GW9508

ChemicalBook > CAS DataBase List > GW9508

Product Name: GW9508
CAS No.: 885101-89-3
Chemical Name: GW9508
Synonyms: GW9508;CS-618;GPR40 Agonist;GW9508, >=99%;GW9508 USP/EP/BP;885101-89-3(GW9508);GW-9508;GW9508;GW 9508;GPR40 Agonist GW9508 GW-9508;4-(3-Phenoxybenzylamino)phenylpropionic acid;GPR40 Agonist - CAS 885101-89-3 - Calbiochem
CBNumber: CB71074937
Molecular Formula: C22H21NO3
Formula Weight: 347.41
MOL File: 885101-89-3.mol

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GW9508 Property

Melting point:: 90-92°C
Boiling point:: 538.4±45.0 °C(Predicted)
Density: 1.222±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: >20mg/mL
form: white powder
pka: 4.77±0.10(Predicted)
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-37/38-41-50/53
Safety Statements: 26-39-60-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G9797
Product name: GW9508
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Sigma-Aldrich

Product number: 371706
Product name: GPR40 Agonist
Packaging: 10mg
Price: $236
Updated: 2024/03/01

Cayman Chemical

Product number: 10008907
Product name: GW 9508
Purity: ≥98%
Packaging: 5mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 10008907
Product name: GW 9508
Purity: ≥98%
Packaging: 10mg
Price: $71
Updated: 2024/03/01

Sigma-Aldrich

Product number: G9797
Product name: GW9508
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $628
Updated: 2024/03/01

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GW9508 Chemical Properties,Usage,Production

Description

GW9508 (885101-89-3) is a selective agonist at the free fatty acid receptor, FFA1/4, (GPR40 and GPR120).1 Displays anti-allodynic and anti-hyperalgesic effects in mouse inflammatory and neuropathic pain models.2 Inhibits LPA-induced proliferation of DU145 and PC-3 cells.3 Decreases hepatic lipid accumulation in a high fat diet steatosis mouse model.4 Promotes brown adipose tissue thermogenesis.5

Uses

GW9508 is a GPR40 full agonist, used to regulate glucose in rats. Can be applied to the treatment of diabetes type 2. GPR120 selective and potent agonist also used in the treatment of diabetes type 2 due to GPR120’s ability to mediate GLP-1 secretion, insulin sensitization and anti-obesity effects.

Uses

GW9508, a selective FFA1/GPR40 agonist, may be used to differentiate and characterize the free fatty acid receptor FFA1/GPR40. GW9508 is used to study the role of FFA1/GPR40 receptors in processes such as the free fatty acid enhancement of glucose-stimulated insulin release and type 2 diabetes. GW9508 is used to study the process by which FFA1/GPR40 receptors protect from ovariectomy-induced bone loss in vivo though inhibition of osteoclast differentiation and suppress complete Freund′s adjuvant (CFA)-Induced inflammatory chronic pain.

Definition

ChEBI: 3-[4-[(3-phenoxyphenyl)methylamino]phenyl]propanoic acid is an aromatic amine.

Biological Activity

Potent and selective agonist for the free fatty acid receptor FFA 1 (GPR40) (pEC 50 values are 7.32, < 4.3 and < 4.3 for FFA 1 , FFA 2 and FFA 3 receptors respectively). Inactive against a range of other GPCRs, kinases, proteases, integrins and PPARs. Potentiates glucose-stimulated insulin secretion in MIN6 cells (pEC 50 = 6.14).

Biochem/physiol Actions

GW9508 is a selective FFA1/GPR40 agonist. GPR40 was formerly an orphan G protein-coupled receptor whose endogenous ligands have now been identified as free fatty acids (FFAs). The receptor, named FFA receptor 1, has been implicated in the pathophysiology of type 2 diabetes and is a drug target because of its role in FFA-mediated enhancement of glucose-stimulated insulin release. GW9508 showed greater than 500-fold selectivity for GPR40 over GPR41 and GPR43 and possessed a good in vitro and in vivo profile with excellent bioavailability. GW9508 stimulated intracellular Ca2+ mobilization in human embryonic kidney HEK-293 cells expressing GPR40 or GPR120, but not in the parent HEK-293 cell line. GW9508 dose dependently potentiated glucose-stimulated insulin secretion in MIN6 cells, but not in primary rat or mouse islets. GW9508 potentiates the KCl-mediated increase in insulin secretion in MIN6 cells.

storage

Store at RT

References

1) Briscoe et al. (2006) Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist molecules, Br. J. Pharmacol. 148 619 2) Karki et al. (2015), Attenuation of inflammatory and neuropathic pain behaviors in mice through activation of free fatty acid receptor GPR40; Mol. Pain, 11 6 3) Liu et al. (2015), Omega-3 fatty acids and other FFA4 agonists inhibit growth factor signaling in human prostate cancer cells; J. Pharmacol. Exp. Ther., 352 380 4) Ou et al. (2014), Activation of free fatty acid receptor 1 improves hepatic steatosis through a p38-dependent pathway; J. Mol. Endocrinol., 53 165 5) Kim et al. (2016), Eicosapentaenoic Acid Potentiates Brown Thermogenesis through FFAR4-dependent Up-regulation of miR-30b and miR-378; J. Biol. Chem., 291 2055

GW9508 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from GW9508 manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: GW9508 885101-89-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Career Henan Chemical Co

Product: 885101-89-3(GW9508) 885101-89-3
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2019-12-25

885101-89-3, GW9508Related Search:

GW284543 GW788388 GW9662 GW441756 GW5074 Y27632 (hydrochloride) Axitinib MK-2206 2HCl ARRY-380 Infigratinib TAK875 (3N-[(2S,3S)-2-AMINO-3-METHYL-PENTANOYL]-1,3-THIAZOLIDINE) HEMIFUMARATE GF109203X BI 6015 GW 284543 hydrochloride - UNC 10225170 hydrochloride 5-[3-Methoxy-4-(4-methoxy-benzyloxy)-benzyl]-pyrimidine-2,4-diamine 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- GW9508

GW9508

4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoicacid

3-(4-((3-Phenoxybenzyl)aMino)phenyl)propanoic acid

885101-89-3(GW9508)

GW9508, >=99%

Benzenepropanoic acid, 4-[[(3-phenoxyphenyl)methyl]amino]-

4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid GW9508

GW 9508 4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid

4-(3-Phenoxybenzylamino)phenylpropionic acid

GPR40 Agonist

3-[4-[(3-phenoxyphenyl)methylamino]phenyl]propanoic acid

GPR40 Agonist - CAS 885101-89-3 - Calbiochem

GW-9508;GW9508;GW 9508

CS-618

GW9508 USP/EP/BP

GPR40 Agonist GW9508 GW-9508

885101-89-3

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