5-(Hydroxymethyl)-2'-deoxycytidine
- Product Name
- 5-(Hydroxymethyl)-2'-deoxycytidine
- CAS No.
- 7226-77-9
- Chemical Name
- 5-(Hydroxymethyl)-2'-deoxycytidine
- Synonyms
- 5-hmdC;5-Hydroxymethyl-dC;5-hydroxy methyl-2'-dC;5-Hydroxymethyl-2'-deoxycytidine;4-(HydroxyMethyl)-2'-deoxycytidine;2'-deoxy-5-(hydroxyMethyl)cytidine;2'-Deoxy-5-(hydroxymethyl)cytidine>Cytidine, 2'-deoxy-5-(hydroxyMethyl)-;5-hydroxymethyldeoxycytidine monophosphate;4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(hydroxymethyl)pyrimidin-2(1H)-one
- CBNumber
- CB01327931
- Molecular Formula
- C10H15N3O5
- Formula Weight
- 257.24
- MOL File
- 7226-77-9.mol
5-(Hydroxymethyl)-2'-deoxycytidine Property
- Melting point:
- 205°C(lit.)
- Boiling point:
- 575.0±60.0 °C(Predicted)
- Density
- 1.480 g/cm3
- storage temp.
- Store at -20°C
- solubility
- DMF: 5 mg/ml; DMSO: 20 mg/ml; PBS (pH 7.2): 10 mg/ml
- form
- powder to crystal
- pka
- 13.47±0.10(Predicted)
- color
- White to Light yellow
- λmax
- 274nm(H2O)(lit.)
- InChI
- InChI=1S/C10H15N3O5/c11-9-5(3-14)2-13(10(17)12-9)8-1-6(16)7(4-15)18-8/h2,6-8,14-16H,1,3-4H2,(H2,11,12,17)/t6-,7+,8+/m0/s1
- InChIKey
- HMUOMFLFUUHUPE-XLPZGREQSA-N
- SMILES
- OC[C@H]1O[C@@H](N2C=C(CO)C(N)=NC2=O)C[C@@H]1O
- CAS DataBase Reference
- 7226-77-9
Safety
- HS Code
- 2934.99.4400
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D4220
- Product name
- 2'-Deoxy-5-(hydroxymethyl)cytidine
- Purity
- >98.0%(T)
- Packaging
- 50mg
- Price
- $192
- Updated
- 2024/03/01
- Product number
- D4220
- Product name
- 2'-Deoxy-5-(hydroxymethyl)cytidine
- Purity
- >98.0%(T)
- Packaging
- 200mg
- Price
- $636
- Updated
- 2024/03/01
- Product number
- 18162
- Product name
- 5-(Hydroxymethyl)-2’-deoxycytidine
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 18162
- Product name
- 5-(Hydroxymethyl)-2’-deoxycytidine
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 18162
- Product name
- 5-(Hydroxymethyl)-2’-deoxycytidine
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $184
- Updated
- 2024/03/01
5-(Hydroxymethyl)-2'-deoxycytidine Chemical Properties,Usage,Production
Description
DNA methylation occurs mainly at the 5’-position of cytosine rings (5-methylcytosine) and occurs almost exclusively in CpG islands. Another epigenetic modification in DNA has been recently identified that involves hydroxymethylation of this same base (5-hydroxymethylcytosine), which potentially offers another level of transcriptional control. 5-(Hydroxymethyl)-2’-deoxycytidine is a modified pyrimidine that is capable of producing interstrand cross-links in double-stranded DNA and has been used to quantify DNA hydroxymethylation levels in biological samples.
Uses
5-(Hydroxymethyl)-2’-deoxycytidine is a modified pyrimidine that is capable of producing interstrand cross-links in double-stranded DNA and has been used to quantify DNA hydroxymethylation levels in biological samples.[Cayman Chemical]
Biological Functions
5-(hydroxymethyl)-2'-deoxycytidine (5-hmdC), the oxidative product from 5- (methyl)-2'-deoxycytidine (5-mdC) by TET protein, plays critical roles in a variety of physiological processes such as DNA demethylation, cellular differentiation, and epigenetic regulation, etc. In addition, 5-hmdC has also been demonstrated as a potential biomarker reflecting the diagnosis and prognosis of multiple diseases. Some studies have reported that the level of 5-hmdC significantly decreases in diversified cancers, which suggests its important role in tumor formation and development. In 2009, breakthrough studies found that the 5-hmdC is not the unique oxidative product of 5-mdC. 5-(hydroxymethyl)-2'-deoxycytidine is a crucial intermediate product of the DNA demethylation pathway, which can act as potential biomarkers reflecting the diagnosis and prognosis in multiple tumors. 5-hmdC in human urine is in the form of single deoxynucleosides produced by DNA degradation or metabolism, which can avoid digestion. 5-hmdC has been identified in human urine[1].
References
[1] Mengzhe Guo. “Enrichment and Quantitative Determination of 5-(Hydroxymethyl)-2′-deoxycytidine, 5-(Formyl)-2′-deoxycytidine, and 5-(Carboxyl)-2′-deoxycytidine in Human Urine of Breast Cancer Patients by Magnetic Hyper-Cross-Linked Microporous Polymers Based on Polyionic Liquid.” Analytical Chemistry 90 6 (2018): 3906–3913.
5-(Hydroxymethyl)-2'-deoxycytidine Preparation Products And Raw materials
Raw materials
Preparation Products
5-(Hydroxymethyl)-2'-deoxycytidine Suppliers
- Tel
- 0371-65325800 13700860222
- haifeng.zhang@pannacean.com
- Country
- China
- ProdList
- 397
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-64757213
- Fax
- 86-21-64700613
- info@hongene.com
- Country
- China
- ProdList
- 672
- Advantage
- 61
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24539
- Advantage
- 81
- Tel
- Country
- China
- ProdList
- 42982
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32344
- Advantage
- 50
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10269
- Advantage
- 58
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9636
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9709
- Advantage
- 58
- Tel
- 021-021-52271985 17721149837
- Fax
- +86 (21) 52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 19806
- Advantage
- 60
- Tel
- 025-58851090 13611564524
- Fax
- (6)02557626880
- lwan@aikonchem.com
- Country
- China
- ProdList
- 15952
- Advantage
- 58
- Tel
- 19308655899
- Fax
- -
- 2677609105@qq.com
- Country
- China
- ProdList
- 464
- Advantage
- 58
- Tel
- 15966937598
- Fax
- 3407640895 3071519937
- 3407650895@qq.com
- Country
- China
- ProdList
- 982
- Advantage
- 58
- Tel
- 400-9205774
- sales@glpbio.cn
- Country
- China
- ProdList
- 6870
- Advantage
- 58
- Tel
- +86-400-002-6226 13028896684
- sales@rrkchem.com
- Country
- China
- ProdList
- 55896
- Advantage
- 58
- Tel
- 0371-85513397
- info@granlen.com
- Country
- China
- ProdList
- 1842
- Advantage
- 58
- Tel
- +86-0571-86912261 +8613735419629
- sales@newcanbio.com
- Country
- China
- ProdList
- 9975
- Advantage
- 58
- Tel
- +86-27-87465837 +8618971612321
- Fax
- 86 27 87772287
- info@finetechnology-ind.com
- Country
- China
- ProdList
- 9635
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11289
- Advantage
- 58
- Tel
- 0755-61348847 17820674378
- Fax
- 0755-21016893
- 2682116078@qq.com
- Country
- China
- ProdList
- 7844
- Advantage
- 58
- Tel
- 0512-66317708 13372112871
- huijuan@zitrans.cn
- Country
- China
- ProdList
- 1282
- Advantage
- 58
- Tel
- 13522808617
- omiget@qq.com
- Country
- China
- ProdList
- 9213
- Advantage
- 58
- Tel
- 021-18721550-091 18721550091
- Fax
- 微信18721550091
- yangdong@pharma.com
- Country
- China
- ProdList
- 4123
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8141
- Advantage
- 58
- Tel
- 0532-83818797 18561885118
- market@tlwb.com.cn
- Country
- China
- ProdList
- 3946
- Advantage
- 58
- Tel
- 021-4007787-550 400-7787-550
- 2850202386@qq.com
- Country
- China
- ProdList
- 10618
- Advantage
- 58
- Tel
- 021-61109150
- Fax
- 021-61105897
- sales@tcisct.com
- Country
- China
- ProdList
- 31163
- Advantage
- 58
- Tel
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29778
- Advantage
- 58
- Tel
- +86-027-59232304 15387063101
- 2881924050@qq.com
- Country
- China
- ProdList
- 9892
- Advantage
- 58
- Tel
- 010 61241352 18901327973
- 834537306@qq.com
- Country
- China
- ProdList
- 3798
- Advantage
- 58
- Tel
- 4001650900 13817534909
- 3003940895@qq.com
- Country
- China
- ProdList
- 9345
- Advantage
- 58
- Tel
- 021-50706066 15221275939
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 29803
- Advantage
- 58
- Tel
- 17717235263
- cindy.yang@lgcgroup.com
- Country
- China
- ProdList
- 11572
- Advantage
- 58
- Tel
- 18729005399
- 78282739@qq.com
- Country
- China
- ProdList
- 2302
- Advantage
- 58
- Tel
- 0573-85609002 18157336032
- zhejia01@163.com
- Country
- China
- ProdList
- 7858
- Advantage
- 58
- Tel
- 18621169109
- market03@meryer.com
- Country
- China
- ProdList
- 27996
- Advantage
- 58
- Tel
- 400-618-1121
- Fax
- 400-618-1121
- sales@townyuan.com
- Country
- China
- ProdList
- 2984
- Advantage
- 58
- Tel
- 15981919713
- sales@chemprize.com
- Country
- China
- ProdList
- 408
- Advantage
- 58
- Tel
- 17691182729 15529505138
- 1021@dideu.com
- Country
- China
- ProdList
- 9997
- Advantage
- 58
- Tel
- 13053322091 13053322091
- admin@mopaikeji.com
- Country
- China
- ProdList
- 10974
- Advantage
- 58
- Tel
- 0512-66317708 13372112871
- huijuan@zitrans.cn
- Country
- China
- ProdList
- 1692
- Advantage
- 58
- Tel
- +86-18521732826
- market@aladdin-e.com
- Country
- China
- ProdList
- 48467
- Advantage
- 58
- Tel
- 021-67108196 17317252826
- yang.li@xhmedic.com
- Country
- China
- ProdList
- 466
- Advantage
- 58
- Tel
- 18518950109
- jason_gao@yl-pharminblock.com
- Country
- China
- ProdList
- 1942
- Advantage
- 58
- Tel
- 0371-55159968 18137130222
- haifeng.zhang@pannacean.com
- Country
- China
- ProdList
- 409
- Advantage
- 58
- Tel
- +undefined18600731423
- jason_gao@yl-pharminblock.com
- Country
- China
- ProdList
- 1944
- Advantage
- 58
- Tel
- +86-86-0371-56768238 +8615981919713
- sales@chemprize.com
- Country
- China
- ProdList
- 297
- Advantage
- 58
- Tel
- +86-755-89396905 +86-15013857715
- admin@nexconn.com
- Country
- China
- ProdList
- 10248
- Advantage
- 58
- Tel
- +86-0533-2185556 +8617865335152
- Mandy@hangyubiotech.com
- Country
- China
- ProdList
- 11013
- Advantage
- 58
- Tel
- +86-025-025-85281586 +8618651653755
- Fax
- 025-68661290
- sales@kindchem.cn
- Country
- China
- ProdList
- 1227
- Advantage
- 58