BI 6015

Product Name: BI 6015
CAS No.: 93987-29-2
Chemical Name: BI 6015
Synonyms: B16015;BI 6015;BI6015 ，E0401;BI-6015, 10 mM in DMSO;HNF4 Antagonist, BI6015;2-methyl-1-(2-methyl-5-nitrophenyl)sulfonylbenzimidazole;2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole;2-Methyl-1-(2-methyl-5-nitrophenylsulfonyl)-1H-benzo[d]imidazole;1H-Benzimidazole, 2-methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-;inhibit,promoter,HNF4α,factor,hepatocyte,Inhibitor,diabetes,insulin,BI-6015,BI6015,nuclear,cancer,BI 6015
CBNumber: CB72695661
Molecular Formula: C15H13N3O4S
Formula Weight: 331.35
MOL File: 93987-29-2.mol

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BI 6015 Property

Boiling point:: 570.6±60.0 °C(Predicted)
Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: +2C to +8C
solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 10 mg/ml).
form: Beige powder
pka: 0.88±0.10(Predicted)
color: Tan
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChI: InChI=1S/C15H13N3O4S/c1-10-7-8-12(18(19)20)9-15(10)23(21,22)17-11(2)16-13-5-3-4-6-14(13)17/h3-9H,1-2H3
InChIKey: ILVCPQPMRPHZSG-UHFFFAOYSA-N
SMILES: C1(C)N(S(C2=CC([N+]([O-])=O)=CC=C2C)(=O)=O)C2=CC=CC=C2N=1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 375240
Product name: HNF4 Antagonist, BI6015 - CAS 93987-29-2 - Calbiochem<br />The HNF4 Antagonist, BI6, also referenced under CAS 93987-29-2, controls the biological activity of HNF4.
Packaging: 25mg
Price: $226
Updated: 2025/07/31

Cayman Chemical

Product number: 12032
Product name: BI6015
Purity: ≥95%
Packaging: 5mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 12032
Product name: BI6015
Purity: ≥95%
Packaging: 10mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 12032
Product name: BI6015
Purity: ≥95%
Packaging: 50mg
Price: $360
Updated: 2024/03/01

Tocris

Product number: 4641
Product name: BI6015
Purity: ≥98%(HPLC)
Packaging: 50
Price: $828
Updated: 2021/12/16

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BI 6015 Chemical Properties,Usage,Production

Description

BI-6015 (93987-29-2) is a hepatocyte nuclear factor 4α (HNF4α) antagonist. HNF4α is a central regulator of gene expression in cell types that play a central role in metabolic homeostasis.1 BI-6015 binds to HNF4α with high affinity and modulates the expression of known target genes. It was shown to be selectively cytotoxic to cancer cell lines in vitro and in vivo however in vivo potency was limited by suboptimal pharmacokinetics.2 BI-6015 represents the first small molecule tool for pharmacologic modulation of HNF4α activity.2 Cell permeable.

Uses

BI 6015 is a known HNF4α antagonist that represses the expression of known HNF4α target genes. Studies have shown that BI6015 are also capable of exhibiting selective cytotoxic activities against numerous tumor cell lines.

in vivo

BI-6015 (10-30 mg/kg; i.p. once daily for 5 days) induces loss of HNF4α expression and hepatic steatosis in mice^[1].
BI-6015 (10-30 mg/kg; i.p. daily or every other day for 20-57 days) induces apoptosis in a human hepatocellular carcinoma mouse model^[1].

storage

Store at -20°C

References

[1] H WANG. Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion.[J]. The Journal of Biological Chemistry, 2000, 275 46: 35953-35959. DOI:10.1074/jbc.m006612200
[2] ALICE KISELYUK. HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter.[J]. Chemistry & biology, 2012: 806-818. DOI:10.1016/j.chembiol.2012.05.014

BI 6015 Preparation Products And Raw materials

Raw materials

Preparation Products

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BI 6015 Suppliers

Canada 1 China 60 India 1 United Kingdom 1 United States 9 Global 72

Suzhou Zhixin Biotechnology Co., Ltd.

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93987-29-2, BI 6015Related Search:

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BI 6015

2-Methyl-1-(2-methyl-5-nitrophenylsulfonyl)-1H-benzo[d]imidazole

2-Methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-1H-benzimidazole

inhibit,promoter,HNF4α,factor,hepatocyte,Inhibitor,diabetes,insulin,BI-6015,BI6015,nuclear,cancer,BI 6015

1H-Benzimidazole, 2-methyl-1-[(2-methyl-5-nitrophenyl)sulfonyl]-

B16015

BI-6015, 10 mM in DMSO

HNF4 Antagonist, BI6015

2-methyl-1-(2-methyl-5-nitrophenyl)sulfonylbenzimidazole

BI6015 ，E0401

93987-29-2

Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds