ChemicalBook > CAS DataBase List > TYRPHOSTIN B56

TYRPHOSTIN B56

Product Name
TYRPHOSTIN B56
CAS No.
133550-41-1
Chemical Name
TYRPHOSTIN B56
Synonyms
AG 556;(E)-AG 556;TYRPHOSTIN B56;TYRPHOSTIN AG 556;AG 556 (Tyrphostin AG 556);ALPHA-CYANO-(3,4-DIHYDROXY)-N-(4-PHENYLBUTYL)CINNAMIDE;N-(4-PHENYLBUTYL)-3,4-DIHYDROXYBENZYLIDENE-CYANOACETAMIDE;2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)acrylamide;(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)acrylamide;(E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-(4-PHENYLBUTYL)-2-PROPENAMIDE
CBNumber
CB7405611
Molecular Formula
C20H20N2O3
Formula Weight
336.38
MOL File
133550-41-1.mol
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TYRPHOSTIN B56 Property

storage temp. 
−20°C
solubility 
DMSO: soluble
form 
Yellow solid.
color 
Light yellow to yellow
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
A427033
Product name
AG556
Packaging
10mg
Price
$165
Updated
2021/12/16
Usbiological
Product number
254560
Product name
AG 556
Packaging
10mg
Price
$389
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA137620
Product name
AG556
Packaging
25mg
Price
$184
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA137620
Product name
AG556
Packaging
50mg
Price
$300
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA137620
Product name
AG556
Packaging
2mg
Price
$40
Updated
2021/12/16
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TYRPHOSTIN B56 Chemical Properties,Usage,Production

Uses

AG 556 is a highly selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TK inhibitor). AG 556 has been shown to decrease human atrial IKur and cloned hKv1.5 channels by inhibiting EGFR TK.

Biological Activity

Epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 1.1 μ M). Selective over ErbB2 (IC 50 > 500 μ M).

References

[1]. zhang dy, zhang yh, sun hy, et al. epidermal growth factor receptor tyrosine kinase regulates the human inward rectifier potassium k(ir)2.3 channel, stably expressed in hek 293 cells. br j pharmacol, 2011 nov, 164(5): 1469-1478
[1].
[2]. zhang dy, wu w, deng xl, et al. genistein and tyrphostin ag556 inhibit inwardly-rectifying kir2.1 channels expressed in hek 293 cells via protein tyrosine kinase inhibition. biochim biophys acta, 2011, 1808(8): 1993-1999.
[3]. kleinberger-doron n, shelah n, capone r, et al. inhibition of cdk2 activation by selected tyrphostins causes cell cycle arrest at late g1 and s phase. exp cell res, 1998, 241(2): 340-351.
[4]. sevransky je, shaked g, novogrodsky a, et al. tyrphostin ag 556 improves survival and reduces multiorgan failure in canine escherichia coli peritonitis. j clin invest, 1997, 99(8): 1966-1973.

TYRPHOSTIN B56 Preparation Products And Raw materials

Raw materials

Preparation Products

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TYRPHOSTIN B56 Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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69
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
Synchem OHG
Tel
+49 5662 408730
Fax
+49 5662 4087320
Email
info@synchem.de
Country
Germany
ProdList
4705
Advantage
70
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
4420
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8014
Advantage
62
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32038
Advantage
58

133550-41-1, TYRPHOSTIN B56Related Search:


  • ALPHA-CYANO-(3,4-DIHYDROXY)-N-(4-PHENYLBUTYL)CINNAMIDE
  • AG 556
  • (E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-(4-PHENYLBUTYL)-2-PROPENAMIDE
  • N-(4-PHENYLBUTYL)-3,4-DIHYDROXYBENZYLIDENE-CYANOACETAMIDE
  • TYRPHOSTIN B56
  • TYRPHOSTIN AG 556
  • (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-2-propenamide
  • N-(4-Phenylbutyl)-3,4-dihydroxybenzylidenecyanoacetamide, Tyrphostin B56
  • AG 556 (Tyrphostin AG 556)
  • 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)acrylamide
  • 2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-, (2E)-
  • (E)-AG 556
  • (E)-Tyrphostin AG 556,ErbB-1,EGFR,(E)-AG 556,(E)AG 556,Epidermal growth factor receptor,inhibit,Inhibitor,HER1,(E) AG 556
  • (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)acrylamide
  • 133550-41-1
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Kinase/Phosphatase Biology
  • Epidermal Growth Factor Receptor (EGFR)
  • Receptor Tyrosine Kinase Inhibitors
  • Protein Kinase
  • Intracellular Signaling