ChemicalBook > CAS DataBase List > VERATRIDINE

VERATRIDINE

Product Name
VERATRIDINE
CAS No.
71-62-5
Chemical Name
VERATRIDINE
Synonyms
NSC 7524;ybenzoate);Veratrdine;VERATRIDINE;Veratridine-RM;,4alpha,16beta)-;Veratridine, >=98%;veratrine(amorphous);VERATRIDINE FREE BASE;3-VERATROYLVERACEVINE
CBNumber
CB1156432
Molecular Formula
C36H51NO11
Formula Weight
673.79
MOL File
71-62-5.mol
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VERATRIDINE Property

Melting point:
180℃
alpha 
D20 +8.0° (ethanol)
Boiling point:
689.74°C (rough estimate)
Density 
1.45±0.1 g/cm3 (20 ºC 760 Torr)
refractive index 
1.6630 (estimate)
storage temp. 
-20°C
solubility 
ethanol: 50 mg/mL
form 
powder
pka
9.54(at 25℃)
color 
white to off-white
Merck 
13,10016
BRN 
78875
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
EPA Substance Registry System
Veratridine (71-62-5)
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Safety

Hazard Codes 
T+
Risk Statements 
26/27/28-36/37/38-62-52/53-48/20
Safety Statements 
26-36/37/39-45-61-36/37-28
RIDADR 
UN 1544 6.1/PG 1
WGK Germany 
2
RTECS 
YX5600000
F 
10
HazardClass 
6.1(a)
PackingGroup 
II
Hazardous Substances Data
71-62-5(Hazardous Substances Data)
Toxicity
LD50 in mice (mg/kg): 1.35 i.p. (Swiss, Bauer); 0.42 i.v. (Krayer); 6.3 s.c. (Tanaka)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
V5754
Product name
Veratridine
Purity
≥90% (HPLC), powder
Packaging
10mg
Price
$241
Updated
2024/03/01
Sigma-Aldrich
Product number
676950-M
Product name
Veratridine - CAS 71-62-5 - Calbiochem
Purity
A Na+ channel opener.
Packaging
5mg
Price
$107
Updated
2024/03/01
Sigma-Aldrich
Product number
676950-M
Product name
Veratridine - CAS 71-62-5 - Calbiochem
Purity
A Na+ channel opener.
Packaging
676950-5MG
Price
$104
Updated
2023/06/20
Alfa Aesar
Product number
J62324
Product name
Veratridine, 97+%
Packaging
50mg
Price
$0
Updated
2021/12/16
Sigma-Aldrich
Product number
V5754
Product name
Veratridine
Purity
≥90% (HPLC), powder
Packaging
25mg
Price
$470
Updated
2024/03/01
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VERATRIDINE Chemical Properties,Usage,Production

Description

This steroidal alkaloid from Veratrum viride was given this name by Bosetti. It is almost certainly identical with the amorphous veratrine isolated by Schmidt and Koppen, Merck, and Wright and Luff. The base is a colourless, amorphous powder which melts over a wide range. It has [α]22D + 8.0° (EtOH) and yields a sulphate nonahydrate which forms colourless silky needles that resinify in air. The nitrate is only sparingly soluble in H2O. The solution of the alkaloid in H2SO4 becomes orange-red and eventually crimson with a blue fluorescence while that in HCI is colourless. Alkaline hydrolysis furnishes veratric acid and cevine.

Uses

Veratridine causes Na+ channels to stay open during a sustained membrane depolarization by abolishing inactivation.?This, in turn, opens voltage-activated calcium channels, thus increasing intracellular calcium content and inducing neurotransmitter release. Alkaloid neurotoxin which depolarizes excitable tissue; used to increase membrane sodium permeability.

Definition

ChEBI: Veratridine is a steroid. It has a role as a sodium channel modulator. It is functionally related to a cevane.

General Description

Veratridine is one of several alkaloids isolated from the seeds of Schoenocaulon officinale and from the rhizome of Veratrum album. The crude extract is called veratrine or sabadilla and contains cevadine, veratridine, cevadilline, sabadine and cevine. It is a neurotoxin, which belongs to the family Liliaceae and genus, Schoenocaulon. Veratridine is soluble in lipid.

Biochem/physiol Actions

Opens voltage-dependent Na+ channels and prevents their inactivation. This, in turn, opens voltage-activated calcium channels, thus increasing intracellular calcium content and inducing neurotransmitter release. Alkaloid neurotoxin which depolarizes excitable tissue; used to increase membrane sodium permeability. Veratridine is cytotoxic to chromaffin cells in vitro.

storage

-20°C

Purification Methods

It is an alkaloid neurotoxin which prevents inactivation of Na+ channels. Its solubility in EtOH is ~5%; and it separates as a pale yellow powder from an ethanolic solution on addition of Et2O. It forms nitrate, sulfate and perchlorate salts. [McKinney et al. Anal Biochem 153 33 1986, Beilstein 21 V/13 709.]

References

Merck., Annalen, 95, 200 (1855)
Schmidt, Koppen., Ber., 9, 1115 (1876)
Wright, Luff.,J. Chem. Soc., 35, 421 (1879)
Bosetti., Arch. Pharm., 221,82 (1883)
Blount., Chem. Zeit., 26,334 (1902)

VERATRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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VERATRIDINE Suppliers

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View Lastest Price from VERATRIDINE manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
VERATRIDINE 71-62-5
Price
US $30.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000kg
Release date
2024-03-26
Hebei Yanxi Chemical Co., Ltd.
Product
VERATRIDINE 71-62-5
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-11-14
Hebei Weibang Biotechnology Co., Ltd
Product
VERATRIDINE 71-62-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25

71-62-5, VERATRIDINERelated Search:

Verteporfin >=94% (HPLC) 2,5-Dimethyl-2,5-hexanediol 1,4-Cyclohexanedimethanol L-Menthol STEARYLAMINE ACETATE Isopropylparaben Pinacol Ethyl 3,4-dihydroxybenzoate N-ETHYL-4-HYDROXYPIPERIDINE VERATRIDINE PERHYDROFLUORENE 4-Hydroxy-3-methylpiperidine ETHYL 3,4-DIMETHOXYBENZOATE 1-Piperidinepropanol N, N-DIMETHYLOCTADECYLAMINE ACETATE VERATRIDINE(RG) VERATRINE 3-(1-METHYL-PIPERIDIN-4-YL)-PROPAN-1-OL

  • 3-VERATROYLVERACEVINE
  • VERATRIDINE
  • ,4alpha,16beta)-
  • 4,9-epoxycevane-3,4,12,14,16,17,20-heptol3-(3,4-dimethoxybenzoate)
  • cevane-3,4,12,14,16,17,20-heptol,4,9-epoxy-,3-(3,4-dimethoxybenzoate),(3beta
  • Veratridine - CAS 71-62-5 - Calbiochem
  • cevane-3-beta,4-alpha,12,14,16-beta,17,20-heptol,4,9-epoxy-,3-(3,4-dimethox
  • veratrine(amorphous)
  • ybenzoate)
  • 4,9-epoxycevane-3beta,4alpha,12,14,16beta,17,20-heptol 3-veratrate
  • VERATRIDINE FREE BASE
  • 4α,9-Epoxy-3β-veratroyloxy-5β-cevan-4β,12,14,16β,17,20-hexaol
  • NSC 7524
  • Veracevine, veratrate
  • Veratridine, >=98%
  • Veratrdine
  • O3-(3,4-Dimethoxybenzoyl)veracevine
  • 1,2,4-triazolo[4,3-a]pyridin-3-ol
  • Cevane-3,4,12,14,16,17,20-heptol, 4,9-epoxy-, 3-(3,4-dimethoxybenzoate), (3β,4α,16β)-
  • Veratridine-RM
  • 71-62-5
  • C36H51NO11
  • C36H51O11
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Monovalent Ion Channels
  • Other Sodium Channel Modulators
  • Ion Channels
  • Voltage-gated Ion Channels
  • Sodium Channel Modulators
  • Ion Channels
  • Alkaloids