TYRPHOSTIN AG 1296
- Product Name
- TYRPHOSTIN AG 1296
- CAS No.
- 146535-11-7
- Chemical Name
- TYRPHOSTIN AG 1296
- Synonyms
- 1296;AG 1296;A 1296;AG-1296;AG 1296;;TYRPHOSTIN AG 1296;Tyrphostin AG 1296 ，S8024;TYRPHOSTIN AG 1296 USP/EP/BP;Tyrphostin AG 1296 (AG 1296);AG-1296 (Tyrphostin AG 1296);Tyrphostin AG1296, 10 mM in DMSO
- CBNumber
- CB7435034
- Molecular Formula
- C16H14N2O2
- Formula Weight
- 266.29
- MOL File
- 146535-11-7.mol
TYRPHOSTIN AG 1296 Property
- Boiling point:
- 420.2±40.0 °C(Predicted)
- Density
- 1.192±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- solubility
- Soluble in DMSO.
- form
- White solid
- pka
- 0.48±0.30(Predicted)
- color
- Yellow
- Sensitive
- Light Sensitive
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D4601
- Product name
- AG-1296
- Purity
- min. 98.0 %
- Packaging
- 5MG
- Price
- $102
- Updated
- 2025/07/31
- Product number
- D4601
- Product name
- AG-1296
- Purity
- min. 98.0 %
- Packaging
- 25MG
- Price
- $303
- Updated
- 2025/07/31
- Product number
- 10010592
- Product name
- AG 1296
- Purity
- >98%
- Packaging
- 1mg
- Price
- $28
- Updated
- 2024/03/01
- Product number
- 10010592
- Product name
- AG 1296
- Purity
- >98%
- Packaging
- 5mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 10010592
- Product name
- AG 1296
- Purity
- >98%
- Packaging
- 10mg
- Price
- $207
- Updated
- 2024/03/01
TYRPHOSTIN AG 1296 Chemical Properties,Usage,Production
Description
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-
Uses
Tyrphostin AG 1296, is the platelet-derived growth factor receptor (PDGFR) inhibitor, which can causes growth inhibition in glioblastoma cells.
Definition
ChEBI: 6,7-dimethoxy-2-phenylquinoxaline is a quinoxaline derivative.
Synthesis
582-24-1
27841-33-4
146535-11-7
GENERAL METHODS: Triphenyltin (35.5 mg, 0.1 mmol, 10 mol%) and 4,5-dimethoxy-1,2-phenylenediamine (1.2 mmol) were sequentially added to a solution of 2-hydroxyacetophenone (1 mmol) in toluene (6 mL) under air atmosphere. The reaction mixture was stirred at room temperature and the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the solvent was removed by concentration under reduced pressure and the resulting residue was purified by silica gel column chromatography with dichloromethane (CH2Cl2) as eluent. The structure of the final product, 6,7-dimethoxy-2-phenylquinoxaline, was analyzed by melting point determination, nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) and confirmed by comparison with literature data.
in vivo
Tyrphostin AG1296 (40 and 80 mg/kg; i.p. daily for two weeks) suppresses A375R tumor growth in vivo[4].
?
Tyrphostin AG1296 (2 mg/kg; i.p. every other day for 3 weeks) inhibits the atherosclerotic plaque progression and enhances plaque stability by inhibiting inflammatory responses, reducing the expression of matrix metalloproteinases and promoting macrophages from proinflammatory phenotype to anti-inflammatory phenotype[5].
| Animal Model: | Nud/nud mice are injected with A375R cells[4] |
| Dosage: | 40, 80 mg/kg |
| Administration: | I.p. daily for two weeks |
| Result: | Led to an intermediate level of tumor growth suppression at dose of 40 mg/kg, and significant inhibition of A375R tumor growth at dose of 80 mg/kg. Well tolerated by healthy mice without significant signs of overt toxicity or weight loss. |
target
PDGFR
IC 50
PDGFRα; PDGFRβ
References
[1] MARINA KOVALENKO. Phosphorylation Site-Specific Inhibition of Platelet-Derived Growth Factor β-Receptor Autophosphorylation by the Receptor Blocking Tyrphostin AG1296[J]. Biochemistry Biochemistry, 1997, 36 21: 6260-6269. DOI:10.1021/bi962553l
[2] G W KRYSTAL J L P Carlson. Induction of apoptosis and inhibition of small cell lung cancer growth by the quinoxaline tyrphostins.[J]. Cancer research, 1997, 57 11: 2203-2208.
[3] F. STRUTZ. TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2).[J]. Kidney international, 2001, 69 1: 579-592. DOI:10.1046/j.1523-1755.2001.059002579.x
TYRPHOSTIN AG 1296 Preparation Products And Raw materials
Raw materials
Preparation Products
TYRPHOSTIN AG 1296 Suppliers
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View Lastest Price from TYRPHOSTIN AG 1296 manufacturers
- Product
- TYRPHOSTIN AG 1296 146535-11-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-25