Benzo[b]thien-2-ylboronic acid
Uses- Product Name
- Benzo[b]thien-2-ylboronic acid
- CAS No.
- 98437-23-1
- Chemical Name
- Benzo[b]thien-2-ylboronic acid
- Synonyms
- Benzo;BENZO[B]THIOPHEN-2-YLBORONIC ACID;2-BENZOTHIENYLBORONIC ACID;Benzothien-2-yl Boronic Acid;BENZOTHIOPHENE-2-BORONIC ACID;Benzo[b]thiophen-2-boronic acid;BENZO[B]THIOPHENE-2-BORONIC ACID;1-BENZOTHIOPHEN-2-YLBORONIC ACID;BZBTH2B;AKOS BRN-0028
- CBNumber
- CB5275458
- Molecular Formula
- C8H7BO2S
- Formula Weight
- 178.02
- MOL File
- 98437-23-1.mol
Benzo[b]thien-2-ylboronic acid Property
- Melting point:
- 254-256 °C
- Boiling point:
- 390.2±34.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- soluble in Tetrahydrofuran
- form
- Powder
- pka
- 6.99±0.30(Predicted)
- color
- White to off-white
- Water Solubility
- Insoluble in water.
- BRN
- 1637924
- InChI
- InChI=1S/C8H7BO2S/c10-9(11)8-5-6-3-1-2-4-7(6)12-8/h1-5,10-11H
- InChIKey
- YNCYPMUJDDXIRH-UHFFFAOYSA-N
- SMILES
- B(C1SC2=CC=CC=C2C=1)(O)O
- CAS DataBase Reference
- 98437-23-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 37/39-26-36
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 499978
- Product name
- Benzo[b]thien-2-ylboronic acid
- Purity
- ≥95%
- Packaging
- 5g
- Price
- $118.3
- Updated
- 2025/07/31
- Product number
- 499978
- Product name
- Benzo[b]thien-2-ylboronic acid
- Purity
- ≥95%
- Packaging
- 25g
- Price
- $609
- Updated
- 2025/07/31
- Product number
- B2893
- Product name
- Benzo[b]thiophene-2-boronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $26
- Updated
- 2025/07/31
- Product number
- B2893
- Product name
- Benzo[b]thiophene-2-boronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $79
- Updated
- 2025/07/31
- Product number
- B2893
- Product name
- Benzo[b]thiophene-2-boronic Acid (contains varying amounts of Anhydride)
- Packaging
- 25g
- Price
- $315
- Updated
- 2025/07/31
Benzo[b]thien-2-ylboronic acid Chemical Properties,Usage,Production
Uses
Thianaphthene-2-boronic Acid is used in the preparation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors.
Chemical Properties
white tooff-whitepowder
Uses
suzuki reaction
Uses
Thianaphthene-2-boronic Acid is used in the preparation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors.
Uses
Reactant involved in:
- PDE4 inhibitors
- Chemoselective modification of oncolytic adenovirus
- Synthesis of phosphorescent sensor for quantification of copper(II) ion
- UV promoted phenanthridine syntheses
- Preparation of CYP11B1 inhibitors for treatment of cortisol dependent diseases
- Suzuki-Miyaura cross-coupling reactions
Synthesis
121-43-7
95-15-8
98437-23-1
The general procedure for the synthesis of benzothiophene-2-boronic acid from trimethyl borate and benzothiophene was as follows: 144 g (554 mmol) of benzothiophene and 1,000 mL of tetrahydrofuran were added to a 2L reactor and mixed with stirring. After cooling the reaction mixture to -78 °C, 415 mL of n-butyllithium (1.6 M hexane solution) was slowly added dropwise and stirred for 1 hour at this temperature. Subsequently, the temperature of the reaction mixture was gradually brought to room temperature and kept stirring for 12 hours. After cooling again to -78 °C, 80.3 mL (664 mmol) of trimethyl borate was slowly added dropwise and stirred at room temperature for 2 hours. After completion of the reaction, the mixture was cooled to 0°C and acidified by adding 2N aqueous hydrochloric acid. Extraction was separated with ethyl acetate and distilled water and the organic layer was collected. The organic layer was concentrated under reduced pressure and filtered to give 86 g of the intermediate benzothiophene-2-boronic acid in 87.3% yield.
References
[1] Patent: KR2016/2328, 2016, A. Location in patent: Paragraph 0413-0415
Benzo[b]thien-2-ylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Benzo[b]thien-2-ylboronic acid manufacturers
- Product
- 1-Benzothiophen-2-ylboronic acid 98437-23-1
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-07-29
- Product
- Benzo[b]thien-2-ylboronic acid 98437-23-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-27
- Product
- Benzo[b]thien-2-ylboronic acid 98437-23-1
- Price
- US $35.00-25.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 Ton
- Release date
- 2023-10-27