TYRPHOSTIN B56
- Product Name
- TYRPHOSTIN B56
- CAS No.
- 133550-41-1
- Chemical Name
- TYRPHOSTIN B56
- Synonyms
- AG 556;(E)-AG 556;TYRPHOSTIN B56;TYRPHOSTIN AG 556;AG 556 (Tyrphostin AG 556);ALPHA-CYANO-(3,4-DIHYDROXY)-N-(4-PHENYLBUTYL)CINNAMIDE;N-(4-PHENYLBUTYL)-3,4-DIHYDROXYBENZYLIDENE-CYANOACETAMIDE;2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)acrylamide;(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(4-phenylbutyl)acrylamide;(E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-(4-PHENYLBUTYL)-2-PROPENAMIDE
- CBNumber
- CB7405611
- Molecular Formula
- C20H20N2O3
- Formula Weight
- 336.38
- MOL File
- 133550-41-1.mol
TYRPHOSTIN B56 Property
- storage temp.
- −20°C
- solubility
- DMSO: soluble
- form
- Yellow solid.
- color
- Light yellow to yellow
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P391Collect spillage. Hazardous to the aquatic environment
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A427033
- Product name
- AG556
- Packaging
- 10mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 254560
- Product name
- AG 556
- Packaging
- 10mg
- Price
- $389
- Updated
- 2021/12/16
- Product number
- FA137620
- Product name
- AG556
- Packaging
- 25mg
- Price
- $184
- Updated
- 2021/12/16
- Product number
- FA137620
- Product name
- AG556
- Packaging
- 50mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- FA137620
- Product name
- AG556
- Packaging
- 2mg
- Price
- $40
- Updated
- 2021/12/16
TYRPHOSTIN B56 Chemical Properties,Usage,Production
Uses
AG 556 is a highly selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TK inhibitor). AG 556 has been shown to decrease human atrial IKur and cloned hKv1.5 channels by inhibiting EGFR TK.
Biological Activity
Epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 1.1 μ M). Selective over ErbB2 (IC 50 > 500 μ M).
References
[1]. zhang dy, zhang yh, sun hy, et al. epidermal growth factor receptor tyrosine kinase regulates the human inward rectifier potassium k(ir)2.3 channel, stably expressed in hek 293 cells. br j pharmacol, 2011 nov, 164(5): 1469-1478
[1].
[2]. zhang dy, wu w, deng xl, et al. genistein and tyrphostin ag556 inhibit inwardly-rectifying kir2.1 channels expressed in hek 293 cells via protein tyrosine kinase inhibition. biochim biophys acta, 2011, 1808(8): 1993-1999.
[3]. kleinberger-doron n, shelah n, capone r, et al. inhibition of cdk2 activation by selected tyrphostins causes cell cycle arrest at late g1 and s phase. exp cell res, 1998, 241(2): 340-351.
[4]. sevransky je, shaked g, novogrodsky a, et al. tyrphostin ag 556 improves survival and reduces multiorgan failure in canine escherichia coli peritonitis. j clin invest, 1997, 99(8): 1966-1973.