xanthoangelol

Product Name: xanthoangelol
CAS No.: 62949-76-2
Chemical Name: xanthoangelol
Synonyms: xanthoangelol;Xanthoangelol, 10 mM in DMSO;(E)-1-[3-[(E)-3,7-Dimethyl-2,6-octadienyl]-2,4-dihydroxyphenyl]-3-(4-hydroxyphenyl)-2-propen-1-one;(E)-1-(3-((E)-3,7-Dimethylocta-2,6-dien-1-yl)-2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one;2-Propen-1-one, 1-[3-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-2,4-dihydroxyphenyl]-3-(4-hydroxyphenyl)-, (2E)-
CBNumber: CB01383931
Molecular Formula: C25H28O4
Formula Weight: 392.49
MOL File: 62949-76-2.mol

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xanthoangelol Property

Melting point:: 141-143 °C
Boiling point:: 605.8±55.0 °C(Predicted)
Density: 1.165±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
form: Solid
pka: 7.57±0.50(Predicted)
color: Light yellow to yellow
InChI: InChI=1S/C25H28O4/c1-17(2)5-4-6-18(3)7-13-21-24(28)16-14-22(25(21)29)23(27)15-10-19-8-11-20(26)12-9-19/h5,7-12,14-16,26,28-29H,4,6,13H2,1-3H3/b15-10+,18-7+
InChIKey: LRSMBOSQWGHYCW-MDGZPELGSA-N
SMILES: C(C1=CC=C(O)C(C/C=C(\C)/CC/C=C(/C)\C)=C1O)(=O)/C=C/C1=CC=C(O)C=C1
LogP: 7.240 (est)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0087769
Product name: Xanthoangelol
Purity: 98.36%
Packaging: 1mg
Price: $600
Updated: 2021/12/16

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xanthoangelol Chemical Properties,Usage,Production

Uses

Xanthoangelol, extracted from Angelica keiskei, suppresses obesity-induced inflammatory responses. Xanthoangelol possesses antibacterial activity. Xanthoangelol inhibits monoamine oxidases. Xanthoangelol induces apoptosis in neuroblastoma and leukemia cells[1][2][3][4].

in vivo

Xanthoangelol (0.1% or 0.15% w/w, mixed in a high-fat diet, daily for 14 weeks) suppresses inflammatory mediators in WAT of diet-induced obese mice^[1].

Animal Model:	High-fat diet-induced obese (DIO) mice^[1]
Dosage:	0.1% or 0.15% w/w
Administration:	mixed in a high-fat diet, daily for 14 weeks
Result:	Showed fewer positively stained macrophages, suppressed the gene expression of inflammatory marker MCP-1 and TNF-a, increased oxygen consumption in DIO mice.

References

[1] Li Y, et al. Xanthoangelol and 4-hydroxyderrcin suppress obesity-induced inflammatory responses. Obesity (Silver Spring). 2016 Nov;24(11):2351-2360. DOI:10.1002/oby.21611
[2] Inamori Y, et al. Antibacterial activity of two chalcones, xanthoangelol and 4-hydroxyderricin, isolated from the root of Angelica keiskei KOIDZUMI. Chem Pharm Bull (Tokyo). 1991 Jun;39(6):1604-5. DOI:10.1248/cpb.39.1604
[3] Kim JH, et al. Xanthoangelol and 4-Hydroxyderricin Are the Major Active Principles of the Inhibitory Activities against Monoamine Oxidases on Angelica keiskei K. Biomol Ther (Seoul). 2013 May 30;21(3):234-40. DOI:10.4062/biomolther.2012.100
[4] Keiichi TABATA, et al. Xanthoangelol, a Major Chalcone Constituent of Angelica keiskei, Induces Apoptosis in Neuroblastoma and Leukemia Cells. Biol. Pharm. Bull. 28(8) 1404-1407 (2005).

xanthoangelol Preparation Products And Raw materials

Raw materials

Preparation Products

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xanthoangelol Suppliers

China 54 United States 3 USA 1 Global 58

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xanthoangelol

(E)-1-[3-[(E)-3,7-Dimethyl-2,6-octadienyl]-2,4-dihydroxyphenyl]-3-(4-hydroxyphenyl)-2-propen-1-one

2-Propen-1-one, 1-[3-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-2,4-dihydroxyphenyl]-3-(4-hydroxyphenyl)-, (2E)-

Xanthoangelol, 10 mM in DMSO

(E)-1-(3-((E)-3,7-Dimethylocta-2,6-dien-1-yl)-2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one

62949-76-2