Raloxifene hydrochloride
- Product Name
- Raloxifene hydrochloride
- CAS No.
- 82640-04-8
- Chemical Name
- Raloxifene hydrochloride
- Synonyms
- CS-127;ly156758;KEOXIFENE;LY 139481;AKOS 92138;RALOXIFENE HCL;LY156758 hydrochloride;LY139481 hydrochloride;Latilavir secondary VI;Evista (Raloxifene HCl)
- CBNumber
- CB6302366
- Molecular Formula
- C28H28ClNO4S
- Formula Weight
- 510.04
- MOL File
- 82640-04-8.mol
Raloxifene hydrochloride Property
- Melting point:
- 250-253°C
- storage temp.
- 2-8°C
- solubility
- DMSO: 28 mg/mL, soluble
- form
- solid
- color
- light yellow
- λmax
- 286nm(lit.)
- Merck
- 14,8098
- BCS Class
- 2
- InChI
- InChI=1S/C28H27NO4S.ClH/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29;/h4-13,18,30-31H,1-3,14-17H2;1H
- InChIKey
- BKXVVCILCIUCLG-UHFFFAOYSA-N
- SMILES
- C1(C(=O)C2C=CC(OCCN3CCCCC3)=CC=2)C2C=CC(O)=CC=2SC=1C1C=CC(O)=CC=1.Cl
- CAS DataBase Reference
- 82640-04-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H351Suspected of causing cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- PHR1852
- Product name
- Raloxifene hydrochloride for peak identification
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 500mg
- Price
- $173
- Updated
- 2024/03/01
- Product number
- 1598201
- Product name
- Raloxifene hydrochloride
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- 27189
- Product name
- Raloxifene (hydrochloride)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $648
- Updated
- 2024/03/01
- Product number
- 10011620
- Product name
- Raloxifene (hydrochloride)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 10011620
- Product name
- Raloxifene (hydrochloride)
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $61
- Updated
- 2024/03/01
Raloxifene hydrochloride Chemical Properties,Usage,Production
Description
Raloxifene was launched as Evista in the US for the prevention of postmenopausal osteoporosis. It is noteworthy that this molecule was formerly under development as keoxifene for breast cancer and prostatic hypertrophy. Raloxifene can be prepared by acylation of 6-methoxy-2-(4-methoxyphenyl) benzothiophene followed by simultaneous demethylation of both methoxy groups. Raloxifen is a selective estrogen receptor modulator, exerting antiestrogenic action on certain tissues (breast) and also estrogenic action on bone metabolism or serum lipids. In normal early postmenopausal women, 200 mg daily produced a trend towards suppression of estrogen effects. Raloxifen impeded bone loss in osteoporosis. A two-year study in postmenopausal women with an increased risk for osteoporosis showed that Raloxifen markedly prevented non-traumatic vertebral fractures. Results of several clinical studies demonstrated that Raloxifen appreciably reduced the risk of developing breast cancer. Moreover, it had favourable effect on lipid profiles without having the potential side-effects of estrogen-based therapies. Several extensions for different uses of this molecule are planned, for example growth disorder, obesity, colon tumor and skin atrophy. No serious drug-related events have been reported in the limited number of clinical trials.
Chemical Properties
Light-Yellow Solid
Originator
Lilly (US)
Uses
Raloxifene hydrochloride can be used as a nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic.
Uses
amino acid, nutrient. A nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic.Insoluble in water.
Uses
Labeled Raloxifene, intended for use as an internal standard for the quantification of Raloxifene by GC- or LC-mass spectrometry.
Definition
ChEBI: A hydrochloride salt resulting from the reaction of equimolar amounts of raloxifene and hydrogen chloride.
brand name
Evista (Lilly).
General Description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Biochem/physiol Actions
Raloxifene is a selective estrogen receptor modulator (SERM); acts as an anti-estrogen in both breast and uterine tissue while being estrogenic in bone. May have efficacy against estrogen-sensitive cancers.
Clinical Use
Treatment and prevention of osteoporosis in post menopausal women
Drug interactions
Potentially hazardous interactions with other drugs
Anticoagulants: antagonism of anticoagulant effect of
coumarins.
Colestyramine: reduced absorption of raloxifene -
avoid.
Metabolism
Raloxifene undergoes extensive first pass metabolism
to the glucuronide conjugates: raloxifene-4'-
glucuronide, raloxifene-6-glucuronide, and raloxifene-6,
4′-diglucuronide.
Raloxifene undergoes enterohepatic recycling, and is
excreted almost entirely in the faeces. Less than 6% of
dose is excreted in the urine.
storage
+4°C (desiccate)
References
[1] obach rs.potent inhibition of human liver aldehyde oxidase by raloxifene.
Raloxifene hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Raloxifene hydrochloride manufacturers
- Product
- Raloxifene hcl 82640-04-8
- Price
- US $100.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 20tons
- Release date
- 2023-10-12
- Product
- Raloxifene Hydrochloride / Keoxifene / Evista 82640-04-8
- Price
- US $40.00/Box
- Min. Order
- 1Box
- Purity
- 99.99%
- Supply Ability
- 10000000000
- Release date
- 2023-12-06
- Product
- Raloxifene hydrochloride 82640-04-8
- Price
- US $3.00-1.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 10 tons
- Release date
- 2024-04-16