L-Menthol
- Product Name
- L-Menthol
- CAS No.
- 2216-51-5
- Chemical Name
- L-Menthol
- Synonyms
- MENTHOL;Menthol Crystals;(-)-MENTHOL;DL-Menthol menthol crystal extract;(1R,2S,5S)-2-ISOPROPYL-5-METHYL-CYCLOHEXANOL;NATURAL MENTHOL;Mentol Crystal;(R)-(-)-Menthol;L-MENTOL;L(-)-MENTHOL
- CBNumber
- CB7390694
- Molecular Formula
- C10H20O
- Formula Weight
- 156.27
- MOL File
- 2216-51-5.mol
L-Menthol Property
- Melting point:
- 41-45 °C (lit.)
- alpha
- -51 º (589nm, c=10, EtOH)
- Boiling point:
- 212 °C (lit.)
- Density
- 0.89 g/mL at 25 °C (lit.)
- vapor pressure
- 0.8 mm Hg ( 20 °C)
- refractive index
- 1.46
- FEMA
- 2665 | MENTHOL RACEMIC
- Flash point:
- 200 °F
- storage temp.
- Store below +30°C.
- solubility
- 490mg/l
- form
- Crystals or Crystalline Needles
- pka
- 15.30±0.60(Predicted)
- Specific Gravity
- 0.89
- color
- Colorless to white
- Odor
- at 10.00 % in dipropylene glycol. peppermint cooling mentholic minty
- Odor Type
- mentholic
- optical activity
- [α]22/D 49°, c = 10 in 95% ethanol
- Water Solubility
- insoluble
- Merck
- 14,5837
- BRN
- 1902293
- Dielectric constant
- 3.2（Ambient）
- Stability:
- Stable.
- InChIKey
- NOOLISFMXDJSKH-KXUCPTDWSA-N
- LogP
- 3.15 at 25℃
- CAS DataBase Reference
- 2216-51-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Cyclohexanol, 5-methyl-2-(1-methylethyl)-, [1R-(1«alpha»,2«beta»,5«alpha»)]-(2216-51-5)
- EPA Substance Registry System
- Levomenthol (2216-51-5)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 37/38-41-36/37/38
- Safety Statements
- 26-39-37/39-36
- WGK Germany
- 2
- RTECS
- OT0700000
- TSCA
- Yes
- HS Code
- 29061100
- Hazardous Substances Data
- 2216-51-5(Hazardous Substances Data)
- Toxicity
- LD50 orally in Rabbit: 3300 mg/kg LD50 dermal Rabbit > 5000 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- W266590
- Product name
- L-Menthol
- Purity
- ≥99%, FCC, FG
- Packaging
- 1kg
- Price
- $130
- Updated
- 2024/03/01
- Product number
- W266590
- Product name
- L-Menthol
- Purity
- ≥99%, FCC, FG
- Packaging
- 4kg
- Price
- $427
- Updated
- 2024/03/01
- Product number
- W266590
- Product name
- L-Menthol
- Purity
- ≥99%, FCC, FG
- Packaging
- 25kg
- Price
- $2250
- Updated
- 2024/03/01
- Product number
- W266523
- Product name
- L-Menthol
- Purity
- natural, ≥99%, FCC, FG
- Packaging
- 100g
- Price
- $81.9
- Updated
- 2024/03/01
- Product number
- W266523
- Product name
- L-Menthol
- Purity
- natural, ≥99%, FCC, FG
- Packaging
- 1kg
- Price
- $163
- Updated
- 2024/03/01
L-Menthol Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powde
Uses
L-Menthol is used as a cooling agent that strongly activates TRPM8.(Transient Receptor Potential Cation Channel, Subfamily M, Member 8 is a Protein Coding gene). It is used as analgesic (topical), antipruritic agent. It is used as: refreshing agent, food flavor, cool and antipruritic drug, carminative drug. Menthol crystals is used for pers onal care and cosmetics.
Uses
(1R,2S,5R)-(-)-Menthol (L-Menthol) is the natural form of Menthol. L-Menthol is used as: refreshing agent, food flavor, cool and antipruritic drug, carminative drug. Menthol crystals is used for pers onal care and cosmetics.
Definition
ChEBI: A p-menthan-3-ol which has (1R,2S,5R)-stereochemistry. It is the most common naturally occurring enantiomer.
Acquired resistance
(1R,2S,5R)-(-)-Menthol (L-Menthol) is the natural form of Menthol. L- and D-menthol are variants of the same molecule, but have a mirror-image structure in relation to each other, like the right and left hand.
General Description
Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.
Flammability and Explosibility
Non flammable
Biological Activity
l-Menthol inhibite the binding of 13 ligands (calcium channels, sodium channels, γ-aminobutyric acid type A (GABAA) receptor, GABA transporter, dopamine transporter, dopamine D4 receptor, adenosine A2a receptor, α2A-adrenergic receptor, histamine H2 receptor, bombesin receptor, angiotensin AT1 receptor, vasopressin V2 receptor, and leukotriene B4 receptor) with relatively high inhibition rates and acts on these ligands over a similar concentration range. It acts as a positive allosteric modulator of the GABAA receptor rather than an agonist. In periaqueductal grey neurons in rat midbrain slices, l-menthol was shown to prolong spontaneous GABAA receptor–mediated inhibitory current, most likely via a mechanism distinct from that of benzodiazepines. It acts on the dopamine D4 receptor and the dopamine transporter. l-menthol inhibits the [3H]-WIN35,428 binding, similar to GBR12909, suggesting that l-menthol inhibits the binding of dopamine to the dopamine transporter and leading to decreased dopamine uptake[1].
Biochem/physiol Actions
Taste at 25 ppm
Safety Profile
Poison by intravenous route. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. An eye irritant. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
Purification Methods
Crystallise menthol from CHCl3,pet ether or EtOH/water. [Barrow & Atkinson J Chem Soc 638 1939, Beilstein 6 III 133, 6 IV 150.]
References
[1] Umezu T, et al. Identification of novel target molecules of l-menthol. Heliyon, 2021; 7: e07329.
L-Menthol Preparation Products And Raw materials
Raw materials
Preparation Products
L-Menthol Suppliers
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View Lastest Price from L-Menthol manufacturers
- Product
- L-Menthol 2216-51-5
- Price
- US $8.00-0.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- L-Menthol 2216-51-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2023-12-21
- Product
- L-Menthol 2216-51-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99
- Supply Ability
- 200mt/year
- Release date
- 2024-03-19