ChemicalBook > CAS DataBase List > 3-(2,4-dimethoxybenzylidene)anabaseine

3-(2,4-dimethoxybenzylidene)anabaseine

Product Name: 3-(2,4-dimethoxybenzylidene)anabaseine
CAS No.: 156223-05-1
Chemical Name: 3-(2,4-dimethoxybenzylidene)anabaseine
Synonyms: DMXB;DMXB-A;DMBX-A;GTS-21HCl;GTS 21 2HCl;GTS-21 (DMXB-A);DMBX-anabaseine;GTS-21 (DMBX-A);GTS 21 2HCl(DMXBA);GTS21;GTS 21;GTS-21
CBNumber: CB01372542
Molecular Formula: C19H22Cl2N2O2
Formula Weight: 0
MOL File: 156223-05-1.mol

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3-(2,4-dimethoxybenzylidene)anabaseine Property

Melting point:: 216-217℃ (decomposition)
storage temp.: 2-8°C
solubility: H2O: >5mg/mL
form: powder
color: faint yellow to dark yellow
Water Solubility: H2O: >5mg/mL
InChIKey: RPYWXZCFYPVCNQ-RVDMUPIBSA-N

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Safety

WGK Germany: 3
RTECS: DW1764860

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0326
Product name: GTS-21
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $88.35
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0326
Product name: GTS-21
Purity: ≥97% (HPLC)
Packaging: 25mg
Price: $380
Updated: 2025/07/31

Sigma-Aldrich

Product number: 5.05277
Product name: GTS-21 Dihydrochloride (DMBX-A) - CAS 156223-05-1 - Calbiochem
Packaging: 10MG
Price: $103
Updated: 2025/07/31

Cayman Chemical

Product number: 21570
Product name: GTS-21 (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $64
Updated: 2024/03/01

Cayman Chemical

Product number: 21570
Product name: GTS-21 (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $113
Updated: 2024/03/01

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3-(2,4-dimethoxybenzylidene)anabaseine Chemical Properties,Usage,Production

Uses

GTS-21 has been used:

as an α7 nicotinic acetylcholine receptors (nAChR) partial agonist to elucidate its anti-inflammatory effects in mouse macrophages
to test its protective effect on the renal injury induced by lipopolysaccharide (LPS)
to test its effect on microvascular inflammation?in endotoxemia induced by LPS

Biochem/physiol Actions

GTS-2, a derivative of anisine is an immunomodulatory drug. It is used for treating pancreatitis and septicemia. GTS-2 inhibits the pro-inflammatory cytokines especially the interleukin-6 (IL6) and tumor necrosis factor (TNF) in sepsis and endotoxemia.

in vivo

GTS 21 (4 mg/kg; i.p.; 1, 3, 7, 14 and 21 days) reduces radiation induced histological signs of pulmonary injury^[3].

Animal Model:	C57BL6 mice were irradiated with 12 Gy to induce a mouse model of Radiation induced lung injury (RILI)^[3]
Dosage:	4 mg/kg
Administration:	I.p.; 1, 3, 7, 14 and 21 days
Result:	Reduces lung inflammatory infiltrate and fibrosis in radiation treated mice.

IC 50

α7-nAChR; human α4β2: 20 nM (Ki); 5-HT_3A Receptor: 3.1 μM (IC₅₀)

3-(2,4-dimethoxybenzylidene)anabaseine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-(2,4-dimethoxybenzylidene)anabaseine manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Gts-21 156223-05-1
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-11-29

Wuhan Haorong Biotechnology Co.,Ltd

Product: Dihydrochloride / 3-(2,4-dimethoxybenzylidene)anabaseine 156223-05-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000
Release date: 2023-08-11

Dingwang Technology (Wuhan) Co., Ltd.

Product: GTS-21 156223-05-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99% min
Supply Ability: 20 tons
Release date: 2022-10-19

156223-05-1, 3-(2,4-dimethoxybenzylidene)anabaseineRelated Search:

2-Methoxyphenylacetic acid 4'-Hydroxyacetophenone Sodium benzoate 3-(2,4-dimethoxybenzylidene)anabaseine

3-(2,4-dimethoxybenzylidene)anabaseine

3-[(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-5,6-dihydro-4H-pyridin-2-yl]pyridine dihydrochloride

3-(2,4-Dimethoxy-benzyl)-3,4,5,6-tetrahydro-[2,3']bipyridinyl

3-(2,4)-DiMethoxybenzylidineanabaseine

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(3E)-3-[(2,4-Dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3'-Bipyridine dihydrochloride

DMBX-anabaseine

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GTS 21 DIHYDROCHLORIDE;DMXB-A;DMBX-ANABASEINE

GTS 21 2HCl(DMXBA)

GTS21;GTS 21;GTS-21

3-(2,4-Dimethoxybenzylidene)-anabaseine dihydrochloride

DMXB

GTS 21 dihydrochloride

3-[(2,4-dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3'-Bipyridine Dihydrochloride

GTS 21 2HCl

GTS 21 2hydrochloride

GTS-21 (hydrochloride)

GTS-21HCl

DMBX-A

(E)-3-(2,4-Dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine dihydrochloride

3-(2,4-dimethoxybenzylidene)anabaseine / 99% / 156223-05-1 in sock

GTS 21 dihydrochloride(DMXB-A)

inhibit,5-hydroxytryptamine Receptor,anti?inflammatory,cognition,GTS-21,nAChR,GTS21 dihydrochloride,Serotonin Receptor,fibrosis,Inhibitor,GTS 21,5-HT Receptor,Nicotinic acetylcholine receptors,lung,injury,GTS21,pulmonary

Dihydrochloride / 3-(2,4-dimethoxybenzylidene)anabaseine

GTS-21 dihydrochloride (DMBX-A)

(E)-3-(2,4-dimethoxybenzylidene)-3,4,5,6-tetrahydro-2,3'-bipyridine hydrochloride

GTS-21 dihydrochloride (DMBX-A), alpha7 Nicotinic acetylcholine receptor agonist

GTS-21 dihydrochloride, 10 mM in DMSO

GTS-21 (DMBX-A)

156223-05-1

C19H22Cl2N2O2

C19H20N2O22HCl

Inhibitors