is a concomitant release of calcium into the plasma. When serum concentrations of calcium rapidly elevate, the kidneys are unable to handle the overload, and hypercalcemia results. This can lead to dehydration, nausea, vomiting, fatigue, and confusion. Zoledronic acid effectively decreases plasma calcium concentrations via inhibition of bone resorption (inhibition of osteoclastic activity and induction of osteoclast apoptosis). It also prevents the increase in osteoclastic activity caused by tumor-based stimulatory factors. Additionally zoledronic acid has been approved by the U.S. FDA for the treatment of multiple myeloma and bone metastases associated with solid tumor–based cancers (e.g., prostrate and lung). This agent is currently in late-stage clinical trials for the treatment and prevention of osteoporosis and, if approved, will be formulated as a 5-mg, once-yearly IV infusion.
Clinical Use
Zoledronic acid is most commonly given to patients whose cancer is no longer responding to hormones, but it also may be given to prevent the bone thinning and weakening that results from hormonal treatments.
Drug interactions
Potentially hazardous interactions with other drugs
Other nephrotoxic drugs: use with caution as can
enhance nephrotoxicity
Metabolism
Zoledronic acid is not metabolised and is excreted unchanged via the kidney. Over the first 24 hours, 39 ± 16
% of the administered dose is recovered in the urine, while the remainder is principally bound to bone tissue.
storage
Store at +4°C
References
1) Green?et al. (1994),?Preclinical pharmacology of CGP 42446, a new, potent, heterocyclic bisphosphonate compound; J. Bone Miner. Res.,?9?745 2) Deeks and Perry (2008)?Zoledronic acid: a review of its use in the treatment of osteoporosis; Drugs Aging,?25?963 3) Perry and Figgitt (2004),?Zoledronic acid: a review of its use in patients with advanced cancer; Drugs,?64?1197 4) Koto?et al. (2010)?Zoledronic acid inhibits proliferation of human fibrosarcoma cells with induction of apoptosis and shows combined effects with other anticancer agents; Oncol. Rep.,?24?233 5) Tonyali?et al. (2010)?The role of zoledronic acid in the adjuvant treatment of breast cancer: current perspectives; Expert Opin. Pharmacother.,?11?2715
Zoledronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Zoledronic acid manufacturers
- Product
- Zoledronic acid 118072-93-8
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- ≥98%
- Supply Ability
- 100kg/month
- Release date
- 2021-06-10
- Product
- Zoledronic acid 118072-93-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-10-25
- Product
- Zoledronic acid 118072-93-8
- Price
- US $20.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 100 tons
- Release date
- 2024-08-09