ChemicalBook > CAS DataBase List > GW5074

GW5074

Product Name
GW5074
CAS No.
220904-83-6
Chemical Name
GW5074
Synonyms
W5074;GW5074;CS-399;GW5074, >=98%;GW-5074;GW 5074;GW5074 USP/EP/BP;GW 5074;GW-5074;GW5074;RAF1 KINASE INHIBITOR I;Raf1 Kinase Inhibitor I - CAS 220904-83-6 - Calbiochem;3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one
CBNumber
CB0130215
Molecular Formula
C15H8Br2INO2
Formula Weight
520.94
MOL File
220904-83-6.mol
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GW5074 Property

Boiling point:
561.4±50.0 °C(Predicted)
Density 
2.248±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: soluble
pka
5.86±0.25(Predicted)
form 
solid
color 
yellow to orange-brown
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey
LMXYVLFTZRPNRV-XCVCLJGOSA-N
CAS DataBase Reference
220904-83-6
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Safety

WGK Germany 
3
HS Code 
2933790090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G6416
Product name
GW5074
Purity
powder
Packaging
5mg
Price
$166
Updated
2024/03/01
Sigma-Aldrich
Product number
553008
Product name
Raf1 Kinase Inhibitor I
Packaging
1mg
Price
$187
Updated
2024/03/01
Cayman Chemical
Product number
10010368
Product name
GW 5074
Purity
≥98% (mixture of cis and trans)
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
10010368
Product name
GW 5074
Purity
≥98% (mixture of cis and trans)
Packaging
5mg
Price
$116
Updated
2024/03/01
Sigma-Aldrich
Product number
G6416
Product name
GW5074
Purity
powder
Packaging
25mg
Price
$649
Updated
2024/03/01
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GW5074 Chemical Properties,Usage,Production

Description

GW-5074 (220904-83-6) is a potent inhibitor of cRAF1 kinase (IC50 = 9 nM). Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. GW-5074 displays neuroprotective effects in vivo via a mechanism that is independent of MEK, ERK, and Akt signaling. Cell permeable.

Uses

GW5074 has been used as a specific inhibitor of cRaf1 in C2 murine skeletal myoblasts, HT-29 colorectal adenocarcinoma cell line and neutrophils.

Biological Activity

Potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC 50 = 9 nM). Displays ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm.

Biochem/physiol Actions

GW5074 is a cRaf1 kinase inhibitor, which is placed immediately downstream of Ras in the Motogen activated protein kinase (MAPK) signaling pathway. It elicits protection in GW5074 prevents degeneration in Huntington′s disease and also have therapeutic potential in treating neurodegenerative disorders. GW5074 in combination with anti-inflammatory drug, dexamethasone, attenuates sidestream smoke-induced airway inflammation.

storage

Desiccate at -20°C

References

1) Chang et al. (2005), Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK pathways; Cell Signal., 217 299 2) Huang et al. (2006), Fibroblast growth factor-2 suppresses oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and phosphatidylinositol 3-kinase-independent pathway; J. Pharmacol. Sci., 102 305 3) Lackey et al. (2000), The discovery of potent cRaf1 kinase inhibitors; Bioorg. Med. Chem. Lett., 10 223 4) Chen et al. (2004), Bradykinin B2 receptor mediates NF-kappaB activation and cyclooxygenase-2 expression via the Ras/Raf-1/ERK pathway in human airway epithelial cells; J. Immunol., 173 5219

GW5074 Preparation Products And Raw materials

Raw materials

Preparation Products

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GW5074 Suppliers

China 121 Germany 1 India 1 Japan 1 Switzerland 2 United Kingdom 2 United States 22 Global 150
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View Lastest Price from GW5074 manufacturers

Career Henan Chemical Co
Product
(3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one 220904-83-6
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-23
Career Henan Chemical Co
Product
(3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one 220904-83-6
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-20

220904-83-6, GW5074Related Search:

GW284543 GW788388 GW9662 GW441756 Everolimus Sorafenib Alisertib (MLN8237) Dasatinib SCH772984 Tofacitinib GW 284543 hydrochloride - UNC 10225170 hydrochloride 5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine GW9508 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- GW5074 6-IODO-2,3-DIHYDRO-1H-INDOLE 2H-INDOL-2-ONE, 1,3-DIHYDRO-5-IODO- 2-ETHYL-4-IODO-PHENYLAMINE

  • RAF1 KINASE INHIBITOR I
  • (3Z)-3-[(3,5-DIBROMO-4-HYDROXYPHENYL)METHYLIDENE]-5-IODO-1H-INDOL-2-ONE
  • 5-IODO-3-[(3,5-DIBROMO-4-HYDROXYPHENYL)METHYLENE]-2-INDOLINONE
  • 3-(3,5-DIBROMO-4-HYDROXY-BENZYLIDENE)-5-IODO-1,3-DIHYDRO-INDOL-2-ONE
  • 3-(3,5-DIBROMO-4-HYDROXYBENZYLIDINE)-5-IODO-1,3-DIHYDRO-INDOL-2-ONE
  • GW5074
  • 2H-Indol-2-one, 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-
  • 3-(3,5-dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one
  • GW5074, >=98%
  • (Z)-3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one
  • GW-5074;GW 5074
  • Raf1 Kinase Inhibitor I - CAS 220904-83-6 - Calbiochem
  • GW 5074;GW-5074;GW5074
  • CS-399
  • W5074
  • GW5074 USP/EP/BP
  • 3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodo-2,3-dihydro-1H-indol-2-one
  • 3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one
  • (3E)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one
  • 220904-83-6
  • 20904-83-6
  • C15H8Br2INO2
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Kinase/Phosphatase Biology
  • Raf
  • Serine/Threonine Kinase Inhibitors
  • MAPK
  • Inhibitors