ChemicalBook > CAS DataBase List > TYRPHOSTIN B56

TYRPHOSTIN B56

Product Name: TYRPHOSTIN B56
CAS No.: 133550-41-1
Chemical Name: TYRPHOSTIN B56
Synonyms: AG 556;(E)-AG 556;TYRPHOSTIN B56;TYRPHOSTIN AG 556;(E-Tyrphostin AG 556);A 556 TYRPHOSTIN B56;(E)-AG 556, 10 mM in DMSO;AG 556 (Tyrphostin AG 556);ALPHA-CYANO-(3,4-DIHYDROXY)-N-(4-PHENYLBUTYL)CINNAMIDE;N-(4-PHENYLBUTYL)-3,4-DIHYDROXYBENZYLIDENE-CYANOACETAMIDE
CBNumber: CB7405611
Molecular Formula: C20H20N2O3
Formula Weight: 336.38
MOL File: 133550-41-1.mol

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TYRPHOSTIN B56 Property

storage temp.: −20°C
solubility: DMSO: soluble
form: Yellow solid.
color: Light yellow to yellow

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: A427033
Product name: AG556
Packaging: 10mg
Price: $165
Updated: 2021/12/16

Usbiological

Product number: 254560
Product name: AG 556
Packaging: 10mg
Price: $389
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA137620
Product name: AG556
Packaging: 25mg
Price: $184
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA137620
Product name: AG556
Packaging: 50mg
Price: $300
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA137620
Product name: AG556
Packaging: 2mg
Price: $40
Updated: 2021/12/16

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TYRPHOSTIN B56 Chemical Properties,Usage,Production

Uses

AG 556 is a highly selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TK inhibitor). AG 556 has been shown to decrease human atrial IKur and cloned hKv1.5 channels by inhibiting EGFR TK.

Biological Activity

Epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 1.1 μ M). Selective over ErbB2 (IC 50 > 500 μ M).

References

[1]. zhang dy, zhang yh, sun hy, et al. epidermal growth factor receptor tyrosine kinase regulates the human inward rectifier potassium k(ir)2.3 channel, stably expressed in hek 293 cells. br j pharmacol, 2011 nov, 164(5): 1469-1478
[1].
[2]. zhang dy, wu w, deng xl, et al. genistein and tyrphostin ag556 inhibit inwardly-rectifying kir2.1 channels expressed in hek 293 cells via protein tyrosine kinase inhibition. biochim biophys acta, 2011, 1808(8): 1993-1999.
[3]. kleinberger-doron n, shelah n, capone r, et al. inhibition of cdk2 activation by selected tyrphostins causes cell cycle arrest at late g1 and s phase. exp cell res, 1998, 241(2): 340-351.
[4]. sevransky je, shaked g, novogrodsky a, et al. tyrphostin ag 556 improves survival and reduces multiorgan failure in canine escherichia coli peritonitis. j clin invest, 1997, 99(8): 1966-1973.

TYRPHOSTIN B56 Preparation Products And Raw materials

Raw materials

Preparation Products

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TYRPHOSTIN B56 Suppliers

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133550-41-1, TYRPHOSTIN B56Related Search:

TYRPHOSTIN AG 879 TYRPHOSTIN AG 1296 AG 957 TYRPHOSTIN AG 1024 TYRPHOSTIN B56 AG 99 CHEMBRDG-BB 9071188 N-PENTYL-3-PHENYL-2-PROPENAMIDE

ALPHA-CYANO-(3,4-DIHYDROXY)-N-(4-PHENYLBUTYL)CINNAMIDE

AG 556

(E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-(4-PHENYLBUTYL)-2-PROPENAMIDE

N-(4-PHENYLBUTYL)-3,4-DIHYDROXYBENZYLIDENE-CYANOACETAMIDE

TYRPHOSTIN B56

TYRPHOSTIN AG 556

(2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-2-propenamide

N-(4-Phenylbutyl)-3,4-dihydroxybenzylidenecyanoacetamide, Tyrphostin B56

AG 556 (Tyrphostin AG 556)

2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)acrylamide

2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)-, (2E)-

(E)-AG 556

(E)-Tyrphostin AG 556,ErbB-1,EGFR,(E)-AG 556,(E)AG 556,Epidermal growth factor receptor,inhibit,Inhibitor,HER1,(E) AG 556

(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)acrylamide

A 556 TYRPHOSTIN B56

(E)-AG 556, 10 mM in DMSO

(E-Tyrphostin AG 556)

133550-41-1

Cell Signaling and Neuroscience

Cell Biology

BioChemical

Kinase/Phosphatase Biology

Epidermal Growth Factor Receptor (EGFR)

Receptor Tyrosine Kinase Inhibitors

Protein Kinase

Intracellular Signaling