ChemicalBook > CAS DataBase List > 4-hydroxycyclohexylacetic acid

4-hydroxycyclohexylacetic acid

Product Name
4-hydroxycyclohexylacetic acid
CAS No.
99799-09-4
Chemical Name
4-hydroxycyclohexylacetic acid
Synonyms
4-hydroxycyclohexylacetic acid;4-hydroxycyclohexylacetic acidn;4-hydroxy-Cyclohexane acetic acid;Cyclohexaneacetic acid, 4-hydroxy-;2-(4-hydroxycyclohexyl)acetic acid;2-(4-Hydroxycyclohexyl)acetic acid (cis- and trans- );2-(4-Hydroxycyclohexyl)acetic Acid (cis- and trans- mixture)
CBNumber
CB01390786
Molecular Formula
C8H14O3
Formula Weight
158.2
MOL File
99799-09-4.mol
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4-hydroxycyclohexylacetic acid Property

Melting point:
110-120 °C
Boiling point:
326.4±15.0 °C(Predicted)
Density 
1.166±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
4.72±0.10(Predicted)
color 
White to Off-White
InChI
InChI=1S/C8H14O3/c9-7-3-1-6(2-4-7)5-8(10)11/h6-7,9H,1-5H2,(H,10,11)
InChIKey
ALTAAUJNHYWOGS-UHFFFAOYSA-N
SMILES
C1(CC(O)=O)CCC(O)CC1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
H1753
Product name
2-(4-Hydroxycyclohexyl)acetic Acid (cis- and trans- mixture)
Purity
min. 98.0 %(total of isomers)
Packaging
250MG
Price
$52
Updated
2025/07/31
TCI Chemical
Product number
H1753
Product name
2-(4-Hydroxycyclohexyl)acetic Acid (cis- and trans- mixture)
Purity
min. 98.0 %(total of isomers)
Packaging
1G
Price
$128
Updated
2025/07/31
TRC
Product number
H955215
Product name
2-(4-Hydroxycyclohexyl)aceticAcid
Packaging
100mg
Price
$220
Updated
2021/12/16
AK Scientific
Product number
CS-W021411
Product name
2-(4-Hydroxycyclohexyl)aceticacid
Packaging
1g
Price
$143
Updated
2021/12/16
Matrix Scientific
Product number
128007
Product name
2-(4-Hydroxycyclohexyl)aceticacid
Purity
95%
Packaging
1g
Price
$927
Updated
2021/12/16
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4-hydroxycyclohexylacetic acid Chemical Properties,Usage,Production

Uses

2-(4-Hydroxycyclohexyl)acetic Acid can be used to treat cancer and immunological and neurological disorders.

Definition

ChEBI: Cis-4-Hydroxycyclohexylacetic acid is a hydroxy monocarboxylic acid.

Synthesis

99183-13-8

99799-09-4

General procedure for the synthesis of 4-hydroxycyclohexylacetic acid from methyl (4-hydroxycyclohexyl)acetate: potassium hydroxide (326 mg) and methyl 2-(4-hydroxycyclohexyl)acetate (500 mg) were dissolved in a mixed solvent of methanol (20 mL) and water (20 mL), and the reaction was stirred for 6 hours at 60 °C. After completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure to remove most of the solvent. Subsequently, the pH was adjusted to 1 with 2 M hydrochloric acid solution, followed by extraction with ethyl acetate (50 mL). The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 4-hydroxycyclohexylacetic acid (150 mg) as a white solid. Mass spectrometry (ESI) analysis showed that the theoretical molecular weight of C8H14O3 was 158 and the measured value was 159 [M+H]+.

References

[1] Patent: WO2015/180613, 2015, A1. Location in patent: Page/Page column 16
[2] Patent: WO2015/180612, 2015, A1. Location in patent: Page/Page column 43

4-hydroxycyclohexylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-hydroxycyclohexylacetic acid manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
4-hydroxycyclohexylacetic acid 99799-09-4
Price
US $3.00-9.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-06-24
Shanghai Yongzeng Technology Co.,Ltd
Product
2-(4-Hydroxycyclohexyl)acetic acid 99799-09-4
Price
US $0.00/gm
Min. Order
100gm
Purity
99%min
Supply Ability
100kgs
Release date
2024-09-03
Pharmahands (Taizhou) Co., Ltd.
Product
4-hydroxycyclohexylacetic acid 99799-09-4
Price
US $60.00/Kg/Bag
Min. Order
1g
Purity
99%
Supply Ability
50kg/month
Release date
2020-10-30

99799-09-4, 4-hydroxycyclohexylacetic acidRelated Search:


  • 4-hydroxycyclohexylacetic acid
  • 2-(4-hydroxycyclohexyl)acetic acid
  • 4-hydroxy-Cyclohexane acetic acid
  • Cyclohexaneacetic acid, 4-hydroxy-
  • 2-(4-Hydroxycyclohexyl)acetic Acid (cis- and trans- mixture)
  • 4-hydroxycyclohexylacetic acidn
  • 2-(4-Hydroxycyclohexyl)acetic acid (cis- and trans- )
  • 99799-09-4