ARV-766
- Product Name
- ARV-766
- CAS No.
- 2750830-09-0
- Chemical Name
- ARV-766
- Synonyms
- ARV776;Luxdegalutamide;Luxdegalutamide ARV-766;4-[4-[[1-[4-[[[trans-3-(4-Cyano-3-methoxyphenoxy)-2,2,4,4-tetramethylcyclobutyl]amino]carbonyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-N-[(3S)-2,6-dioxo-3-piperidinyl]-2-fluorobenzamide
- CBNumber
- CB013336286
- Molecular Formula
- C45H54FN7O6
- Formula Weight
- 807.95
- MOL File
- 2750830-09-0.mol
ARV-766 Property
- Boiling point:
- 993.4±65.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
- solubility
- DMSO: Soluble: =10 mg/ml
- form
- Solid
- pka
- 10.58±0.40(Predicted)
- color
- White to off-white
ARV-766 Chemical Properties,Usage,Production
Uses
Luxdegalutamide (ARV-766) is an orally active protein hydrolysis targeted chimeric (PROTAC) targeting androgen receptor (AR), which can degrade AR resistance related mutants, including T878/H875/L702 mutants. Luxdegalutamide has anti-tumor activity and can be used in the study of castration resistant prostate cancer[1][2].
in vivo
Luxdegalutamide exhibits anti-tumor activity in mouse LNCaP and VCaP xenograft models[2].
References
[1] Snyder L, et al. In vitro evaluation of PROTAC? degrader ARV-766 for cytochrome P450-and transporter-mediated drug-drug interaction[J]. Drug Metabolism and Pharmacokinetics, 2024, 55: 100881.
[2] Snyder L, et al. Abstract ND03: Discovery of ARV-766, an androgen receptor degrading PROTAC? for the treatment of men with metastatic castration resistant prostate cancer[J]. Cancer Research, 2023, 83(7_Supplement): ND03-ND03.
ARV-766 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ARV-766 manufacturers
- Product
- Luxdegalutamide (ARV-766) 2750830-09-0
- Price
- US $0.00-0.00/mg
- Min. Order
- 5mg
- Purity
- 98%+ HPLC HNMR
- Supply Ability
- 20g
- Release date
- 2024-03-29