Benzothiophene-3-boronic acid

Product Name: Benzothiophene-3-boronic acid
CAS No.: 113893-08-6
Chemical Name: Benzothiophene-3-boronic acid
Synonyms: AKOS BRN-0283;Benzo[b]thien-3-yL;ASDI-INTER 500027787;THIANAPHTHENE-3-BORONIC ACID;BENZOTHIOPHENE-3-BORONIC ACID;Thianaphthen-3-ylboronic acid;Benzo[b]thien-3-ylboronic acid;1-Benzothiophene-3-boronic Acid;Benzo[b]thiophen-3-ylboronicaci;Benzothiophene-3-ylboronic acid
CBNumber: CB4460512
Molecular Formula: C8H7BO2S
Formula Weight: 178.02
MOL File: 113893-08-6.mol

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Benzothiophene-3-boronic acid Property

Melting point:: 225-230 °C(lit.)
Boiling point:: 390.2±34.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
form: powder to crystal
pka: 8.29±0.30(Predicted)
color: White to Light yellow to Light orange
InChI: InChI=1S/C8H7BO2S/c10-9(11)7-5-12-8-4-2-1-3-6(7)8/h1-5,10-11H
InChIKey: QVANIYYVZZLQJP-UHFFFAOYSA-N
SMILES: B(C1=CSC2=CC=CC=C21)(O)O
CAS DataBase Reference: 113893-08-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 512117
Product name: Benzo[b]thien-3-ylboronic acid
Purity: ≥95.0%
Packaging: 5g
Price: $76.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 512117
Product name: Benzo[b]thien-3-ylboronic acid
Purity: ≥95.0%
Packaging: 25g
Price: $420
Updated: 2023/06/20

TCI Chemical

Product number: B4774
Product name: Benzo[b]thiophene-3-boronic Acid (contains varying amounts of Anhydride)
Packaging: 1g
Price: $47
Updated: 2025/07/31

TCI Chemical

Product number: B4774
Product name: Benzo[b]thiophene-3-boronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $142
Updated: 2025/07/31

Usbiological

Product number: 264555
Product name: Benzo[b]thiophene-3-boronic acid
Packaging: 250mg
Price: $336
Updated: 2021/12/16

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Benzothiophene-3-boronic acid Chemical Properties,Usage,Production

Uses

Benzo[b]thien-3-ylboronic acid can be used:

To prepare thienyl substituted?pyrimidine derivatives as potent antimycobacterial?compounds.
To prepare 3-O-protected 17-heteroaryl-3-hydroxyestra-1,3,5,16-tetraene-16-carbaldehyde, which in turn is used for the synthesis of heteroarenes-annelated estranes.
As a substrate in the study of metal-free coupling reactions of allylic alcohols with heteroaryl boronic acids.
As a starting material for the preparation of thienyl based quinoline and pyridine ligands, which are further used to synthesize platinum complexes.

Synthesis

7342-82-7

5419-55-6

113893-08-6

Under nitrogen protection, 10 g (47 mmol) of 3-bromobenzothiophene was dissolved in 100 ml of tetrahydrofuran (THF) and cooled to -60 °C. 36 ml of hexane solution of n-butyllithium (concentration 1.57 mol/L) was slowly added dropwise, and after the dropwise addition, the reaction mixture was continued to be stirred for 1 hour. Subsequently, 13.3 g (71 mmol) of triisopropyl borate was added and stirring was continued for 1 hour. The reaction system was slowly brought back to room temperature and the reaction was quenched by the addition of 50 ml of saturated aqueous ammonium chloride solution. The reaction mixture was extracted with 100 ml of toluene, the organic phase was washed three times (100 ml each) with distilled water and dried over anhydrous magnesium sulfate. The desiccant was removed by filtration and the solvent was removed by concentration under reduced pressure to afford intermediate B-1. 6.9 g (39 mmol, 83% yield) of the target product, benzothiophene-3-boronic acid, was finally obtained.

References

[1] Patent: EP2617724, 2013, A1. Location in patent: Paragraph 0162; 0163
[2] Patent: EP2628743, 2013, A1. Location in patent: Paragraph 0175

Benzothiophene-3-boronic acid Preparation Products And Raw materials

Raw materials

Thianaphthene Hexane N-Bromosuccinimide Cyclohexane Sodium thiosulfate Chloroform Tetrahydrofuran Diethyl ether Hydrochloric acid Bromine Triisopropyl borate Acetic acid Sodium hydroxide Magnesium sulfate n-Butyllithium Sodium carbonate

Preparation Products

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Benzothiophene-3-boronic acid Suppliers

Americas 1 Belgium 3 China 166 Europe 1 France 3 Germany 9 India 3 Italy 1 Japan 1 Russia 1 Switzerland 2 The Netherlands 1 United Kingdom 8 United States 48 Global 248

Shanghai Changyan Chem & Tech Co., Ltd.

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Sinopharm Chemical Reagent Co,Ltd.

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View Lastest Price from Benzothiophene-3-boronic acid manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Benzothiophene-3-boronic acid 113893-08-6
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-13

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Benzothiophene-3-boronic acid 113893-08-6
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-12

Hebei Yanxi Chemical Co., Ltd.

Product: Benzo[b]thiophen-3-ylboronic acid 113893-08-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 100kg
Release date: 2023-09-22

113893-08-6, Benzothiophene-3-boronic acidRelated Search:

Thianaphthene Dibenzothiophene Thifensulfuron methyl Cephalothin sodium Hyaluronic acid 5-CHLOROBENZOTHIOPHENE Phenylboronic acid Tetrahydrothiophene 2-Thiopheneboronic acid Folic acid Benzo[b]thien-2-ylboronic acid Thiophene Ethyl 2-(Chlorosulfonyl)acetate Benzofuran-2-boronic acid Citric acid Ascoric Acid N-Boc-indole-2-boronic acid 4-DIBENZOTHIOPHENEBORONIC ACID

AKOS BRN-0283

1-BENZOTHIOPHEN-3-YLBORONIC ACID

BENZO[B]THIOPHENE-3-BORONIC ACID

BENZOTHIOPHENE-3-BORONIC ACID

ASDI-INTER 500027787

THIANAPHTHENE-3-BORONIC ACID

Benzo[b]thiophen-3-yl-boronic acid

1-Benzothiophen-3-ylboronic acid ,97%

1-Benzothiophen-3-ylboronic acid, May contain varying amounts of anhydride, 97%

Benzo[b]thien-3-ylboronic acid

1-benzothien-3-ylboronic acid(SALTDATA: FREE)

1-Benzo[b]thiophen-3-ylboronic acid

3-Boronobenzo[b]thiophene, 1-Benzothiophene-3-boronic acid, 3-Borono-1-benzothiophene, Thianaphthene-3-boronic acid

Benzo[b]thiophene-3-boronic acid 95+%

1-Benzothiophene-3-boronic Acid

Benzothiophene-3-boronic acid Thianaphthene-3-boronic acid

Thianaphthen-3-ylboronic acid

Benzo[b]thien-3-ylboronic acid >=95.0%

Benzo[b]thiophene-3-boronic Acid (contains varying amounts of Anhydride)

Boronic acid,B-benzo[b]thien-3-yl-

B-Benzo[b]thien-3-ylboronic acid

Benzo[b]thiophene-3-boronic acid, 97%, contains varying amounts of anhydride

Benzo[b]thiophene-3-boronic Acid (contains varying amounts of Anhydride) &gt

Benzo[b]thien-3-yL

Benzo[b]thiophen-3-ylboronicaci

Benzothiophene-3-ylboronic acid

benzo[b]thiophen-3-ylboronicacid(containsvaryingamountsofAnhydride)

Benzo[<i>b</i>]thien-3-ylboronic acid

113893-08-6

113893-08-06

BORONIC ACID

Heteroaryl

Organometallic Reagents

Boronic Acids and Derivatives

Boronic Acids

Boronic Acids and Derivatives

Chemical Synthesis

Heteroaryl Boronic Acids

Organometallic Reagents

blocks

BoronicAcids

Boronic Acids

Boronic Acids and Derivatives

Heteroaryl