3-(1-METHYL-PIPERIDIN-4-YL)-PROPAN-1-OL
- Product Name
- 3-(1-METHYL-PIPERIDIN-4-YL)-PROPAN-1-OL
- CAS No.
- 7037-30-1
- Chemical Name
- 3-(1-METHYL-PIPERIDIN-4-YL)-PROPAN-1-OL
- Synonyms
- 1-METHYL-4-PIPERIDINEPROPANOL;4-N-Methyl piperidine propanol;4-Piperidinepropanol, 1-methyl-;3-(1-methyl-4-piperidyl)propan-1-ol;4-(3-Hydroxypropyl)-1-methylpiperidine;3-(1-methyl-4-piperidyl)propan-1-ol - [M87281]
- CBNumber
- CB21010183
- Molecular Formula
- C9H19NO
- Formula Weight
- 157.25
- MOL File
- 7037-30-1.mol
3-(1-METHYL-PIPERIDIN-4-YL)-PROPAN-1-OL Property
- Boiling point:
- 114-116 °C(Press: 4 Torr)
- Density
- 0.929±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 15.16±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CHM0009592
- Product name
- 3-(1-METHYL-PIPERIDIN-4-YL)-PROPAN-1-OL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.49
- Updated
- 2021/12/16
- Product number
- CM116546
- Product name
- 4-(3-Hydroxypropyl)-1-methylpiperidine
- Purity
- 95%
- Packaging
- 5g
- Price
- $673
- Updated
- 2021/12/16
- Product number
- CM116546
- Product name
- 4-(3-Hydroxypropyl)-1-methylpiperidine
- Purity
- 95%
- Packaging
- 10g
- Price
- $1075
- Updated
- 2021/12/16
- Product number
- 7037301
- Product name
- 3-(1-Methylpiperidin-4-yl)propan-1-ol
- Packaging
- 10g
- Price
- $1184.5
- Updated
- 2021/12/16
- Product number
- 61-10081
- Product name
- 3-(1-Methylpiperidin-4-yl)propan-1-ol
- Purity
- 95-98%
- Packaging
- 5g
- Price
- $1215
- Updated
- 2021/12/16
3-(1-METHYL-PIPERIDIN-4-YL)-PROPAN-1-OL Chemical Properties,Usage,Production
Synthesis
154775-43-6
7037-30-1
General procedure for the synthesis of 3-(1-methylpiperidin-4-yl)-1-propanol from 1-N-BOC-4-piperidinepropionic acid: A. Synthesis of 3-(1-methylpiperidin-4-yl)-propan-1-ol. To a tetrahydrofuran (THF) solution (40 mmol) of 1N lithium aluminum hydride, a THF solution (30 mL) of N-BOC-4-piperidinepropionic acid (3.0 g, 11.6 mmol) was added slowly and dropwise under reflux conditions. The reaction mixture was heated to reflux for 3 hours and then cooled to room temperature. The mixture was further cooled to 0 °C, water (1.5 mL) was slowly added and the reaction mixture was warmed to room temperature within 15 minutes. The mixture was again cooled to 0°C and 10% sodium hydroxide solution (1.5 mL) was slowly added. After warming to room temperature within 15 minutes, the mixture was again cooled to 0°C and additional water (4.5 mL) was added. The resulting mixture was slowly warmed to room temperature over 18 hours and subsequently filtered through a diatomaceous earth pad. The filtrate was concentrated under reduced pressure and the residue was purified by method 2 to give 1.9 g (100% yield) of 3-(1-methylpiperidin-4-yl)-propan-1-ol as a yellow oil. Mass spectrum (electrospray): calculated mass of C9H19NO, 157.15; measured value: 157.15. m/z found, 158.1 [M+H]+. 1H NMR (400MHz, CD3OD): δ 3.45-3.41(m, 2H), 2.77-2.74(m, 2H), 1.89-1.85(m, 2H), 1.64 -1.61(m, 2H), 1.47-1.43(m, 2H), 1.21-1.12(m, 5H).
References
[1] Patent: US2005/70550, 2005, A1. Location in patent: Page/Page column 16-17
[2] Patent: US2005/261309, 2005, A1. Location in patent: Page/Page column 17
3-(1-METHYL-PIPERIDIN-4-YL)-PROPAN-1-OL Preparation Products And Raw materials
Raw materials
Preparation Products
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