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Deserpidine

Product Name
Deserpidine
CAS No.
131-01-1
Chemical Name
Deserpidine
Synonyms
Harmonyl;Raunormine;Canescine;Reserpidine;Recanescine;DESERPIDINE;Reserpine Impurity 3;Deserpidine USP/EP/BP;Deserpidine Solution, 100ppm;methyl 17-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylate
CBNumber
CB0834483
Molecular Formula
C32H38N2O8
Formula Weight
578.65
MOL File
131-01-1.mol
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Deserpidine Property

Melting point:
228-232°; mp 230-232°; mp 138° and 226-232° with resolidification at 175°
alpha 
D20 -163° (c = 0.5 in pyridine)
Boiling point:
638.28°C (rough estimate)
Density 
1.2277 (rough estimate)
refractive index 
1.6260 (estimate)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
6.68 in 40% methanol
form 
Solid
color 
White to Off-White
CAS DataBase Reference
131-01-1(CAS DataBase Reference)
NIST Chemistry Reference
Deserpidine(131-01-1)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
D289420
Product name
Deserpidine
Packaging
1mg
Price
$70
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PXT0000259
Product name
DESERPIDINE
Purity
95.00%
Packaging
1MG
Price
$616.08
Updated
2021/12/16
Matrix Scientific
Product number
094177
Product name
Deserpidine
Purity
95+%
Packaging
250mg
Price
$742
Updated
2021/12/16
Matrix Scientific
Product number
094177
Product name
Deserpidine
Purity
95+%
Packaging
1g
Price
$1647
Updated
2021/12/16
AvaChem
Product number
3055
Product name
Deserpidine
Packaging
10mg
Price
$79
Updated
2021/12/16
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Deserpidine Chemical Properties,Usage,Production

Chemical Properties

Crystalline solid; exists in three crystallineforms; mp 228–232°C (442.4–449.6°F); soluble in chloroform and methanol, insolublein water; pK 6.68 in saturated solution of40% methanol in water.

Originator

Harmonyl,Abbott,US,1957

Uses

Deserpidine, is an antihypertensive drug related to Reserpine (R144600). It is naturally found in Rauvolfia spp.

Uses

Deserpidine is found and extracted fromthe roots of Rauwolfia canescens L., andApocyanaceae. Therapeutically, it is used asan antihypertensive agent.

Definition

ChEBI: Deserpidine is an alkaloid ester, a methyl ester, a benzoate ester, an organic heteropentacyclic compound and a yohimban alkaloid. It derives from a hydride of a yohimban.

Manufacturing Process

500 parts by weight of dried, finely ground roots of Rauwolfia canescens are extracted batchwise with methanol at its boiling point, using the following volumes and times, and filtering each extract while hot: 2,000 parts by volume, 1 hour; 1,000 parts by volume, 45 minutes; 1,000 parts by volume, 30 minutes; 1,000 parts by volume, 30 minutes. The extracts are combined and evaporated in vacuo to 75 parts by volume of a thick syrupy solution.
After the addition of 75 parts by volume of methanol and 150 parts by volume of acetic acid of 15% strength with adequate mixing, the solution is extracted with 2 portions each of 100 parts by volume of hexane. The combined hexane extracts are extracted with 15 parts by volume of acetic acid of 15% strength. The latter extract is added to the above acetic acid phase which is then extracted with 3 portions each of 75 parts by volume and 1 portion of 50 parts by volume of ethylene chloride.
The first three extracts are combined and washed with 60 parts by volume of 2 N sodium carbonate solution and then with 60 parts by volume of distilled water. These washing solutions are saved and used for the washing of the 4th and final ethylene chloride extract. The combined ethylene chloride extracts are dried over sodium sulfate, filtered and evaporated in vacuo to a constant weight of a tan, frothy solid. One part by weight of this residue is dissolved in 1.5 parts by volume of warm methanol and the solution cooled to 5°C for 18 hours, whereby crystallization of a mixture containing principally reserpine sets in. After filtering this mixture and washing it with cool methanol, the filtrate is freed of solvent in vacuo.
Two parts by weight of the resulting red-brown solid froth are triturated with 2 portions each of 25 parts by volume of benzene and filtered each time. The benzene insoluble material is saved for further treatment. The benzene soluble fraction is poured on to a column of 40 parts by weight of activated alumina (Woelm, Activity Grade I) which is then eluted first with 3 portions each of 50 parts by volume of benzene and then with 6 portions each of 50 parts by volume of benzene-acetone (9:1), the first of which benzene-acetone portions had been used for extraction of the abovementioned benzene insoluble material. The second of the 6 benzene-acetone elution fractions on removal of the solvents gives a light tan solid froth which on crystallization from methanol gives colorless prismatic needles of slightly impure deserpidine. Rechromatographing of 1 part by weight of this substance on 20 parts by weight of activated alumina (Woelm, Activity Grade I) using benzene and benzene containing 0.1% methanol as eluting agents followed by crystallization from methanol gives colorless prismatic needles of pure deserpidine, melting at 228-232°C. Deserpidine obtained according to this example can be made up into pharmaceutical preparations.

brand name

Harmonyl(Abbott).

Therapeutic Function

Antihypertensive

Health Hazard

The pharmacological properties of deserpi dine are similar to those of reserpine, causingsedation and tranquilization. Toxic effectsfrom high doses include drowsiness, depres sion, nausea, diarrhea, abdominal cramps,and hypotension. It is less toxic than reserpine. However, the poisoning effects may begreater than those of other Rauwolfia alka loids, such as rescinnamine. An oral LD50value in mice is 500 mg/kg.There is some evidence of its carcinogenic actions in animals and humans. Ratsgiven oral doses of 54 mg/kg over 77 weeksdeveloped blood tumor. In humans, it mayproduce tumors in skin and appendages.Cancer-causing properties of deserpidine,however, are not yet fully established.

Deserpidine Preparation Products And Raw materials

Raw materials

Preparation Products

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Deserpidine Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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69
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8844
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52
Shanghai Meishui Chemical Technology Co., Ltd
Tel
021-60549325 18616193163
Fax
021-33250306
Country
China
ProdList
4526
Advantage
56
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18044
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Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ:800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
Shanghai Jovan Biochemical Technology Co. Ltd.
Tel
+86-021-61654350
Fax
+86-021-61654350
Email
1245958370@qq.com
Country
China
ProdList
2982
Advantage
50
Alta Scientific Co., Ltd.
Tel
022-6537-8550 15522853686
Fax
022-2532-9655
Email
sales@altasci.com.cn
Country
China
ProdList
4511
Advantage
55
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View Lastest Price from Deserpidine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Deserpidine 131-01-1
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Shaanxi Dideu Medichem Co. Ltd
Product
Deserpidine 131-01-1
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-09

131-01-1, DeserpidineRelated Search:


  • methyl 17-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylate
  • DESERPIDINE
  • Canescine
  • Harmonyl
  • Raunormine
  • Recanescine
  • Reserpidine
  • (1S,2R,3R,4aS,13bR,14aS)-2-methoxy-3-(3,4,5-trimethoxybenzoyl)oxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroisoquinolino[3,2-a]$b-carboline-1-carboxylic acid methyl ester
  • (1S,2R,3R,4aS,13bR,14aS)-Methyl 2-Methoxy-3-((3,4,5-triMethoxybenzoyl)oxy)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylate
  • Reserpine Impurity 3
  • Deserpidine Solution, 100ppm
  • Yohimban-16-carboxylic acid, 17-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-, methyl ester, (3β,16β,17α,18β,20α)-
  • Deserpidine USP/EP/BP
  • Methyl (1S,2R,3R,4aS,13bR,14aS)-2-methoxy-3-((3,4,5-trimethoxybenzoyl)oxy)-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylate
  • 131-01-1