2-Hydroxy-4-methylpyridine

Product Name: 2-Hydroxy-4-methylpyridine
CAS No.: 13466-41-6
Chemical Name: 2-Hydroxy-4-methylpyridine
Synonyms: 4-METHYL-2-PYRIDONE;2-HYDROXY-4-PICOLINE;4-METHYL-2-PYRIDINOL;2-Hydroxy-4-Piocoline;4-METHYL-PYRIDIN-2-OL;4-Methylpyridine-2-ol;Hydroxy-4-Methylpyrid;4-METHYL-2(1H)-PYRIDONE;4-METHYL-2(1H)-PYRIDINONE;4-methyl-1H-pyridin-2-one
CBNumber: CB0131742
Molecular Formula: C6H7NO
Formula Weight: 109.13
MOL File: 13466-41-6.mol

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2-Hydroxy-4-methylpyridine Property

Melting point:: 131-134 °C (lit.)
Boiling point:: 186-187 °C/12 mmHg (lit.)
Density: 1.1143 (rough estimate)
refractive index: 1.5444 (estimate)
Flash point:: 186-187°C/12mm
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
pka: pK1:4.529(＋1) (25°C)
color: White to Gray to Brown
BRN: 107082
InChI: InChI=1S/C6H7NO/c1-5-2-3-7-6(8)4-5/h2-4H,1H3,(H,7,8)
InChIKey: YBDRFJXGJQULGH-UHFFFAOYSA-N
SMILES: C1(=O)NC=CC(C)=C1
CAS DataBase Reference: 13466-41-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-40
Safety Statements: 26-37/39-36-22
WGK Germany: 3
HS Code: 29333995

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 365440
Product name: 2-Hydroxy-4-methylpyridine
Purity: 99%
Packaging: 5g
Price: $45
Updated: 2023/06/20

TCI Chemical

Product number: H1052
Product name: 2-Hydroxy-4-methylpyridine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $66
Updated: 2025/07/31

TRC

Product number: H949890
Product name: 2-Hydroxy-4-methylpyridine
Packaging: 250mg
Price: $50
Updated: 2021/12/16

Matrix Scientific

Product number: 134146
Product name: 4-Methyl-1,2-dihydropyridin-2-one
Purity: 95%+
Packaging: 100mg
Price: $53
Updated: 2021/12/16

Matrix Scientific

Product number: 134146
Product name: 4-Methyl-1,2-dihydropyridin-2-one
Purity: 95%+
Packaging: 2.500g
Price: $215
Updated: 2021/12/16

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2-Hydroxy-4-methylpyridine Chemical Properties,Usage,Production

Chemical Properties

off-white to light brown crystalline powder

Uses

2-Hydroxy-4-methylpyridine is an intermediate used to prepare oxobenzopyrancarboxylate derivatives as inhibitors of serine proteases and human leukocyte elastase. It is also used in the synthesis of (indanylamino)(pyridinyloxy)pyrazines and analogs as corticotropin releasing factor type-1 receptor antagonists.

Definition

ChEBI: 2-Hydroxy-4-methylpyridine is a member of methylpyridines.

Synthesis

695-34-1

13466-41-6

The general procedure for the synthesis of 2-hydroxy-4-methylpyridine from 2-amino-4-methylpyridine was as follows: the synthesis of intermediate V-a (4-methylpyridin-2-ol) was carried out with reference to the method reported by Adger et al. in J. Chem. Soc. Perkin Trans. 1, 1988, p2791-2796. Concentrated HCl was added to a 1 L flask containing water (240 mL) and subsequently cooled to 0°C. 2-Amino-4-methylpyridine (30 g, 277 mmol) was added all at once, followed by a dropwise addition of a solution of NaNO2 (20.6 g, 299 mmol) in water (40 mL) over a period of 1 h, ensuring that the internal temperature did not exceed 5 °C. The reaction was carried out at 0 °C by stirring the reaction mixture. The reaction mixture was stirred at 0 °C for 1 h and then heated to 95 °C, held for 15 min and subsequently cooled to room temperature. The pH was adjusted to 6-7 with 50% NaOH aqueous solution (note exothermic) and extracted with EtOAc (4 x 120 mL) while hot. The organic phases were combined, dried with MgSO4, filtered and the solvent evaporated to give a beige crystalline solid intermediate V-a (24.5 g, 81% yield).1H NMR (300 MHz, DMSO-d6) δ 11.31 (s, 1H), 7.23 (d, J = 6.7 Hz, 1H), 6.10 (s, 1H), 6.00 (dd, J = 6.7, 1.2 Hz, 1H). 1.2 Hz, 1H), 2.10 (s, 3H).

References

[1] Patent: WO2013/14170, 2013, A1. Location in patent: Page/Page column 77-78
[2] Chemische Berichte, 1924, vol. 57, p. 794
[3] Organic Syntheses, 2002, vol. 78, p. 51 - 51

2-Hydroxy-4-methylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Hydroxy-4-methylpyridine Suppliers

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View Lastest Price from 2-Hydroxy-4-methylpyridine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Hydroxy-4-methylpyridine 13466-41-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-12

Henan Fengda Chemical Co., Ltd

Product: 2-Hydroxy-4-methylpyridine 13466-41-6
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-09

Dideu Industries Group Limited

Product: 2-Hydroxy-4-methylpyridine 13466-41-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-24

13466-41-6, 2-Hydroxy-4-methylpyridineRelated Search:

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2-HYDROXY-4-PICOLINE

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2-HYDROXY-4-METHYLPYRIDINE (2-HYDROXY-4-PICOLINE)

2-Hydroxy-4-methylpyridine, 98+%

4-Methyl-2-Hydroxypyridine

4-Methyl-2(1H)-pyridinone 4-Methyl-2-pyridinol 4-Methyl-2-pyridone

2-Hydroxy-4-methylpyridine ,97%

4-Methyl-1,2-dihydropyridine-2-one

4-Methylpyridine-2-ol

2-Hydroxy-4-picoline 4-Methyl-2-pyridinol 4-Methyl-2(1H)-pyridinone

2-Hydroxy-4-methylpyridine

Hydroxy-4-Methylpyrid

4-Methyl-1,2-dihydropyridin-2-one

(91914-05-5) 2-hydroxy-4-methylpyridine

2-Hydroxy-4-methylpyridine&gt

2(1H)-Pyridinone, 4-methyl-

2-Hydroxy-4-methylpyridine ISO 9001：2015 REACH

4-methyl-1H-pyridin-2-one

2-hydro-4-methyl pyridine

13466-41-6

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pharmacetical