Fosfomycin tromethamine
- Product Name
- Fosfomycin tromethamine
- CAS No.
- 78964-85-9
- Chemical Name
- Fosfomycin tromethamine
- Synonyms
- FOSFOMYCIN TROMETAMOL;FOSFOMYCIN TROMETHAMOL;phosphomycin trometamol;tromethamine-fosfomycin;z1282;monuril;Fosfomycin tromethanol;Fosfomycine Trometamol;fosfomycin tromethamine;Fosfomycin Tromethaminel
- CBNumber
- CB9365184
- Molecular Formula
- C7H18NO7P
- Formula Weight
- 259.19
- MOL File
- 78964-85-9.mol
Fosfomycin tromethamine Property
- Melting point:
- 122-125oC
- storage temp.
- Hygroscopic, Refrigerator, under inert atmosphere
- solubility
- Very soluble in water, slightly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone.
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
- InChI
- InChI=1/C4H11NO3.C3H7O4P/c5-4(1-6,2-7)3-8;1-2-3(7-2)8(4,5)6/h6-8H,1-3,5H2;2-3H,1H3,(H2,4,5,6)/t;2-,3+/s3
- InChIKey
- QZJIMDIBFFHQDW-LMLSDSMGSA-N
- SMILES
- C(N)(CO)(CO)CO.P([C@H]1O[C@H]1C)(O)(O)=O |&1:9,11,r|
Safety
- HS Code
- 2941906000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P285In case of inadequate ventilation wear respiratory protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F0400000
- Product name
- Fosfomycin trometamol
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- f0400000
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 1286322
- Product name
- Fosfomycin trometamol
- Packaging
- 800mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- SML2512
- Product name
- Fosfomycin Trometamol
- Packaging
- 20MG
- Price
- $125
- Updated
- 2023/06/20
- Product number
- 23632
- Product name
- Fosfomycin Trometamol
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 23632
- Product name
- Fosfomycin Trometamol
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $65
- Updated
- 2024/03/01
Fosfomycin tromethamine Chemical Properties,Usage,Production
Chemical Properties
White to off-white powder
Uses
Phosphonic acid derivative; antibacterial.
Uses
Fosfomycin Tromethamine is used as an antibiotic compound in the treatment of urinary tract infections.
Definition
ChEBI: Fosfomycin tromethamine is a phosphonoacetic acid.
brand name
Monurol (Zambon).
General Description
Fosfomycin tromethamine (Monurol) is a phosphonic acidepoxide derivative that was initially isolated from fermentationsof Streptomyces spp. Making the tromethamine salt greatly expanded the therapeutic utility of this antibacterial because water solubilityincreased enough to allow oral administration.
Fosfomycin is a broad-spectrum, bactericidal antibacterialthat inhibits the growth of E. coli, S. aureus, andSerratia, Klebsiella, Citrobacter, Enterococcus, andEnterobacter spp. at a concentration less than 64 mg/L.Currently fosfomycin is recommended as single-dose therapyfor uncomplicated urinary tract infections. It possessesin vitro efficacy similar to that of norfloxacin and trimethoprim-sulfamethoxazole.
Fosfomycin covalently inactivates the first enzyme in thebacterial cell wall biosynthesis pathway, UDP-N-acetylglucosamineenolpyruvyl transferase (MurA) by alkylation ofthe cysteine-115 residue. The inactivation reaction occursthrough nucleophilic opening of the epoxide ring. Resistanceto fosfomycin can occur through chromosomal mutationsthat result in reduced uptake or reduced MurA affinity for theinhibitor. Plasmid-mediated resistance mechanisms involveconjugative bioinactivation of the antibiotic with glutathione.The frequency of resistant mutants in in vitro studies hasbeen low, and there appears to be little cross-resistance betweenfosfomycin and other antibacterials.
Fosfomycin tromethamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Fosfomycin tromethamine manufacturers
- Product
- Fosfomycin tromethamine 78964-85-9
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 98%-102%; EP
- Supply Ability
- 100KG
- Release date
- 2021-07-17
- Product
- Fosfomycin tromethamine 78964-85-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-28
- Product
- Fosfomycin Tromethamine 78964-85-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 3000kg
- Release date
- 2023-08-11