ChemicalBook > CAS DataBase List > TYRPHOSTIN AG 1296

TYRPHOSTIN AG 1296

Product Name
TYRPHOSTIN AG 1296
CAS No.
146535-11-7
Chemical Name
TYRPHOSTIN AG 1296
Synonyms
1296;AG 1296;AG-1296;AG 1296;;TYRPHOSTIN AG 1296;TYRPHOSTIN AG 1296 USP/EP/BP;Tyrphostin AG 1296 (AG 1296);AG-1296 (Tyrphostin AG 1296);6,7-DIMETHOXY-3-PHENYLQUINOXALINE;6,7-DIMETHOXY-2-PHENYLQUINOXALINE;Quinoxaline,6,7-dimethoxy-2-phenyl-
CBNumber
CB7435034
Molecular Formula
C16H14N2O2
Formula Weight
266.29
MOL File
146535-11-7.mol
More
Less

TYRPHOSTIN AG 1296 Property

Boiling point:
420.2±40.0 °C(Predicted)
Density 
1.192±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
Soluble in DMSO.
form 
White solid
pka
0.48±0.30(Predicted)
color 
Yellow
Sensitive 
Light Sensitive
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Alfa Aesar
Product number
J67039
Product name
Tyrphostin AG-1296
Purity
98%
Packaging
5mg
Price
$182
Updated
2021/12/16
Cayman Chemical
Product number
10010592
Product name
AG 1296
Purity
>98%
Packaging
1mg
Price
$28
Updated
2024/03/01
Cayman Chemical
Product number
10010592
Product name
AG 1296
Purity
>98%
Packaging
5mg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
10010592
Product name
AG 1296
Purity
>98%
Packaging
10mg
Price
$207
Updated
2024/03/01
Cayman Chemical
Product number
10010592
Product name
AG 1296
Purity
>98%
Packaging
25mg
Price
$448
Updated
2024/03/01
More
Less

TYRPHOSTIN AG 1296 Chemical Properties,Usage,Production

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-derived growth factor (PDGF) receptor kinase could help in the treatment of atherosclerosis, restenosis, pulmonary fibrosis, and gliomas. AG-1296 is a potent and selective inhibitor of PDGF receptor kinase with an IC50 value of about 0.4 μM both in vitro and in cells (Swiss 3T3 cells). It inhibits ligand-stimulated DNA synthesis in platelet-derived growth factor receptor and stem cell factor/kit receptor transfected cells with an IC50 values of 1.5 and 1.8 μM, respectively. Treatment of sis oncogene transfected NIH3T3 cells with AG-1296 reverses the transformed phenotype.

Uses

Tyrphostin AG 1296, is the platelet-derived growth factor receptor (PDGFR) inhibitor, which can causes growth inhibition in glioblastoma cells.

Definition

ChEBI: 6,7-dimethoxy-2-phenylquinoxaline is a quinoxaline derivative.

target

PDGFR

References

1) Kovalenko et al. (1997), Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296; Biochemistry, 36 6260 2) Krystal et al. (1997), Induction of apoptosis and inhibition of small cell lung cancer growth by the quinoxaline tyrphostins; Cancer Res., 57 220 3) Strutz et al. (2001), TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2); Kidney Int., 59 579

TYRPHOSTIN AG 1296 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

TYRPHOSTIN AG 1296 Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
Jinan Bond Chemical Technology Co., Ltd.
Tel
86-531-88280989
Fax
86-531-88280989
Email
mymail1996@126.com
Country
China
ProdList
256
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19915
Advantage
55
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
More
Less

View Lastest Price from TYRPHOSTIN AG 1296 manufacturers

Career Henan Chemical Co
Product
TYRPHOSTIN AG 1296 146535-11-7
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2019-12-25

146535-11-7, TYRPHOSTIN AG 1296Related Search:


  • TYRPHOSTIN AG 1296
  • AG 1296
  • 6,7-DIMETHOXY-2-PHENYLQUINOXALINE
  • 6,7-DIMETHOXY-3-PHENYLQUINOXALINE
  • Quinoxaline,6,7-dimethoxy-2-phenyl-
  • AG-1296;AG 1296;
  • AG 1296 - CAS 146535-11-7 - Calbiochem
  • AG-1296 (Tyrphostin AG 1296)
  • Tyrphostin AG 1296 (AG 1296)
  • 1296
  • TYRPHOSTIN AG 1296 USP/EP/BP
  • Fms like tyrosine kinase 3,PDGF,Apoptosis,CD117,inhibit,platelet-derived,CD135,SCFR,Tyrphostin AG-1296,c-Kit,PDGFR,FLT3,cell,AG1296,growth,stem,Inhibitor,Tyrphostin AG1296,Cluster of differentiation antigen 135,AG-1296,factor,Platelet-derived growth factor receptor
  • 146535-11-7
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Receptor Tyrosine Kinase Inhibitors
  • Platelet Derived Growth Factor Receptor (PDGFR)
  • Kinase/Phosphatase Biology
  • Inhibitors