VERATRIDINE
- Product Name
- VERATRIDINE
- CAS No.
- 71-62-5
- Chemical Name
- VERATRIDINE
- Synonyms
- NSC 7524;ybenzoate);Veratrdine;VERATRIDINE;,4alpha,16beta)-;Veratridine, >=98%;veratrine(amorphous);VERATRIDINE FREE BASE;3-VERATROYLVERACEVINE;Veracevine, veratrate
- CBNumber
- CB1156432
- Molecular Formula
- C36H51NO11
- Formula Weight
- 673.79
- MOL File
- 71-62-5.mol
VERATRIDINE Property
- Melting point:
- 180℃
- alpha
- D20 +8.0° (ethanol)
- Boiling point:
- 689.74°C (rough estimate)
- Density
- 1.45±0.1 g/cm3 (20 ºC 760 Torr)
- refractive index
- 1.6630 (estimate)
- storage temp.
- -20°C
- solubility
- ethanol: 50 mg/mL
- form
- powder
- pka
- 9.54(at 25℃)
- color
- white to off-white
- Merck
- 13,10016
- BRN
- 78875
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
- EPA Substance Registry System
- Veratridine (71-62-5)
Safety
- Hazard Codes
- T+
- Risk Statements
- 26/27/28-36/37/38-62-52/53-48/20
- Safety Statements
- 26-36/37/39-45-61-36/37-28
- RIDADR
- UN 1544 6.1/PG 1
- WGK Germany
- 2
- RTECS
- YX5600000
- F
- 10
- HazardClass
- 6.1(a)
- PackingGroup
- II
- Hazardous Substances Data
- 71-62-5(Hazardous Substances Data)
- Toxicity
- LD50 in mice (mg/kg): 1.35 i.p. (Swiss, Bauer); 0.42 i.v. (Krayer); 6.3 s.c. (Tanaka)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P262Do not get in eyes, on skin, or on clothing.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- V5754
- Product name
- Veratridine
- Purity
- ≥90% (HPLC), powder
- Packaging
- 10mg
- Price
- $241
- Updated
- 2024/03/01
- Product number
- 676950-M
- Product name
- Veratridine - CAS 71-62-5 - Calbiochem
- Purity
- A Na+ channel opener.
- Packaging
- 5mg
- Price
- $107
- Updated
- 2024/03/01
- Product number
- 676950-M
- Product name
- Veratridine - CAS 71-62-5 - Calbiochem
- Purity
- A Na+ channel opener.
- Packaging
- 676950-5MG
- Price
- $104
- Updated
- 2023/06/20
- Product number
- J62324
- Product name
- Veratridine, 97+%
- Packaging
- 50mg
- Price
- $0
- Updated
- 2021/12/16
- Product number
- V5754
- Product name
- Veratridine
- Purity
- ≥90% (HPLC), powder
- Packaging
- 25mg
- Price
- $470
- Updated
- 2024/03/01
VERATRIDINE Chemical Properties,Usage,Production
Description
This steroidal alkaloid from Veratrum viride was given this name by Bosetti. It is almost certainly identical with the amorphous veratrine isolated by Schmidt and Koppen, Merck, and Wright and Luff. The base is a colourless, amorphous powder which melts over a wide range. It has [α]22D + 8.0° (EtOH) and yields a sulphate nonahydrate which forms colourless silky needles that resinify in air. The nitrate is only sparingly soluble in H2O. The solution of the alkaloid in H2SO4 becomes orange-red and eventually crimson with a blue fluorescence while that in HCI is colourless. Alkaline hydrolysis furnishes veratric acid and cevine.
Uses
Veratridine causes Na+ channels to stay open during a sustained membrane depolarization by abolishing inactivation.?This, in turn, opens voltage-activated calcium channels, thus increasing intracellular calcium content and inducing neurotransmitter release. Alkaloid neurotoxin which depolarizes excitable tissue; used to increase membrane sodium permeability.
Definition
ChEBI: Veratridine is a steroid. It has a role as a sodium channel modulator. It is functionally related to a cevane.
General Description
Veratridine is one of several alkaloids isolated from the seeds of Schoenocaulon officinale and from the rhizome of Veratrum album. The crude extract is called veratrine or sabadilla and contains cevadine, veratridine, cevadilline, sabadine and cevine. It is a neurotoxin, which belongs to the family Liliaceae and genus, Schoenocaulon. Veratridine is soluble in lipid.
Biochem/physiol Actions
Opens voltage-dependent Na+ channels and prevents their inactivation. This, in turn, opens voltage-activated calcium channels, thus increasing intracellular calcium content and inducing neurotransmitter release. Alkaloid neurotoxin which depolarizes excitable tissue; used to increase membrane sodium permeability. Veratridine is cytotoxic to chromaffin cells in vitro.
storage
-20°C
Purification Methods
It is an alkaloid neurotoxin which prevents inactivation of Na+ channels. Its solubility in EtOH is ~5%; and it separates as a pale yellow powder from an ethanolic solution on addition of Et2O. It forms nitrate, sulfate and perchlorate salts. [McKinney et al. Anal Biochem 153 33 1986, Beilstein 21 V/13 709.]
References
Merck., Annalen, 95, 200 (1855)
Schmidt, Koppen., Ber., 9, 1115 (1876)
Wright, Luff.,J. Chem. Soc., 35, 421 (1879)
Bosetti., Arch. Pharm., 221,82 (1883)
Blount., Chem. Zeit., 26,334 (1902)
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View Lastest Price from VERATRIDINE manufacturers
- Product
- VERATRIDINE 71-62-5
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2000kg
- Release date
- 2024-03-26
- Product
- VERATRIDINE 71-62-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20 tons
- Release date
- 2023-11-14
- Product
- VERATRIDINE 71-62-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-11-17