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AC-SER-LEU-VAL-OH

Product Name
AC-SER-LEU-VAL-OH
CAS No.
189109-90-8
Chemical Name
AC-SER-LEU-VAL-OH
Synonyms
AC-SER-LEU-VAL;AC-SER-LEU-VAL-OH;FAS C-TERMINAL TRIPEPTIDE;L-Valine, N-acetyl-L-seryl-L-leucyl- (9CI)
CBNumber
CB0139955
Molecular Formula
C16H29N3O6
Formula Weight
359.42
MOL File
189109-90-8.mol
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AC-SER-LEU-VAL-OH Property

Boiling point:
725.1±60.0 °C(Predicted)
Density 
1.180±0.06 g/cm3(Predicted)
storage temp. 
-15°C
solubility 
insoluble in H2O; ≥10.04 mg/mL in EtOH; ≥35.9 mg/mL in DMSO
form 
solid
pka
3.36±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology
Product number
A1029
Product name
FasC-TerminalTripeptide
Packaging
1mg
Price
$60
Updated
2021/12/16
ApexBio Technology
Product number
A1029
Product name
FasC-TerminalTripeptide
Packaging
5mg
Price
$180
Updated
2021/12/16
Biorbyt Ltd
Product number
orb364620
Product name
Fas C-Terminal Tripeptide
Purity
> 95%
Packaging
1mg
Price
$353.6
Updated
2021/12/16
ApexBio Technology
Product number
A1029
Product name
FasC-TerminalTripeptide
Packaging
25mg
Price
$420
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PEP0011664
Product name
AC-SER-LEU-VAL
Purity
95.00%
Packaging
5MG
Price
$502.01
Updated
2021/12/16
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AC-SER-LEU-VAL-OH Chemical Properties,Usage,Production

Biological Activity

fas c- terminal tripeptide,(c16h29n3o6), a tri-peptide with the sequence ac-ser-leu-val-oh, it’s the c-terminal tripeptide of fas, mw= 359.4. fas (apo-1/cd95) is a cell surface receptor, which is a member of the tumor necrosis factor receptor (tnfr) superfamily, the fas receptor is a death receptor on the surface of cells that leads to programmed cell death (apoptosis). it is one of two apoptosis pathways. fas forms the death-inducing signaling complex (disc) upon ligand binding. upon ensuing death domain (dd) aggregation, the receptor complex is internalized via the cellular endosomal machinery. this allows the adaptor molecule fadd to bind the death domain of fas through its own death domain. fadd also contains a death effector domain (ded) near its amino terminus,which facilitates binding to the ded of fadd-like interleukin-1 beta-converting enzyme (flice), more commonly referred to as caspase-8. flice can then self-activate through proteolytic cleavage into p10 and p18 subunits, two each of which form the active heterotetramer enzyme. active caspase-8 is then released from the disc into the cytosol, where it cleaves other effector caspases, eventually leading to dna degradation, membrane blebbing, and other hallmarks of apoptosis.the c-terminal tripeptide (ac-ser-leu-val-oh) of fas was necessary and sufficient both for binding to the third pdz domain of fap-1 and for inhibiting fas/fap-1 binding.figure1 formula of fas c- terminal tripeptidefigure2 signaling pathway of fas

References

1. Lichter P, Walczak H, Weitz S, Behrmann I, Krammer PH (September 1992). "The human APO-1 (APT) antigen maps to 10q23, a region that is syntenic with mouse chromosome 19". Genomics 14 (1): 179–80.2. Inazawa J, Itoh N, Abe T, Nagata S (November 1992). "Assignment of the human Fas antigen gene (Fas) to 10q24.1". Genomics 14 (3): 821–2.3. Huang B, et al. (1996). "NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain". Nature 384 (6610): 638–41.4. Eberstadt M, et al. (1998). "NMR structure and mutagenesis of the FADD (Mort1) death-effector domain". Nature 392 (6679): 941–5.

AC-SER-LEU-VAL-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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AC-SER-LEU-VAL-OH Suppliers

GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
ApexBio Technology LLC
Tel
+1-832-696-8203
Fax
+1-832-641-3177
Email
info@apexbt.com
Country
United States
ProdList
477
Advantage
60
Nanjing Peptide Biotech Ltd.
Tel
025-025-58361106-805-805 13082558573
Fax
025-58361106-806
Email
liugang@njpeptide.com
Country
China
ProdList
9980
Advantage
55
Chengdu Youngshe Chemical Co., Ltd.
Tel
+86-17380623303 +86-17380623303
Fax
028-62328193
Email
Caroline@youngshechem.com
Country
China
ProdList
4841
Advantage
58
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Fax
0571-87213919
Email
Eric@peptidego.com
Country
China
ProdList
6756
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471 +1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58

189109-90-8, AC-SER-LEU-VAL-OHRelated Search:


  • FAS C-TERMINAL TRIPEPTIDE
  • AC-SER-LEU-VAL-OH
  • AC-SER-LEU-VAL
  • L-Valine, N-acetyl-L-seryl-L-leucyl- (9CI)
  • 189109-90-8
  • C16H29N3O6
  • Apoptosis