xanthoangelol
- Product Name
- xanthoangelol
- CAS No.
- 62949-76-2
- Chemical Name
- xanthoangelol
- Synonyms
- xanthoangelol;Xanthoangelol, 10 mM in DMSO;(E)-1-[3-[(E)-3,7-Dimethyl-2,6-octadienyl]-2,4-dihydroxyphenyl]-3-(4-hydroxyphenyl)-2-propen-1-one;(E)-1-(3-((E)-3,7-Dimethylocta-2,6-dien-1-yl)-2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one;2-Propen-1-one, 1-[3-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-2,4-dihydroxyphenyl]-3-(4-hydroxyphenyl)-, (2E)-
- CBNumber
- CB01383931
- Molecular Formula
- C25H28O4
- Formula Weight
- 392.49
- MOL File
- 62949-76-2.mol
xanthoangelol Property
- Melting point:
- 141-143 °C
- Boiling point:
- 605.8±55.0 °C(Predicted)
- Density
- 1.165±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- form
- Solid
- pka
- 7.57±0.50(Predicted)
- color
- Light yellow to yellow
- InChI
- InChI=1S/C25H28O4/c1-17(2)5-4-6-18(3)7-13-21-24(28)16-14-22(25(21)29)23(27)15-10-19-8-11-20(26)12-9-19/h5,7-12,14-16,26,28-29H,4,6,13H2,1-3H3/b15-10+,18-7+
- InChIKey
- LRSMBOSQWGHYCW-MDGZPELGSA-N
- SMILES
- C(C1=CC=C(O)C(C/C=C(\C)/CC/C=C(/C)\C)=C1O)(=O)/C=C/C1=CC=C(O)C=C1
- LogP
- 7.240 (est)
N-Bromosuccinimide Price
- Product number
- CS-0087769
- Product name
- Xanthoangelol
- Purity
- 98.36%
- Packaging
- 1mg
- Price
- $600
- Updated
- 2021/12/16
xanthoangelol Chemical Properties,Usage,Production
Uses
Xanthoangelol, extracted from Angelica keiskei, suppresses obesity-induced inflammatory responses. Xanthoangelol possesses antibacterial activity. Xanthoangelol inhibits monoamine oxidases. Xanthoangelol induces apoptosis in neuroblastoma and leukemia cells[1][2][3][4].
in vivo
Xanthoangelol (0.1% or 0.15% w/w, mixed in a high-fat diet, daily for 14 weeks) suppresses inflammatory mediators in WAT of diet-induced obese mice[1].
| Animal Model: | High-fat diet-induced obese (DIO) mice[1] |
| Dosage: | 0.1% or 0.15% w/w |
| Administration: | mixed in a high-fat diet, daily for 14 weeks |
| Result: | Showed fewer positively stained macrophages, suppressed the gene expression of inflammatory marker MCP-1 and TNF-a, increased oxygen consumption in DIO mice. |
References
[1] Li Y, et al. Xanthoangelol and 4-hydroxyderrcin suppress obesity-induced inflammatory responses. Obesity (Silver Spring). 2016 Nov;24(11):2351-2360. DOI:10.1002/oby.21611
[2] Inamori Y, et al. Antibacterial activity of two chalcones, xanthoangelol and 4-hydroxyderricin, isolated from the root of Angelica keiskei KOIDZUMI. Chem Pharm Bull (Tokyo). 1991 Jun;39(6):1604-5. DOI:10.1248/cpb.39.1604
[3] Kim JH, et al. Xanthoangelol and 4-Hydroxyderricin Are the Major Active Principles of the Inhibitory Activities against Monoamine Oxidases on Angelica keiskei K. Biomol Ther (Seoul). 2013 May 30;21(3):234-40. DOI:10.4062/biomolther.2012.100
[4] Keiichi TABATA, et al. Xanthoangelol, a Major Chalcone Constituent of Angelica keiskei, Induces Apoptosis in Neuroblastoma and Leukemia Cells. Biol. Pharm. Bull. 28(8) 1404-1407 (2005).
xanthoangelol Preparation Products And Raw materials
Raw materials
Preparation Products
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