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GW9508

Product Name
GW9508
CAS No.
885101-89-3
Chemical Name
GW9508
Synonyms
GW9508;CS-618;GPR40 Agonist;GW9508, >=99%;GW9508 USP/EP/BP;885101-89-3(GW9508);GW-9508;GW9508;GW 9508;GPR40 Agonist GW9508 GW-9508;4-(3-Phenoxybenzylamino)phenylpropionic acid;GPR40 Agonist - CAS 885101-89-3 - Calbiochem
CBNumber
CB71074937
Molecular Formula
C22H21NO3
Formula Weight
347.41
MOL File
885101-89-3.mol
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GW9508 Property

Melting point:
90-92°C
Boiling point:
538.4±45.0 °C(Predicted)
Density 
1.222±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: >20mg/mL
form 
white powder
pka
4.77±0.10(Predicted)
color 
Off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-37/38-41-50/53
Safety Statements 
26-39-60-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G9797
Product name
GW9508
Purity
≥98% (HPLC)
Packaging
5mg
Price
$161
Updated
2024/03/01
Sigma-Aldrich
Product number
371706
Product name
GPR40 Agonist
Packaging
10mg
Price
$236
Updated
2024/03/01
Cayman Chemical
Product number
10008907
Product name
GW 9508
Purity
≥98%
Packaging
5mg
Price
$38
Updated
2024/03/01
Cayman Chemical
Product number
10008907
Product name
GW 9508
Purity
≥98%
Packaging
10mg
Price
$71
Updated
2024/03/01
Sigma-Aldrich
Product number
G9797
Product name
GW9508
Purity
≥98% (HPLC)
Packaging
25mg
Price
$628
Updated
2024/03/01
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GW9508 Chemical Properties,Usage,Production

Description

GW9508 (885101-89-3) is a selective agonist at the free fatty acid receptor, FFA1/4, (GPR40 and GPR120).1 Displays anti-allodynic and anti-hyperalgesic effects in mouse inflammatory and neuropathic pain models.2 Inhibits LPA-induced proliferation of DU145 and PC-3 cells.3 Decreases hepatic lipid accumulation in a high fat diet steatosis mouse model.4 Promotes brown adipose tissue thermogenesis.5

Uses

GW9508 is a GPR40 full agonist, used to regulate glucose in rats. Can be applied to the treatment of diabetes type 2. GPR120 selective and potent agonist also used in the treatment of diabetes type 2 due to GPR120’s ability to mediate GLP-1 secretion, insulin sensitization and anti-obesity effects.

Uses

GW9508, a selective FFA1/GPR40 agonist, may be used to differentiate and characterize the free fatty acid receptor FFA1/GPR40. GW9508 is used to study the role of FFA1/GPR40 receptors in processes such as the free fatty acid enhancement of glucose-stimulated insulin release and type 2 diabetes. GW9508 is used to study the process by which FFA1/GPR40 receptors protect from ovariectomy-induced bone loss in vivo though inhibition of osteoclast differentiation and suppress complete Freund′s adjuvant (CFA)-Induced inflammatory chronic pain.

Definition

ChEBI: 3-[4-[(3-phenoxyphenyl)methylamino]phenyl]propanoic acid is an aromatic amine.

Biological Activity

Potent and selective agonist for the free fatty acid receptor FFA 1 (GPR40) (pEC 50 values are 7.32, < 4.3 and < 4.3 for FFA 1 , FFA 2 and FFA 3 receptors respectively). Inactive against a range of other GPCRs, kinases, proteases, integrins and PPARs. Potentiates glucose-stimulated insulin secretion in MIN6 cells (pEC 50 = 6.14).

Biochem/physiol Actions

GW9508 is a selective FFA1/GPR40 agonist. GPR40 was formerly an orphan G protein-coupled receptor whose endogenous ligands have now been identified as free fatty acids (FFAs). The receptor, named FFA receptor 1, has been implicated in the pathophysiology of type 2 diabetes and is a drug target because of its role in FFA-mediated enhancement of glucose-stimulated insulin release. GW9508 showed greater than 500-fold selectivity for GPR40 over GPR41 and GPR43 and possessed a good in vitro and in vivo profile with excellent bioavailability. GW9508 stimulated intracellular Ca2+ mobilization in human embryonic kidney HEK-293 cells expressing GPR40 or GPR120, but not in the parent HEK-293 cell line. GW9508 dose dependently potentiated glucose-stimulated insulin secretion in MIN6 cells, but not in primary rat or mouse islets. GW9508 potentiates the KCl-mediated increase in insulin secretion in MIN6 cells.

storage

Store at RT

References

1) Briscoe et al. (2006) Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist molecules, Br. J. Pharmacol. 148 619 2) Karki et al. (2015), Attenuation of inflammatory and neuropathic pain behaviors in mice through activation of free fatty acid receptor GPR40; Mol. Pain, 11 6 3) Liu et al. (2015), Omega-3 fatty acids and other FFA4 agonists inhibit growth factor signaling in human prostate cancer cells; J. Pharmacol. Exp. Ther., 352 380 4) Ou et al. (2014), Activation of free fatty acid receptor 1 improves hepatic steatosis through a p38-dependent pathway; J. Mol. Endocrinol., 53 165 5) Kim et al. (2016), Eicosapentaenoic Acid Potentiates Brown Thermogenesis through FFAR4-dependent Up-regulation of miR-30b and miR-378; J. Biol. Chem., 291 2055

GW9508 Preparation Products And Raw materials

Raw materials

Preparation Products

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GW9508 Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
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View Lastest Price from GW9508 manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
GW9508 885101-89-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Career Henan Chemical Co
Product
885101-89-3(GW9508) 885101-89-3
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2019-12-25

885101-89-3, GW9508Related Search:


  • GW9508
  • 4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoicacid
  • 3-(4-((3-Phenoxybenzyl)aMino)phenyl)propanoic acid
  • 885101-89-3(GW9508)
  • GW9508, >=99%
  • Benzenepropanoic acid, 4-[[(3-phenoxyphenyl)methyl]amino]-
  • 4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid GW9508
  • GW 9508 4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid
  • 4-(3-Phenoxybenzylamino)phenylpropionic acid
  • GPR40 Agonist
  • 3-[4-[(3-phenoxyphenyl)methylamino]phenyl]propanoic acid
  • GPR40 Agonist - CAS 885101-89-3 - Calbiochem
  • GW-9508;GW9508;GW 9508
  • CS-618
  • GW9508 USP/EP/BP
  • GPR40 Agonist GW9508 GW-9508
  • 885101-89-3
  • Inhibitors