Raloxifene hydrochloride

ChemicalBook > CAS DataBase List > Raloxifene hydrochloride

Raloxifene hydrochloride

Product Name: Raloxifene hydrochloride
CAS No.: 82640-04-8
Chemical Name: Raloxifene hydrochloride
Synonyms: CS-127;ly156758;KEOXIFENE;LY 139481;AKOS 92138;RALOXIFENE HCL;LY156758 hydrochloride;LY139481 hydrochloride;Latilavir secondary VI;Evista (Raloxifene HCl)
CBNumber: CB6302366
Molecular Formula: C28H28ClNO4S
Formula Weight: 510.04
MOL File: 82640-04-8.mol

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Raloxifene hydrochloride Property

Melting point:: 250-253°C
storage temp.: 2-8°C
solubility: DMSO: 28 mg/mL, soluble
form: solid
color: light yellow
λmax: 286nm(lit.)
Merck: 14,8098
BCS Class: 2
InChI: InChI=1S/C28H27NO4S.ClH/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29;/h4-13,18,30-31H,1-3,14-17H2;1H
InChIKey: BKXVVCILCIUCLG-UHFFFAOYSA-N
SMILES: C1(C(=O)C2C=CC(OCCN3CCCCC3)=CC=2)C2C=CC(O)=CC=2SC=1C1C=CC(O)=CC=1.Cl
CAS DataBase Reference: 82640-04-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25
WGK Germany: 3
RTECS: PC4956925
HS Code: 2934990002

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR1852
Product name: Raloxifene hydrochloride for peak identification
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 500mg
Price: $173
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1598201
Product name: Raloxifene hydrochloride
Packaging: 200mg
Price: $436
Updated: 2024/03/01

Cayman Chemical

Product number: 27189
Product name: Raloxifene (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $648
Updated: 2024/03/01

Cayman Chemical

Product number: 10011620
Product name: Raloxifene (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 10011620
Product name: Raloxifene (hydrochloride)
Purity: ≥98%
Packaging: 100mg
Price: $61
Updated: 2024/03/01

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Raloxifene hydrochloride Chemical Properties,Usage,Production

Description

Raloxifene was launched as Evista in the US for the prevention of postmenopausal osteoporosis. It is noteworthy that this molecule was formerly under development as keoxifene for breast cancer and prostatic hypertrophy. Raloxifene can be prepared by acylation of 6-methoxy-2-(4-methoxyphenyl) benzothiophene followed by simultaneous demethylation of both methoxy groups. Raloxifen is a selective estrogen receptor modulator, exerting antiestrogenic action on certain tissues (breast) and also estrogenic action on bone metabolism or serum lipids. In normal early postmenopausal women, 200 mg daily produced a trend towards suppression of estrogen effects. Raloxifen impeded bone loss in osteoporosis. A two-year study in postmenopausal women with an increased risk for osteoporosis showed that Raloxifen markedly prevented non-traumatic vertebral fractures. Results of several clinical studies demonstrated that Raloxifen appreciably reduced the risk of developing breast cancer. Moreover, it had favourable effect on lipid profiles without having the potential side-effects of estrogen-based therapies. Several extensions for different uses of this molecule are planned, for example growth disorder, obesity, colon tumor and skin atrophy. No serious drug-related events have been reported in the limited number of clinical trials.

Chemical Properties

Light-Yellow Solid

Originator

Lilly (US)

Uses

Raloxifene hydrochloride can be used as a nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic.

Uses

amino acid, nutrient. A nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic.Insoluble in water.

Uses

Labeled Raloxifene, intended for use as an internal standard for the quantification of Raloxifene by GC- or LC-mass spectrometry.

Definition

ChEBI: A hydrochloride salt resulting from the reaction of equimolar amounts of raloxifene and hydrogen chloride.

brand name

Evista (Lilly).

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biochem/physiol Actions

Raloxifene is a selective estrogen receptor modulator (SERM); acts as an anti-estrogen in both breast and uterine tissue while being estrogenic in bone. May have efficacy against estrogen-sensitive cancers.

Clinical Use

Treatment and prevention of osteoporosis in post menopausal women

Drug interactions

Potentially hazardous interactions with other drugs
Anticoagulants: antagonism of anticoagulant effect of coumarins.
Colestyramine: reduced absorption of raloxifene - avoid.

Metabolism

Raloxifene undergoes extensive first pass metabolism to the glucuronide conjugates: raloxifene-4'- glucuronide, raloxifene-6-glucuronide, and raloxifene-6, 4′-diglucuronide.
Raloxifene undergoes enterohepatic recycling, and is excreted almost entirely in the faeces. Less than 6% of dose is excreted in the urine.

storage

+4°C (desiccate)

References

[1] obach rs.potent inhibition of human liver aldehyde oxidase by raloxifene.

Raloxifene hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Raloxifene hydrochloride manufacturers

zhuzhou dingcheng meihei comestic co.,ltd

Product: Raloxifene Hydrochloride / Keoxifene / Evista 82640-04-8
Price: US $40.00/Box
Min. Order: 1Box
Purity: 99.99%
Supply Ability: 10000000000
Release date: 2023-12-06

Shanghai Getian Industrial Co., LTD

Product: Raloxifene hydrochloride 82640-04-8
Price: US $26.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 100000box
Release date: 2024-04-28

Hong Kong Excellence Biotechnology Co., Ltd.

Product: Raloxifene hcl 82640-04-8
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 20tons
Release date: 2023-10-12

82640-04-8, Raloxifene hydrochlorideRelated Search:

Diethoxymethyl acetate 2-Ethoxyphenol Benzo[b]thien-2-ylboronic acid Ethoxyquin Topotecan hydrochloride Phenetidine 1-AdaMantanethylaMine DIETHOXYMETHANE acetic acid, triethoxy-, ethyl ester CHLOROPHOSPHONAZO III Raloxifene 4-Ethoxyphenol Droloxifene Ranitidine hydrochloride Lercanidipine hydrochloride Clindamycin hydrochloride Tramadol hydrochloride Sibutramine hydrochloride

RALOXIFENE HCL

Raloxifene hydrochloride,Keoxifene hydrochloride, LY 156758, [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride

Raloxifene Hydrochloride (200 mg)

2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethoxy]phenyl}carbonyl)-1-benzothiophen-6-ol hydrochloride

(6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)Methanone hydrochloride

Evista(Raloxifene Hydrochloride

(6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)-(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanon

[6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone,hydrochloride (1:1)

LY156758 (Keoxifene) HCl

Evista (Raloxifene HCl)

Methanone,[6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-,hydrochloride (1:1)

(6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)-(4-(2-(piperidin-1-yl)ethoxy)phenyl)metha

6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl) ethoxy]phenyl]methanone HCl

Raloxifene Hydrochloride Tablets

LY156758 hydrochloride

CS-127

RALOXIFENE HYDROCHLORIDE

KEOXIFENE

KEOXIFENE HYDROCHLORIDE

LY 139481

AKOS 92138

ly156758

methanone,(6-hydroxy-2-(4-hydroxyphenyl)benzo(b)thien-3-yl)(4-(2-(1-piperidin

[6-HYDROXY-2-(4-HYDROXYPHENYL)BENZO[B]THIEN-3-YL][4-[2-(1-PIPERIDINYL)ETHOXY]PHENYL]-METHANONE HYDROCHLORIDE

[6-Hydroxy-2-(4-Hydroxyphenyl) benzo[b]thien-3-yl]

RALOXIFENEHYDROCHLORIDE(SUBJECTTOPATENTFREE)

Keoxifene hydrochloride, LY 156758, [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride

LY139481 hydrochloride

Raloxifene hydrochloride,>98%

[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone Hydrochloride

Raloxifene hydrochloride USP/EP/BP

Latilavir secondary VI

Raloxifene hydrochloride Evista

[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone

Raloxefene hydrochloride

Raloxifene HCl (LY-139481)

Raloxifene hydrochloride (Y0001134)

Raloxifene Hydrochloride (1598201)

(1aΞ,7aΞ)-1a-methyl-7a-[(2E,7RS,11RS)-3,7,11,15-tetramethylhexadec-2-en-1-yl]-1a,7a-dihydronaphtho[2,3-b]oxirene-2,7-dione (trans-epoxyphytomenadione isomers)

82640-04-8

28640-04-8

C28H27NO4S.HCl

C28H27NO4SClH

C28H27NO4SHClC28H28ClNO4S

API

Pharmaceutical intermediate

Inhibitors

antifungal

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds

Active Pharmaceutical Ingredients

Raloxifene

Intracellular receptor