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VERATRIDINE

Product Name
VERATRIDINE
CAS No.
71-62-5
Chemical Name
VERATRIDINE
Synonyms
NSC 7524;ybenzoate);Veratrdine;VERATRIDINE;,4alpha,16beta)-;Veratridine, >=98%;veratrine(amorphous);VERATRIDINE FREE BASE;3-VERATROYLVERACEVINE;Veracevine, veratrate
CBNumber
CB1156432
Molecular Formula
C36H51NO11
Formula Weight
673.79
MOL File
71-62-5.mol
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VERATRIDINE Property

Melting point:
180℃
alpha 
D20 +8.0° (ethanol)
Boiling point:
689.74°C (rough estimate)
Density 
1.45±0.1 g/cm3 (20 ºC 760 Torr)
refractive index 
1.6630 (estimate)
storage temp. 
-20°C
solubility 
ethanol: 50 mg/mL
pka
9.54(at 25℃)
form 
powder
color 
white to off-white
Merck 
13,10016
BRN 
78875
CAS DataBase Reference
71-62-5
EPA Substance Registry System
Veratridine (71-62-5)
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Safety

Hazard Codes 
T+
Risk Statements 
26/27/28-36/37/38-62-52/53-48/20
Safety Statements 
26-36/37/39-45-61-36/37-28
RIDADR 
UN 1544 6.1/PG 1
WGK Germany 
2
RTECS 
YX5600000
10
HazardClass 
6.1(a)
PackingGroup 
II
Hazardous Substances Data
71-62-5(Hazardous Substances Data)
Toxicity
LD50 in mice (mg/kg): 1.35 i.p. (Swiss, Bauer); 0.42 i.v. (Krayer); 6.3 s.c. (Tanaka)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H310Fatal in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H330Fatal if inhaled

H335May cause respiratory irritation

H361Suspected of damaging fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P320Specific treatment is urgent (see … on this label).

P330Rinse mouth.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
676950-M
Product name
Veratridine
Purity
A Na
Packaging
5mg-m
Price
$89.3
Updated
2021/12/16
Sigma-Aldrich
Product number
676950-M
Product name
Veratridine - CAS 71-62-5 - Calbiochem
Purity
A Na+ channel opener.
Packaging
5 mg
Price
$89.3
Updated
2021/12/16
Sigma-Aldrich
Product number
V5754
Product name
Veratridine
Purity
≥90% (HPLC), powder
Packaging
10mg
Price
$202
Updated
2021/12/16
Sigma-Aldrich
Product number
V5754
Product name
Veratridine
Purity
≥90% (HPLC), powder
Packaging
25mg
Price
$393
Updated
2021/03/22
Sigma-Aldrich
Product number
V5754
Product name
Veratridine
Purity
≥90% (HPLC), powder
Packaging
100mg
Price
$1200
Updated
2021/03/22
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VERATRIDINE Chemical Properties,Usage,Production

Description

This steroidal alkaloid from Veratrum viride was given this name by Bosetti. It is almost certainly identical with the amorphous veratrine isolated by Schmidt and Koppen, Merck, and Wright and Luff. The base is a colourless, amorphous powder which melts over a wide range. It has [α]22D + 8.0° (EtOH) and yields a sulphate nonahydrate which forms colourless silky needles that resinify in air. The nitrate is only sparingly soluble in H2O. The solution of the alkaloid in H2SO4 becomes orange-red and eventually crimson with a blue fluorescence while that in HCI is colourless. Alkaline hydrolysis furnishes veratric acid and cevine.

Uses

Veratridine causes Na+ channels to stay open during a sustained membrane depolarization by abolishing inactivation.?This, in turn, opens voltage-activated calcium channels, thus increasing intracellular calcium content and inducing neurotransmitter release. Alkaloid neurotoxin which depolarizes excitable tissue; used to increase membrane sodium permeability.

General Description

Veratridine is one of several alkaloids isolated from the seeds of Schoenocaulon officinale and from the rhizome of Veratrum album. The crude extract is called veratrine or sabadilla and contains cevadine, veratridine, cevadilline, sabadine and cevine. It is a neurotoxin, which belongs to the family Liliaceae and genus, Schoenocaulon. Veratridine is soluble in lipid.

Biochem/physiol Actions

Opens voltage-dependent Na+ channels and prevents their inactivation. This, in turn, opens voltage-activated calcium channels, thus increasing intracellular calcium content and inducing neurotransmitter release. Alkaloid neurotoxin which depolarizes excitable tissue; used to increase membrane sodium permeability. Veratridine is cytotoxic to chromaffin cells in vitro.

Purification Methods

It is an alkaloid neurotoxin which prevents inactivation of Na+ channels. Its solubility in EtOH is ~5%; and it separates as a pale yellow powder from an ethanolic solution on addition of Et2O. It forms nitrate, sulfate and perchlorate salts. [McKinney et al. Anal Biochem 153 33 1986, Beilstein 21 V/13 709.]

References

Merck., Annalen, 95, 200 (1855)
Schmidt, Koppen., Ber., 9, 1115 (1876)
Wright, Luff.,J. Chem. Soc., 35, 421 (1879)
Bosetti., Arch. Pharm., 221,82 (1883)
Blount., Chem. Zeit., 26,334 (1902)

VERATRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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VERATRIDINE Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
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Chembest Research Laboratories Limited
Tel
021-20908456-
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
5947
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Ascent Scientific
Tel
4401179829988
Fax
4402030 700 369
Email
customerservice@ascentscientific.co.uk
Country
United Kingdom
ProdList
279
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Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
4041
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Shanghai TaoShu Biochemical Technology Co., Ltd.
Tel
021-33632979-
Fax
021-33632979
Email
service1@targetmol.com
Country
China
ProdList
7962
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ChemStrong Scientific Co.,Ltd
Tel
0755-66853366-
Email
sales@chem-strong.com
Country
China
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26481
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Sigma-Aldrich
Tel
021-61415566- ;
Email
orderCN@merckgroup.com;orderCN@merckgroup.com
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China
ProdList
50837
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Alta Scientific Co., Ltd.
Tel
022-65378550- ;022-65378550-
Fax
022-2532-9655
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sales@altascientific.com;marketing@altascientific.com
Country
China
ProdList
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Zhengzhou KeYulong chemical products Co., Ltd
Tel
Fax
0371-53335504
Email
keyulongchem@163.com
Country
China
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EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8454
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71-62-5, VERATRIDINERelated Search:


  • 3-VERATROYLVERACEVINE
  • VERATRIDINE
  • ,4alpha,16beta)-
  • 4,9-epoxycevane-3,4,12,14,16,17,20-heptol3-(3,4-dimethoxybenzoate)
  • cevane-3,4,12,14,16,17,20-heptol,4,9-epoxy-,3-(3,4-dimethoxybenzoate),(3beta
  • Veratridine - CAS 71-62-5 - Calbiochem
  • cevane-3-beta,4-alpha,12,14,16-beta,17,20-heptol,4,9-epoxy-,3-(3,4-dimethox
  • veratrine(amorphous)
  • ybenzoate)
  • 4,9-epoxycevane-3beta,4alpha,12,14,16beta,17,20-heptol 3-veratrate
  • VERATRIDINE FREE BASE
  • 4α,9-Epoxy-3β-veratroyloxy-5β-cevan-4β,12,14,16β,17,20-hexaol
  • NSC 7524
  • Veracevine, veratrate
  • Veratridine, >=98%
  • Veratrdine
  • O3-(3,4-Dimethoxybenzoyl)veracevine
  • 1,2,4-triazolo[4,3-a]pyridin-3-ol
  • Cevane-3,4,12,14,16,17,20-heptol, 4,9-epoxy-, 3-(3,4-dimethoxybenzoate), (3β,4α,16β)-
  • 71-62-5
  • C36H51NO11
  • C36H51O11
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Monovalent Ion Channels
  • Other Sodium Channel Modulators
  • Ion Channels
  • Voltage-gated Ion Channels
  • Sodium Channel Modulators
  • Ion Channels
  • Alkaloids