2-PHENYLPROPIONIC ACID
- Product Name
- 2-PHENYLPROPIONIC ACID
- CAS No.
- 492-37-5
- Chemical Name
- 2-PHENYLPROPIONIC ACID
- Synonyms
- HYDRATROPIC ACID;Benzeneacetic acid, .alpha.-methyl-;2-Phenylproplonic Acid;(±)-α-methylphenylaceticacid;(±)-2-Phenylpropionic acid, (±)-Hydratropic acid;dl-PPA;2-Phenylpropionic;RARECHEM AL BO 0089;TIMTEC-BB SBB007855;DL-HYDRATROPIC ACID
- CBNumber
- CB9293539
- Molecular Formula
- C9H10O2
- Formula Weight
- 150.18
- MOL File
- 492-37-5.mol
2-PHENYLPROPIONIC ACID Property
- Melting point:
- 5 °C
- Boiling point:
- 260-262 °C (lit.)
- Density
- 1.1 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.522(lit.)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- 9.9g/l
- form
- Liquid
- pka
- 4.34±0.10(Predicted)
- color
- Clear pale yellow to yellow
- PH
- 3 (5g/l, H2O, 20℃)
- Water Solubility
- 10 g/L (20 ºC)
- BRN
- 1863558
- LogP
- 1.699 (est)
- CAS DataBase Reference
- 492-37-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzeneacetic acid, «alpha»-methyl-(492-37-5)
- EPA Substance Registry System
- Benzeneacetic acid, .alpha.-methyl- (492-37-5)
Safety
- Hazard Codes
- Xi,C
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- TSCA
- Yes
- HS Code
- 29163900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
N-Bromosuccinimide Price
- Product number
- P31701
- Product name
- 2-Phenylpropionic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $41.4
- Updated
- 2024/03/01
- Product number
- P31701
- Product name
- 2-Phenylpropionic acid
- Purity
- 97%
- Packaging
- 10g
- Price
- $80.3
- Updated
- 2024/03/01
- Product number
- P0699
- Product name
- DL-2-Phenylpropionic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $16
- Updated
- 2024/03/01
- Product number
- P0699
- Product name
- DL-2-Phenylpropionic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $44
- Updated
- 2024/03/01
- Product number
- L00709
- Product name
- (±)-2-Phenylpropionic acid, 98%
- Packaging
- 5g
- Price
- $33.65
- Updated
- 2024/03/01
2-PHENYLPROPIONIC ACID Chemical Properties,Usage,Production
Chemical Properties
clear pale yellow to yellow liquid
Uses
2-Phenylpropionic acid is used in the preparation of ibuprofen derivatives for their anti-inflammatory activity. Also used in nucleation inhibitors in Dutch resolution of diastereomers.
Definition
ChEBI: A 2-arylpropionic acid carrying a phenyl group at position 2. It is a metabolite of alpha-methylstyrene (AMS), a volatile hydrocarbon.
Synthesis Reference(s)
Journal of the American Chemical Society, 99, p. 182, 1977 DOI: 10.1021/ja00443a033
The Journal of Organic Chemistry, 51, p. 4354, 1986 DOI: 10.1021/jo00373a005
Tetrahedron Letters, 21, p. 581, 1980 DOI: 10.1016/S0040-4039(01)85562-3
Synthesis
2-Phenylpropionic acid is prepared:
1) from Benzyl cyanide by Metbylation with
Methyl iodide and Sodamide to produce alpha-Phenylpropionitrile, from which the
acid is produced by acid hydrolysis.
2) from Acetophenone cyanhydrin with Hydriodic
acid.
Purification Methods
Fractionally distil the acid, or recrystallise it from pet ether (b 40-60o) with strong cooling (see references below). [Beilstein 9 II 348.]
2-PHENYLPROPIONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2-PHENYLPROPIONIC ACID Suppliers
- Tel
- --
- Fax
- --
- chemcontrol@nextra.sk
- Country
- Slovakia
- ProdList
- 6700
- Advantage
- 60
View Lastest Price from 2-PHENYLPROPIONIC ACID manufacturers
- Product
- 2-PHENYLPROPIONIC ACID 492-37-5
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-11-18
- Product
- 2-PHENYLPROPIONIC ACID 492-37-5
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-14
- Product
- DL-2-Phenylpropionic acid 492-37-5
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99.99%
- Supply Ability
- 20 tons
- Release date
- 2024-04-07