2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol

Product Name: 2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol
CAS No.: 128607-22-7
Chemical Name: 2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol
Synonyms: Ospemifene;CS-1039;Fc-1271a;Ccris 9205;Ospemifene >Unii-B0p231ilbk;2-(4-(4-chloro-1;Ospemifene FC-1271a;The department of pp meters;2-diphenyl-but-1-enyl)phenoxy)ethanol
CBNumber: CB01335273
Molecular Formula: C24H23ClO2
Formula Weight: 378.89
MOL File: 128607-22-7.mol

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2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol Property

Boiling point:: 544.6±50.0 °C(Predicted)
Density: 1.166±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: soluble20mg/mL, clear
pka: 14.26±0.10(Predicted)
form: powder
color: white to beige
InChIKey: LUMKNAVTFCDUIE-VHXPQNKSSA-N
CAS DataBase Reference: 128607-22-7

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Safety

Hazard Codes: N
Risk Statements: 50/53
Safety Statements: 60-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
HS Code: 2909.49.1500
Hazardous Substances Data: 128607-22-7(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0996
Product name: Ospemifene
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $92.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0996
Product name: Ospemifene
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $300
Updated: 2024/03/01

TCI Chemical

Product number: O0441
Product name: Ospemifene
Purity: >98.0%(GC)
Packaging: 100mg
Price: $54
Updated: 2024/03/01

TCI Chemical

Product number: O0441
Product name: Ospemifene
Purity: >98.0%(GC)
Packaging: 1g
Price: $128
Updated: 2024/03/01

Cayman Chemical

Product number: 23755
Product name: Ospemifene
Purity: ≥98%
Packaging: 50mg
Price: $86
Updated: 2024/03/01

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2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol Chemical Properties,Usage,Production

Description

In February 2013, the US FDA approved ospemifene (also referred to as FC1271a), for the treatment ofmoderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy (VVA), due tomenopause. It is estimated that there are 150 million postmenopausal women worldwide with 40–70% suffering from VVA. Ospemifene is a selective estrogen receptor (ER) modulator (SERM) and the first nonhormonal, nonestrogen for the treatment of moderate to severe dyspareunia in women with menopausal VVA. It binds to ERα (IC₅₀～800 nM) and ERβ (IC₅₀～1600 nM) with tissue-specific estrogenic agonist/antagonist effects. Treatment with ospemifene increases the thickness of the vaginal tissue thereby decreasing fragility of the tissue and reducing potential for pain during sexual intercourse.

Originator

Tess Diagnostics and Pharmaceuticals/Hormos Medical/QuatRx (Finland)

Uses

Treatment of vaginal atrophy, osteoporosis, and vasomotor symptoms.

Definition

ChEBI: An organochlorine compound that is a selective estrogen receptor modulator; used for treatment of dyspareunia.

brand name

Osphena

Clinical Use

Ospemifene is a SERM that is currently in Phase II/III clinical trials for the treatment of postmenopausal osteoporosis and urogenital atrophy. It is a known metabolite of toremifene, a triphenylethylene derivative used to treat breast cancer.Ospemifene has been shown to have beneficial effects on the bone without significant estrogen-related side effects. The beneficial effect observed on bone stems from this agent's ability to increase osteoblast proliferation and, as a result, to enhance bone mineralization as well as bone formation. Unlike tamoxifen, ospemifene does not induce osteocyte apoptosis.

Synthesis

The drug can be synthesized succinctly in two steps. First, alkylation of commercially available 4-hydroxybenzophenone (130) with ethylene carbonate and catalytic sodium iodide in refluxing toluene provided benzophenone 131 in 94% yield. This was followed by a McMurry coupling involving benzophenone 131 with chloropropiophenone 132 in the presence of zinc powder and titanium tetrachloride in 2-methyltetrahydrofuran. This reaction gave rise to a mixture of triphenylethylenes directly as a 5.5:1 ratio of Z to E isomers which could be separated by crystallization in aqueous methanol to give a mixture of olefins, 98% of which was comprised of the desired Z-isomer corresponding to ospemifene (XVII). The product purity was further improved by recrystallization to give 99.9% of the Z-isomer in 46% yield from 131. Thus, ospemifene was synthesized in two steps and 43% overall yield.

2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol Suppliers

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View Lastest Price from 2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol manufacturers

R&D Scientific Inc.

Product: Ospemifene 128607-22-7
Price: US $6300.00/Kg
Min. Order: 1Kg
Purity: 99
Supply Ability: 500 Kg
Release date: 2024-04-25

Zhuozhou Wenxi import and Export Co., Ltd

Product: Ospemifene 128607-22-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: Ospemifene 128607-22-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

128607-22-7, 2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanolRelated Search:

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CS-1039

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2-(4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy)ethanol USP/EP/BP

Ospemifene D4Q: What is Ospemifene D4 Q: What is the CAS Number of Ospemifene D4 Q: What is the storage condition of Ospemifene D4 Q: What are the applications of Ospemifene D4

The department of pp meters

128607-22-7

Inhibitors