2-PHENYLPROPIONIC ACID

Product Name: 2-PHENYLPROPIONIC ACID
CAS No.: 492-37-5
Chemical Name: 2-PHENYLPROPIONIC ACID
Synonyms: HYDRATROPIC ACID;Benzeneacetic acid, .alpha.-methyl-;2-Phenylproplonic Acid;(±)-α-methylphenylaceticacid;(±)-2-Phenylpropionic acid, (±)-Hydratropic acid;dl-PPA;2-Phenylpropionic;RARECHEM AL BO 0089;TIMTEC-BB SBB007855;DL-HYDRATROPIC ACID
CBNumber: CB9293539
Molecular Formula: C9H10O2
Formula Weight: 150.18
MOL File: 492-37-5.mol

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2-PHENYLPROPIONIC ACID Property

Melting point:: 5 °C
Boiling point:: 260-262 °C (lit.)
Density: 1.1 g/mL at 25 °C (lit.)
refractive index: n20/D 1.522(lit.)
Flash point:: >230 °F
storage temp.: Sealed in dry,Room Temperature
solubility: 9.9g/l
form: Liquid
pka: 4.34±0.10(Predicted)
color: Clear pale yellow to yellow
PH: 3 (5g/l, H2O, 20℃)
Water Solubility: 10 g/L (20 ºC)
BRN: 1863558
LogP: 1.699 (est)
CAS DataBase Reference: 492-37-5(CAS DataBase Reference)
NIST Chemistry Reference: Benzeneacetic acid, «alpha»-methyl-(492-37-5)
EPA Substance Registry System: Benzeneacetic acid, .alpha.-methyl- (492-37-5)

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Safety

Hazard Codes: Xi,C
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
TSCA: Yes
HS Code: 29163900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P31701
Product name: 2-Phenylpropionic acid
Purity: 97%
Packaging: 5g
Price: $41.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: P31701
Product name: 2-Phenylpropionic acid
Purity: 97%
Packaging: 10g
Price: $80.3
Updated: 2024/03/01

TCI Chemical

Product number: P0699
Product name: DL-2-Phenylpropionic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $16
Updated: 2024/03/01

TCI Chemical

Product number: P0699
Product name: DL-2-Phenylpropionic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $44
Updated: 2024/03/01

Alfa Aesar

Product number: L00709
Product name: (±)-2-Phenylpropionic acid, 98%
Packaging: 5g
Price: $33.65
Updated: 2024/03/01

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2-PHENYLPROPIONIC ACID Chemical Properties,Usage,Production

Chemical Properties

clear pale yellow to yellow liquid

Uses

2-Phenylpropionic acid is used in the preparation of ibuprofen derivatives for their anti-inflammatory activity. Also used in nucleation inhibitors in Dutch resolution of diastereomers.

Definition

ChEBI: A 2-arylpropionic acid carrying a phenyl group at position 2. It is a metabolite of alpha-methylstyrene (AMS), a volatile hydrocarbon.

Synthesis Reference(s)

Journal of the American Chemical Society, 99, p. 182, 1977 DOI: 10.1021/ja00443a033
The Journal of Organic Chemistry, 51, p. 4354, 1986 DOI: 10.1021/jo00373a005
Tetrahedron Letters, 21, p. 581, 1980 DOI: 10.1016/S0040-4039(01)85562-3

Synthesis

2-Phenylpropionic acid is prepared:
1) from Benzyl cyanide by Metbylation with Methyl iodide and Sodamide to produce alpha-Phenylpropionitrile, from which the acid is produced by acid hydrolysis.
2) from Acetophenone cyanhydrin with Hydriodic acid.

Purification Methods

Fractionally distil the acid, or recrystallise it from pet ether (b 40-60o) with strong cooling (see references below). [Beilstein 9 II 348.]

2-PHENYLPROPIONIC ACID Preparation Products And Raw materials

Raw materials

Benzeneacetonitrile Phenylacetic acid

Preparation Products

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2-PHENYLPROPIONIC ACID Suppliers

Americas 1 Belgium 2 Canada 3 China 298 Europe 3 France 2 Germany 8 India 13 Japan 6 Norway 1 Poland 1 Slovakia 1 South Korea 2 Switzerland 3 Ukraine 2 United Kingdom 12 United States 46 Global 404

Changzhou Tianhua Pharmaceutical Co., Ltd.

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Email: tianhua@tianhuachem.com
Country: China
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Nanjing Jubai Biomedical Technology Co., Ltd.

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Email: 235694118@qq.com
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Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883 15367835770
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Email: viola@huatengsci.com
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Changzhou Ansciep Chemical Co., Ltd.

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J & K SCIENTIFIC LTD.

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Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
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TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
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TCI (Shanghai) Development Co., Ltd.

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Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
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ProdList: 8418
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View Lastest Price from 2-PHENYLPROPIONIC ACID manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2-PHENYLPROPIONIC ACID 492-37-5
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-11-18

airuikechemical co., ltd.

Product: DL-2-Phenylpropionic acid 492-37-5
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 20 tons
Release date: 2024-04-07

Hebei Weibang Biotechnology Co., Ltd

Product: 2-PHENYLPROPIONIC ACID 492-37-5
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-14

492-37-5, 2-PHENYLPROPIONIC ACIDRelated Search:

(S)-(+)-2-Phenylpropionic acid Clobetasol propionate 2-Methylbenzyl cyanide 1-Phenyl-2-nitropropene Testosterone propionate 2-Phenylphenol Calcium Propionate 3-Bromopropionic acid Triphenylphosphine Folic acid Nandrolone phenylpropionate Hyaluronic acid 2-PHENYLPROPIONALDEHYDE Citric acid Ethyl 2-(Chlorosulfonyl)acetate 2,3-Dibromopropionic acid Malic acid Ascoric Acid

Benzeneacetic acid, .alpha.-methyl-

(n)-2-phenylpropionic acid

(n)-à-methylphenylacetic acid

2-HENYLPROPIONIC ACID

2-PHENYLPROPINICACID

dl-PPA

α-methyl-α-toluic acid

2-PHENYLPROPIONIC ACID 98%

(±)-2-Phenylpropionic acid, (±)-Hydratropic acid

DL-α-phenylpropionic acid

a-Methylbenzeneacetic acid

rac-(2R*)-2-Phenylpropionic acid

rac-(R*)-2-Phenylpropanoic acid

DL-2-Phenylpropionic acid,98%

RARECHEM AL BO 0089

(+/-)-2-PHENYLPROPIONIC ACID

2-PHENYLPROPIONIC ACID

α-methylbenzeneaceticacid

α-methylphenylaceticacid

TIMTEC-BB SBB007855

a-Methylphenylacetic acid

ALPHA-METHYLPHENYLACETIC ACID

HYDRATROPIC ACID 95% (GC)

(+/-)-2-Phenylpropionicacid,98%

2-Phenylpropionic

(+/-)-HYDRATROPIC ACID

HYDRATROPIC ACID

DL-HYDRATROPIC ACID

DL-2-PHENYLPROPIONIC ACID

DL-2-Phenylpropionic acid, 98% 10GR

2-Phenylpropionic Acid, 97+%

(±)-α-methylphenylaceticacid

(RS)-2-phenylpropionicacid

alpha-Methylbenzeneacetic acid

alpha-methyl-benzeneaceticaci

alpha-Phenylpropionic acid

benzeneaceticacid,α-methyl-

dl-alpha-Phenylpropionic acid

Propanoic acid, 2-phenyl

(2S)-2-phenylpropanoate

2-Phenylproplonic Acid

DL-2-PhenylpropionicAcid&gt

2-pronyl propionic acid

Benzeneacetic acid, α-methyl-

492-37-5

CH3CHC6H5COOH

C6H5CHCH3COOH

Carbonyl Compounds

C9

Carboxylic Acids

Building Blocks

Organic Building Blocks

CARBOXYLIC ACID

Carboxylic Acids

Aliphatics

Carboxylic Acids

Organic acids

Pharmaceutical Intermediates