ChemicalBook > CAS DataBase List > 2-PHENYLPROPIONIC ACID

2-PHENYLPROPIONIC ACID

Product Name
2-PHENYLPROPIONIC ACID
CAS No.
492-37-5
Chemical Name
2-PHENYLPROPIONIC ACID
Synonyms
HYDRATROPIC ACID;Benzeneacetic acid, .alpha.-methyl-;2-Phenylproplonic Acid;(±)-α-methylphenylaceticacid;(±)-2-Phenylpropionic acid, (±)-Hydratropic acid;dl-PPA;2-Phenylpropionic;RARECHEM AL BO 0089;TIMTEC-BB SBB007855;DL-HYDRATROPIC ACID
CBNumber
CB9293539
Molecular Formula
C9H10O2
Formula Weight
150.18
MOL File
492-37-5.mol
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2-PHENYLPROPIONIC ACID Property

Melting point:
5 °C
Boiling point:
260-262 °C (lit.)
Density 
1.1 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.522(lit.)
Flash point:
>230 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
9.9g/l
form 
Liquid
pka
4.34±0.10(Predicted)
color 
Clear pale yellow to yellow
PH
3 (5g/l, H2O, 20℃)
Water Solubility 
10 g/L (20 ºC)
BRN 
1863558
LogP
1.699 (est)
CAS DataBase Reference
492-37-5(CAS DataBase Reference)
NIST Chemistry Reference
Benzeneacetic acid, «alpha»-methyl-(492-37-5)
EPA Substance Registry System
Benzeneacetic acid, .alpha.-methyl- (492-37-5)
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Safety

Hazard Codes 
Xi,C
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
3
TSCA 
Yes
HS Code 
29163900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P31701
Product name
2-Phenylpropionic acid
Purity
97%
Packaging
5g
Price
$41.4
Updated
2024/03/01
Sigma-Aldrich
Product number
P31701
Product name
2-Phenylpropionic acid
Purity
97%
Packaging
10g
Price
$80.3
Updated
2024/03/01
TCI Chemical
Product number
P0699
Product name
DL-2-Phenylpropionic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
P0699
Product name
DL-2-Phenylpropionic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$44
Updated
2024/03/01
Alfa Aesar
Product number
L00709
Product name
(±)-2-Phenylpropionic acid, 98%
Packaging
5g
Price
$33.65
Updated
2024/03/01
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2-PHENYLPROPIONIC ACID Chemical Properties,Usage,Production

Chemical Properties

clear pale yellow to yellow liquid

Uses

2-Phenylpropionic acid is used in the preparation of ibuprofen derivatives for their anti-inflammatory activity. Also used in nucleation inhibitors in Dutch resolution of diastereomers.

Definition

ChEBI: A 2-arylpropionic acid carrying a phenyl group at position 2. It is a metabolite of alpha-methylstyrene (AMS), a volatile hydrocarbon.

Synthesis Reference(s)

Journal of the American Chemical Society, 99, p. 182, 1977 DOI: 10.1021/ja00443a033
The Journal of Organic Chemistry, 51, p. 4354, 1986 DOI: 10.1021/jo00373a005
Tetrahedron Letters, 21, p. 581, 1980 DOI: 10.1016/S0040-4039(01)85562-3

Synthesis

2-Phenylpropionic acid is prepared:
1) from Benzyl cyanide by Metbylation with Methyl iodide and Sodamide to produce alpha-Phenylpropionitrile, from which the acid is produced by acid hydrolysis.
2) from Acetophenone cyanhydrin with Hydriodic acid. 

Purification Methods

Fractionally distil the acid, or recrystallise it from pet ether (b 40-60o) with strong cooling (see references below). [Beilstein 9 II 348.]

2-PHENYLPROPIONIC ACID Preparation Products And Raw materials

Raw materials

Benzeneacetonitrile Phenylacetic acid

Preparation Products

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2-PHENYLPROPIONIC ACID Suppliers

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View Lastest Price from 2-PHENYLPROPIONIC ACID manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
2-PHENYLPROPIONIC ACID 492-37-5
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-11-18
Hebei Weibang Biotechnology Co., Ltd
Product
2-PHENYLPROPIONIC ACID 492-37-5
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 mt
Release date
2024-11-14
airuikechemical co., ltd.
Product
DL-2-Phenylpropionic acid 492-37-5
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
20 tons
Release date
2024-04-07

492-37-5, 2-PHENYLPROPIONIC ACIDRelated Search:

(S)-(+)-2-Phenylpropionic acid Clobetasol propionate 2-Methylbenzyl cyanide 1-Phenyl-2-nitropropene Testosterone propionate 2-Phenylphenol Calcium Propionate 3-Bromopropionic acid Triphenylphosphine Folic acid Nandrolone phenylpropionate Hyaluronic acid 2-PHENYLPROPIONALDEHYDE Citric acid Ethyl 2-(Chlorosulfonyl)acetate 2,3-Dibromopropionic acid Malic acid Ascoric Acid

  • Benzeneacetic acid, .alpha.-methyl-
  • (n)-2-phenylpropionic acid
  • (n)-à-methylphenylacetic acid
  • 2-HENYLPROPIONIC ACID
  • 2-PHENYLPROPINICACID
  • dl-PPA
  • α-methyl-α-toluic acid
  • 2-PHENYLPROPIONIC ACID 98%
  • (±)-2-Phenylpropionic acid, (±)-Hydratropic acid
  • DL-α-phenylpropionic acid
  • a-Methylbenzeneacetic acid
  • rac-(2R*)-2-Phenylpropionic acid
  • rac-(R*)-2-Phenylpropanoic acid
  • DL-2-Phenylpropionic acid,98%
  • RARECHEM AL BO 0089
  • (+/-)-2-PHENYLPROPIONIC ACID
  • 2-PHENYLPROPIONIC ACID
  • α-methylbenzeneaceticacid
  • α-methylphenylaceticacid
  • TIMTEC-BB SBB007855
  • a-Methylphenylacetic acid
  • ALPHA-METHYLPHENYLACETIC ACID
  • HYDRATROPIC ACID 95% (GC)
  • (+/-)-2-Phenylpropionicacid,98%
  • 2-Phenylpropionic
  • (+/-)-HYDRATROPIC ACID
  • HYDRATROPIC ACID
  • DL-HYDRATROPIC ACID
  • DL-2-PHENYLPROPIONIC ACID
  • DL-2-Phenylpropionic acid, 98% 10GR
  • 2-Phenylpropionic Acid, 97+%
  • (±)-α-methylphenylaceticacid
  • (RS)-2-phenylpropionicacid
  • alpha-Methylbenzeneacetic acid
  • alpha-methyl-benzeneaceticaci
  • alpha-Phenylpropionic acid
  • benzeneaceticacid,α-methyl-
  • dl-alpha-Phenylpropionic acid
  • Propanoic acid, 2-phenyl
  • (2S)-2-phenylpropanoate
  • 2-Phenylproplonic Acid
  • DL-2-PhenylpropionicAcid&gt
  • 2-pronyl propionic acid
  • Benzeneacetic acid, α-methyl-
  • 492-37-5
  • CH3CHC6H5COOH
  • C6H5CHCH3COOH
  • Carbonyl Compounds
  • C9
  • Carboxylic Acids
  • Building Blocks
  • Organic Building Blocks
  • CARBOXYLIC ACID
  • Carboxylic Acids
  • Aliphatics
  • Carboxylic Acids
  • Organic acids
  • Pharmaceutical Intermediates