arglabin
- Product Name
- arglabin
- CAS No.
- 84692-91-1
- Chemical Name
- arglabin
- Synonyms
- CS-1320;arglabin;Arglabine;Arglabin, BR;(+)-Arglabin;Arglabin 84692-91-1;Arglabin ((+)-Arglabin);(3aS)-2,3,3aβ,4,5β,6,6a,7,9aβ,9bα-Decahydro-6α,6aα-epoxy-6,9-dimethyl-3-methyleneazuleno[4,5-b]furan-2-one;(3aR,4aS)-1,4aα-Dimethyl-7-methylene-4a,5,6,6aα,9aβ,9bα-hexahydro-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(7H)-one;(3aR,4aS,6aS,9aS,9bR)-5,6,6a,7,9a,9b-Hexahydro-1,4a-dimethyl-7-methylene-3H-oxireno[8,8a]azuleno[4,5-b]furan-8(4aH)-one
- CBNumber
- CB01355299
- Molecular Formula
- C15H18O3
- Formula Weight
- 246.3
- MOL File
- 84692-91-1.mol
arglabin Property
- Melting point:
- 100-102 °C
- Boiling point:
- 404.6±45.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- Amber Vial, -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly)
- form
- Solid
- color
- Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1570
- Product name
- Arglabin
- Purity
- ≥98% (HPLC)
- Packaging
- 1MG
- Price
- $108
- Updated
- 2024/03/01
- Product number
- SML1570
- Product name
- Arglabin
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $435
- Updated
- 2024/03/01
- Product number
- 19502
- Product name
- Arglabin
- Packaging
- 500μg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 19502
- Product name
- Arglabin
- Packaging
- 1mg
- Price
- $92
- Updated
- 2024/03/01
- Product number
- 19502
- Product name
- Arglabin
- Packaging
- 5mg
- Price
- $380
- Updated
- 2024/03/01
arglabin Chemical Properties,Usage,Production
Description
Arglabin is a new antineoplastic agent launched in Russia for the treatment of a variety of cancers. It is a sesquiterpene gamma-lactone extracted from Artemisia glabella, a plant from Kazakstan; it was first developed in Kazakstan followed by US and other countries as an ethical pharmaceutical. Arglabin can be obtained by resin extraction from A.glabella, purification by chromatography and finally recrystallization. Arglabin is a potent and selective inhibitor of farnesyl transferase, an enzyme critical to the function of the Ras oncogene in cancer cell reproduction. It showed a strong Inhibitory effect against tumor cells proliferation in in vitro models of transformed mouse hepatocytes and splenocytes. This cytotoxic effect against tumor cells was 50-100 times higher than that on intact cells. In many patients with various cancers, Arglabin was shown to stop or inhibit the tumour development, alone or in combination with other anticancer agents, and was reportedly well tolerated with few sideeffects. Promising response rates were also reported with Arglabin after treating other 《difficult-to-treat cancers》 such as breast, ovarian, lung or colon cancers.
Originator
NuOncology Labs (Kazakstan)
Uses
Arglabin is a sesquiterpene lactone used in the inhibition of glucose induced NF-kB activation and MCP-1/TGF-β1 expression treating diabetic nephropathy. Cytocoxic.
Definition
ChEBI: An organic heterotetracyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-dimethyl-1,3a,4,5,6,7-hexahydroazulen-5-yl group in which the double bond in the 7-membered ring has been epoxidised and in which the hydroxy group and the carboxy group have undergone formal condensation to give the corresponding gamma-lactone. It is found in Artemisia glabella. Arglabin-DMA HCl, the hydrochloride salt of the add ct resulting from the conjugate addition of dimethylamine to the ene-lactone moiety, has been successfully used in Khazakhstan for the treatment of breast, colon, ovarian and lung cancers.
storage
Room temperature
arglabin Preparation Products And Raw materials
Raw materials
Preparation Products
arglabin Suppliers
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2922
- Advantage
- 55
- Tel
- 0871-65217109 13211707573;
- Fax
- 0871-65215563
- y.liu@mail.biobiopha.com
- Country
- China
- ProdList
- 5653
- Advantage
- 65
- Tel
- +86-028-82633397 18982077548
- Fax
- +86-28-82633165
- cwb1@biopurify.cn
- Country
- China
- ProdList
- 2376
- Advantage
- 60
- Tel
- 400-186-5138 13341702378
- Fax
- QQ：190129269
- winherb@126.com
- Country
- China
- ProdList
- 1009
- Advantage
- 58
- Tel
- 025-84430028 13815430202
- sale02@cqherb.com
- Country
- China
- ProdList
- 282
- Advantage
- 59
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
- Tel
- 021-51320588
- Fax
- 0086-21-51320502
- tauto@tautobiotech.com
- Country
- China
- ProdList
- 3989
- Advantage
- 66
- Tel
- 027-59599241 18871490274
- Fax
- 027-59599241
- 1400878000@qq.com
- Country
- China
- ProdList
- 9958
- Advantage
- 58
- Tel
- 18607101326 15172504745
- Fax
- +86-27-84254680
- aileen@chemfaces.com
- Country
- China
- ProdList
- 6905
- Advantage
- 55
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9248
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9806
- Advantage
- 58
- Tel
- 020-61288194 61288195
- Fax
- 020-61288700
- 505721671@qq.com
- Country
- China
- ProdList
- 3866
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 27313
- Advantage
- 60
- Tel
- 4009903999 13395398332
- Fax
- 0539-6365991
- sales@xiyashiji.com
- Country
- China
- ProdList
- 20806
- Advantage
- 60
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29785
- Advantage
- 68
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58
- Tel
- 17721395025
- Fax
- 021-68882955
- 2423903095@qq.com
- Country
- China
- ProdList
- 4088
- Advantage
- 58
- Tel
- 021-36031160 13311776681
- 3338195766@QQ.com
- Country
- China
- ProdList
- 5175
- Advantage
- 55
- Tel
- 021-69955236-807 13918189704
- Fax
- 021-65211385
- chinaruji@chinaruji.com
- Country
- China
- ProdList
- 5176
- Advantage
- 55
- Tel
- 028-88203606; 18283602253
- jancyzheng@gcgreenpure.com
- Country
- China
- ProdList
- 1589
- Advantage
- 58
- Tel
- 021-021-57127007-6622-6622 17621252073
- Fax
- +86 (21) 5132-0077
- luzh@nature-standard.com
- Country
- China
- ProdList
- 3021
- Advantage
- 58
- Tel
- 86-21-50801717-301
- Fax
- 86-21-50800509
- wangjh@sirc-tcm.sh.cn
- Country
- China
- ProdList
- 2070
- Advantage
- 58
- Tel
- 400-638-7771 18920564737
- sales@heowns.com
- Country
- China
- ProdList
- 22961
- Advantage
- 60
- Tel
- 021-58958002 18930822973
- Fax
- 021-58958618
- sales@uhnshanghai.com
- Country
- China
- ProdList
- 1942
- Advantage
- 58
- Tel
- 0371-0371-55051623 18137891487
- Fax
- QQ：2853979817
- 2853979817@qq.com
- Country
- China
- ProdList
- 9933
- Advantage
- 58
- Tel
- 025-025-51191215 18013836722
- Fax
- 025-51191215
- 2399235533@qq.com
- Country
- China
- ProdList
- 4933
- Advantage
- 58
- Tel
- Country
- China
- ProdList
- 11415
- Advantage
- 58
- Tel
- +8615255079626
- eric@witopchemical.com
- Country
- China
- ProdList
- 23541
- Advantage
- 58
- Tel
- +1-2135480471 +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
- Tel
- +86-13806087780
- sale@simagchem.com
- Country
- China
- ProdList
- 17365
- Advantage
- 58
- Tel
- 0531-69900633 18340090523
- changyuan20@163.com
- Country
- China
- ProdList
- 2649
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9409
- Advantage
- 58
- Tel
- 028-81700200 18108052721
- 2850505130@qq.com
- Country
- China
- ProdList
- 5176
- Advantage
- 58
- Tel
- +86-023-6139-8061 +86-86-13650506873
- sales@chemdad.com
- Country
- China
- ProdList
- 39894
- Advantage
- 58
- Tel
- 028-028-85142057 19983342022
- Fax
- 028-85142057
- 3005359975@qq.com
- Country
- China
- ProdList
- 1956
- Advantage
- 58
- Tel
- 15927387915 15337108568
- 2769903731@qq.com
- Country
- China
- ProdList
- 3336
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- 021-38015121 15000105423
- wulan@absin.cn
- Country
- China
- ProdList
- 24731
- Advantage
- 58
- Tel
- 021-51111890 15317326293
- sales@molnova.com
- Country
- China
- ProdList
- 4195
- Advantage
- 58
- Tel
- 021-57810052 18930344717
- Fax
- 021-57810052
- 2089316240@qq.com
- Country
- China
- ProdList
- 9395
- Advantage
- 58
- Tel
- 021-57763112 13585886131
- 3004987436@qq.com
- Country
- China
- ProdList
- 9693
- Advantage
- 58
- Tel
- 021-57886085 17317861055
- shhebio@126.com
- Country
- CHINA
- ProdList
- 7974
- Advantage
- 58
- Tel
- 0571-89903882 13626641628
- jiangnan@huidabiotech.com
- Country
- China
- ProdList
- 3656
- Advantage
- 58
- Tel
- 029-84385017-8003 13259417953
- Fax
- QQ1477918929
- sales@pioneerbiotech.com
- Country
- China
- ProdList
- 425
- Advantage
- 58
- Tel
- 0519-85524369
- 3477467573@qq.com
- Country
- China
- ProdList
- 8617
- Advantage
- 58
- Tel
- 027-59223108 15972152991
- Fax
- 027-59223108
- 1248580099@qq.com
- Country
- China
- ProdList
- 9988
- Advantage
- 58
- Tel
- 027-59308705 18871579363
- Fax
- 027-59308705
- 1248680011@qq.com
- Country
- China
- ProdList
- 9950
- Advantage
- 58
- Tel
- 027-59223025 15107168801
- Fax
- 027-59223025
- 1718480011@qq.com
- Country
- China
- ProdList
- 9850
- Advantage
- 58
- Tel
- 027-59106051 13627137652
- Fax
- 027-59223020
- 1438180055@qq.com
- Country
- China
- ProdList
- 9963
- Advantage
- 58
View Lastest Price from arglabin manufacturers
- Product
- Arglabin 84692-91-1 84692-91-1
- Price
- US $130.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%
- Supply Ability
- 1000.00 kgs
- Release date
- 2019-07-09
- Product
- arglabin 84692-91-1
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23