TYRPHOSTIN AG 1296

ChemicalBook > CAS DataBase List > TYRPHOSTIN AG 1296

Product Name: TYRPHOSTIN AG 1296
CAS No.: 146535-11-7
Chemical Name: TYRPHOSTIN AG 1296
Synonyms: 1296;AG 1296;AG-1296;AG 1296;;TYRPHOSTIN AG 1296;TYRPHOSTIN AG 1296 USP/EP/BP;Tyrphostin AG 1296 (AG 1296);AG-1296 (Tyrphostin AG 1296);6,7-DIMETHOXY-3-PHENYLQUINOXALINE;6,7-DIMETHOXY-2-PHENYLQUINOXALINE;Quinoxaline,6,7-dimethoxy-2-phenyl-
CBNumber: CB7435034
Molecular Formula: C16H14N2O2
Formula Weight: 266.29
MOL File: 146535-11-7.mol

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TYRPHOSTIN AG 1296 Property

Boiling point:: 420.2±40.0 °C(Predicted)
Density: 1.192±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in DMSO.
form: White solid
pka: 0.48±0.30(Predicted)
color: Yellow
Sensitive: Light Sensitive
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J67039
Product name: Tyrphostin AG-1296
Purity: 98%
Packaging: 5mg
Price: $182
Updated: 2021/12/16

Cayman Chemical

Product number: 10010592
Product name: AG 1296
Purity: >98%
Packaging: 1mg
Price: $28
Updated: 2024/03/01

Cayman Chemical

Product number: 10010592
Product name: AG 1296
Purity: >98%
Packaging: 5mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 10010592
Product name: AG 1296
Purity: >98%
Packaging: 10mg
Price: $207
Updated: 2024/03/01

Cayman Chemical

Product number: 10010592
Product name: AG 1296
Purity: >98%
Packaging: 25mg
Price: $448
Updated: 2024/03/01

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TYRPHOSTIN AG 1296 Chemical Properties,Usage,Production

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors specific for platelet-derived growth factor (PDGF) receptor kinase could help in the treatment of atherosclerosis, restenosis, pulmonary fibrosis, and gliomas. AG-1296 is a potent and selective inhibitor of PDGF receptor kinase with an IC₅₀ value of about 0.4 μM both in vitro and in cells (Swiss 3T3 cells). It inhibits ligand-stimulated DNA synthesis in platelet-derived growth factor receptor and stem cell factor/kit receptor transfected cells with an IC₅₀ values of 1.5 and 1.8 μM, respectively. Treatment of sis oncogene transfected NIH3T3 cells with AG-1296 reverses the transformed phenotype.

Uses

Tyrphostin AG 1296, is the platelet-derived growth factor receptor (PDGFR) inhibitor, which can causes growth inhibition in glioblastoma cells.

Definition

ChEBI: 6,7-dimethoxy-2-phenylquinoxaline is a quinoxaline derivative.

target

PDGFR

References

1) Kovalenko et al. (1997), Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296; Biochemistry, 36 6260 2) Krystal et al. (1997), Induction of apoptosis and inhibition of small cell lung cancer growth by the quinoxaline tyrphostins; Cancer Res., 57 220 3) Strutz et al. (2001), TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2); Kidney Int., 59 579

TYRPHOSTIN AG 1296 Preparation Products And Raw materials

Raw materials

Preparation Products

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TYRPHOSTIN AG 1296 Suppliers

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View Lastest Price from TYRPHOSTIN AG 1296 manufacturers

Career Henan Chemical Co

Product: TYRPHOSTIN AG 1296 146535-11-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

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TYRPHOSTIN AG 1296

AG 1296

6,7-DIMETHOXY-2-PHENYLQUINOXALINE

6,7-DIMETHOXY-3-PHENYLQUINOXALINE

Quinoxaline,6,7-dimethoxy-2-phenyl-

AG-1296;AG 1296;

AG 1296 - CAS 146535-11-7 - Calbiochem

AG-1296 (Tyrphostin AG 1296)

Tyrphostin AG 1296 (AG 1296)

1296

TYRPHOSTIN AG 1296 USP/EP/BP

Fms like tyrosine kinase 3,PDGF,Apoptosis,CD117,inhibit,platelet-derived,CD135,SCFR,Tyrphostin AG-1296,c-Kit,PDGFR,FLT3,cell,AG1296,growth,stem,Inhibitor,Tyrphostin AG1296,Cluster of differentiation antigen 135,AG-1296,factor,Platelet-derived growth factor receptor

146535-11-7

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Receptor Tyrosine Kinase Inhibitors

Platelet Derived Growth Factor Receptor (PDGFR)

Kinase/Phosphatase Biology

Inhibitors