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2,2-Bis(hydroxymethyl)propionic acid

Product Name
2,2-Bis(hydroxymethyl)propionic acid
CAS No.
4767-03-7
Chemical Name
2,2-Bis(hydroxymethyl)propionic acid
Synonyms
DMPA;DIMETHYLOLPROPIONIC ACID;3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoic acid;Bis-MPA;2,2-DIMETHYLOLPROPIONIC ACID;2,2-Bis(methylol)propionic acid;Bis(hydroxymethyl)propionic acid;2,2-bis(hydroxymethyl)propanoicacid;Propanoic acid, 3-hydroxy-2-(hydroxymethyl)-2-methyl-;DMPA(R)
CBNumber
CB1759235
Molecular Formula
C5H10O4
Formula Weight
134.13
MOL File
4767-03-7.mol
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2,2-Bis(hydroxymethyl)propionic acid Property

Melting point:
189-191 °C(lit.)
Boiling point:
167.23°C (rough estimate)
Density 
0.84
vapor density 
<1 (vs air)
refractive index 
1.4240 (estimate)
Flash point:
>150°C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
H2O: soluble
form 
Crystalline Powder
pka
4.16±0.15(Predicted)
color 
White
PH
2.6 (50g/l, H2O, 20℃)
Water Solubility 
soluble
Sensitive 
Hygroscopic
Merck 
14,3253
BRN 
1756385
Stability:
Stable. Hygroscopic.
InChI
1S/C5H10O4/c1-5(2-6,3-7)4(8)9/h6-7H,2-3H2,1H3,(H,8,9)
InChIKey
PTBDIHRZYDMNKB-UHFFFAOYSA-N
SMILES
CC(CO)(CO)C(O)=O
CAS DataBase Reference
4767-03-7(CAS DataBase Reference)
NIST Chemistry Reference
2,2-Bis(hydroxymethyl)propionic acid(4767-03-7)
EPA Substance Registry System
Dimethylolpropionic acid (4767-03-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-36/37
Safety Statements 
26-37/39
WGK Germany 
3
RTECS 
UA2465265
3-9
Autoignition Temperature
>300 °C
Hazard Note 
Irritant
TSCA 
TSCA listed
HS Code 
29159000
Storage Class
11 - Combustible Solids
Hazard Classifications
Eye Irrit. 2
Toxicity
LD50 orally in Rabbit: > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.14996
Product name
2,2-Bis(hydroxymethyl)propionic acid
Purity
for synthesis
Packaging
250g
Price
$82.9
Updated
2025/07/31
Sigma-Aldrich
Product number
8.14996
Product name
2,2-Bis(hydroxymethyl)propionic acid
Purity
for synthesis
Packaging
1kg
Price
$210
Updated
2025/07/31
Sigma-Aldrich
Product number
106615
Product name
2,2-Bis(hydroxymethyl)propionic acid
Purity
98%
Packaging
3kg
Price
$196
Updated
2025/07/31
Sigma-Aldrich
Product number
106615
Product name
2,2-Bis(hydroxymethyl)propionic acid
Purity
98%
Packaging
12kg
Price
$541
Updated
2025/07/31
TCI Chemical
Product number
B1192
Product name
2,2-Bis(hydroxymethyl)propionic Acid
Purity
>97.0%(T)
Packaging
25g
Price
$19
Updated
2025/07/31
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2,2-Bis(hydroxymethyl)propionic acid Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

2,2-bis(hydroxymethyl)propionic acid (DMPA) is a versatile organic materials. it is used as water-based polyurethane chain extender, also make the polyurethane obtained from emulsifying properties, excellent stability can be made self-emulsifying aqueous polyurethane. For preparation a photosensitive resin and liquid crystal materials; for epoxy ester coatings, polyurethane elastomers and powder coatings; Preparation of magnetic recording materials and adhesives etc..

Uses

2,2-Bis(hydroxymethyl)propionic acid is commonly used as an AB2 monomer for the synthesis of hyperbranched (hb) polymers and dendrimers.

Uses

In preparation of water-sol alkyl resins.

Definition

ChEBI: 2,2-Bis(hydroxymethyl)propionic acid is a 3-hydroxy carboxylic acid.

Synthesis

2,2-dihydroxypropionic acid preparation method steps are as follows:
Add 980Kg of pure water in 3000L reactor, put 16Kg of activated carbon loaded sodium hydroxide, add 1000Kg of formaldehyde, drop 300Kg of n-propanal, drop finished for 20-60?? constant temperature 6-14h;
Add 10Kg of formic acid to neutralize the pH value between 6 and 7.2;
Transfer to oxidizing kettle, concentrate in oxidizing kettle under reduced pressure, recover part of unreacted formaldehyde;
Add 580Kg of hydrogen peroxide at elevated temperature, and carry out constant temperature of 60-90?? for 6-10h after dropping;
Add 400Kg to 800Kg of water, and concentrate under reduced pressure;
Concentrate to water between 5—8%, cool and crystallize, centrifuge to get 2,2-dihydroxymethylpropionic acid crude product. The mother liquor was filtered for recirculation recrystallization;
Add 1000kg of water to 1000kg of crude product, warm it up to 50-60?? with stirring, add a small amount of iron remover and about 5kg of activated carbon, and filter it after half an hour to remove the activated carbon. Concentrate again at atmospheric pressure to the water content between 25wt%~30wt% discharge cooling crystallization, and then centrifugation, drying and sieving and other treatments to get 2,2-dihydroxymethylpropionic acid product.
The crude mother liquor is re-concentrated and then recrystallized to extract the product again; the fine mother liquor is then concentrated, decolorized, crystallized, centrifuged and dried to recover the product again. The refined mother liquor is recycled and returned as crude mother liquor. The crude mother liquor after extracting products again is finally treated as waste water. The mother liquor after each filtration was well treated to recover 2,2-dihydroxymethylbutyric acid in the mother liquor and improve the product yield.

2,2-Bis(hydroxymethyl)propionic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2,2-Bis(hydroxymethyl)propionic acid Suppliers

Huzhou Changsheng Chemical Co., Ltd.
Tel
0572-3731402 13757296891
Email
13666501536@126.com
Country
China
ProdList
1
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58
Hubei Guangao Biotechnology Co., Ltd
Tel
027-02702759223056 18162699093
Fax
027-59223056
Email
1208480011@qq.com
Country
China
ProdList
9729
Advantage
58
Shanghai ideal Industrial Co., Ltd.
Tel
021-58957966 18930537195
Fax
021-60899437
Email
wouchina@126.com
Country
China
ProdList
3027
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58
Guangzhou Rui Lion Biotechnology Co., LTD
Tel
13168345686 17306666488
Email
607141423@qq.com
Country
China
ProdList
1739
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58
Zhengzhou HongSheng Pharmaceutical Co., Ltd.
Tel
0371-0371-13526885213 15637198702
Fax
0371-63709726
Email
hsyykjchem@163.com
Country
China
ProdList
3912
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Shandong Mingde Biotechnology Co., Ltd
Tel
15564477061
Email
1397986535@qq.com
Country
China
ProdList
291
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
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69
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
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View Lastest Price from 2,2-Bis(hydroxymethyl)propionic acid manufacturers

Nexal Inc
Product
2,2-Dimethylolpropionic Acid 4767-03-7
Price
US $28.00/kg
Min. Order
300kg
Purity
≥99% Industrial Grade
Supply Ability
20 tons
Release date
2025-07-14
Yunjian (Guangzhou) Import Export Trade Co., Ltd
Product
2,2-Bis(hydroxymethyl)propanoic acid 4767-03-7
Price
US $0.00/kg
Min. Order
230kg
Purity
99%
Supply Ability
200000
Release date
2025-05-27
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-2-Dimethylolpropionic acid 4767-03-7
Price
US $100.00/KG
Min. Order
1KG
Purity
99%min
Supply Ability
200TON
Release date
2024-10-24

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