Zoledronate disodium tetrahydrate

Product Name: Zoledronate disodium tetrahydrate
CAS No.: 165800-07-7
Chemical Name: Zoledronate disodium tetrahydrate
Synonyms: CGP-42446A;Disodium salt tetrahydrate;Zoledronate Disodium, CGP-42446A;ZOLEDRONATE DISODIUM, TETRAHYDRATE;Zoledronic acid disodium tetrahydrate;Zoledronate DisodiuM (C5H8N2Na2O7P24H2O);ZOLEDRONIC ACID, DISODIUM SALT, TETRAHYDRATE;Sodium (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate tetrahydrate;(1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid disodium salt tetrahydrate;Phosphonic acid, P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-, sodium salt, hydrate (1:2:4)
CBNumber: CB2191764
Molecular Formula: C5H13N2NaO8P2
Formula Weight: 314.1
MOL File: 165800-07-7.mol

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Zoledronate disodium tetrahydrate Property

Melting point:: 305-307°C
storage temp.: Sealed in dry,Room Temperature
solubility: Methanol (Slightly, Heated, Sonicated), Water (Slightly, Heated)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: Z623500
Product name: ZoledronicAcidDisodiumSaltTetrahydrate
Packaging: 100mg
Price: $250
Updated: 2021/12/16

Usbiological

Product number: Z0787
Product name: Zoledronic Acid, Disodium Salt, Tetrahydrate
Packaging: 50mg
Price: $283
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0004653
Product name: ZOLEDRONATE DISODIUM TETRAHYDRATE
Purity: 95.00%
Packaging: 50MG
Price: $704.55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FZ28773
Product name: Zoledronic acid, disodium salt, tetrahydrate
Packaging: 25mg
Price: $49.5
Updated: 2021/12/16

AK Scientific

Product number: 8418AA
Product name: Sodium(1-hydroxy-2-(1H-imidazol-1-yl)-1-Phosphonoethyl)phosphonatetetrahydrate
Packaging: 25mg
Price: $116
Updated: 2021/12/16

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Zoledronate disodium tetrahydrate Chemical Properties,Usage,Production

Description

Zoledronate was introduced in Canada as a lyophilized powder in vials for infusion as solution in the treatment of tumor-induced hypercalcemia. This third-generation bisphosphonate can be obtained by reaction of 2-(1-imidazolyl)acetic acid hydrochloride with phosphorous trichloride followed by hydrolysis in concentrated hydrochloric acid, Zoledronate originated from a medicinal chemistry program started at Novartis, Switzerland in 1986 and aimed at discovering a follow-up to pamidronate for the treatment of osteoporosis and metastatic bone disease. It has highly potent inhibitory effect on hypercalcemia induced by vitamin Ds both in vitro in mouse calvarial cultures and in viva in the thyroparathyroidectomized rat. It is respectively 100 and 850-fold more potent than pamidronate in the former and latter tests. Clinically, it was demonstrated that zoledronate achieved normalized serum calcium concentrations in a significantly higher percentage of cancer patients compared to pamidronate. The 5 minute infusion with zoledronate was more convenient than the 2 hour infusion necessary with pamidronate.

Chemical Properties

White Crystalline Powder

Originator

Novartis (Switzerland)

Uses

A biphosphonate bone resorption inhibitor.

brand name

Zometa

Zoledronate disodium tetrahydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Zoledronate disodium tetrahydrate Suppliers

Canada 1 China 21 Europe 3 Germany 1 India 2 South Korea 1 United Kingdom 3 United States 8 Global 40

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165800-07-7, Zoledronate disodium tetrahydrateRelated Search:

Sodium Monofluorophosphate Zofenoprilat Zoledronic acid hydrate [15N2,13C2]-Zoledronic Acid Zoledronic Acid Trihydrate Zoledronic-d3 Acid Ethylenediaminetetraacetic acid disodium salt Imidazole Zoledronic acid Sodium Phosphate, Dibasic Pamidronate disodium salt CHLOROPHOSPHONAZO III 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT 1-Hydroxyethylidene-1,1-diphosphonic acid 1-Hydroxyethanediphosphonic acid sodium salt Etidronic acid monohydrate Zoledronate disodium tetrahydrate Β-GLYCEROPHOSPHATE, DISODIUM SALT

ZOLEDRONATE DISODIUM, TETRAHYDRATE

ZOLEDRONIC ACID, DISODIUM SALT, TETRAHYDRATE

Zoledronate Disodium, CGP-42446A

(1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid disodium salt tetrahydrate

CGP-42446A

Zoledronate DisodiuM (C5H8N2Na2O7P24H2O)

Sodium (1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl)phosphonate tetrahydrate

Disodium salt tetrahydrate

Zoledronic acid disodium tetrahydrate

Phosphonic acid, P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-, sodium salt, hydrate (1:2:4)

165800-07-7

C5H16N2Na2O11P2

C5H8N2Na2O7P24H2O

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Intermediates & Fine Chemicals

Pharmaceuticals