inulicin
- Product Name
- inulicin
- CAS No.
- 33627-41-7
- Chemical Name
- inulicin
- Synonyms
- inulicin;Britannilactone;inulicin USP/EP/BP;Inulicin, 10 mM in DMSO;Inulicin(1-O-acetyl Britannilactone);1-O-Acetylbritannilactone (Inulicin);6-(3-acetoxy-propyl)-4-hydroxy-5,7-dimethyl-3-methylene-3,3a,4,5,8,8a-hexahydro-cyclohepta[b]furan-2-one;(S)-4-((3aS,4S,7aR)-4-Hydroxy-6-methyl-3-methylene-2-oxo-2,3,3a,4,7,7a-hexahydrobenzofuran-5-yl)pentyl acetate;(3aS)-6-(3-Acetoxypropyl)-3,3aα,4,5,8,8aα-hexahydro-4α-hydroxy-5α,7-dimethyl-3-methylene-2H-cyclohepta[b]furan-2-one;(3aS)-3,3aα,4,5,8,8aα-Hexahydro-4α-hydroxy-6-(3-acetoxypropyl)-5α,7-dimethyl-3-methylene-2H-cyclohepta[b]furan-2-one
- CBNumber
- CB01361911
- Molecular Formula
- C17H24O5
- Formula Weight
- 308.37
- MOL File
- 33627-41-7.mol
inulicin Property
- Melting point:
- 124.0-126.1 °C
- Boiling point:
- 481.7±45.0 °C(Predicted)
- Density
- 1.16
- storage temp.
- 4°C, protect from light
- solubility
- DMSO: soluble
- form
- A solid
- pka
- 13.71±0.60(Predicted)
- color
- White to off-white
- biological source
- plant
- InChI
- InChI=1S/C17H24O5/c1-9(6-5-7-21-12(4)18)14-10(2)8-13-15(16(14)19)11(3)17(20)22-13/h9,13,15-16,19H,3,5-8H2,1-2,4H3/t9-,13+,15+,16+/m0/s1
- InChIKey
- QKUFZFLZBUSEHN-CZLJMHDISA-N
- SMILES
- O1[C@]2([H])CC(C)=C([C@@H](C)CCCOC(C)=O)[C@@H](O)[C@]2([H])C(=C)C1=O
N-Bromosuccinimide Price
- Product number
- 361809
- Product name
- Inulicin
- Packaging
- 10mg
- Price
- $708
- Updated
- 2021/12/16
- Product number
- CS-3742
- Product name
- Inulicin
- Purity
- 99.42%
- Packaging
- 1mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- CS-3742
- Product name
- Inulicin
- Purity
- 99.42%
- Packaging
- 5mg
- Price
- $420
- Updated
- 2021/12/16
- Product number
- PXT0001948
- Product name
- INULICIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.63
- Updated
- 2021/12/16
- Product number
- orb593692
- Product name
- Inulicin
- Packaging
- 5mg
- Price
- $513.4
- Updated
- 2021/12/16
inulicin Chemical Properties,Usage,Production
Uses
Inulicin is a natural product derived from plant source th at finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.
Biological Activity
Inulicin (1-O-Acetylbritannilactone) is an active compound isolated from Inula Britannica L. It inhibits VEGF-mediated activation of Src and FAK. It also inhibits LPS-induced PGE2 production and COX-2 expression, as well as NF-κB activation and translocation.
in vivo
Administration of a single dose of Inulicin (1-O-Acetylbritannilactone; 12 mg/kg/day) remarkably suppresses growth of A549 xenografts in nude mice. In vivo microvessels formation and Src activation are also significantly inhibited in Inulicin-treated xenograft tumors. To investigate the potential activity of Inulicin in vivo, a nude mice xenograft model is applied.
target
| NF-κB < span> | COX-2 td> |
IC 50
NF-κB; COX-2
inulicin Preparation Products And Raw materials
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View Lastest Price from inulicin manufacturers
- Product
- 1-O-Acetylbritannilactone 33627-41-7
- Price
- US $0.00/mg
- Min. Order
- 10mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-04-16