AC-SER-LEU-VAL-OH
- Product Name
- AC-SER-LEU-VAL-OH
- CAS No.
- 189109-90-8
- Chemical Name
- AC-SER-LEU-VAL-OH
- Synonyms
- AC-SER-LEU-VAL;AC-SER-LEU-VAL-OH;FAS C-TERMINAL TRIPEPTIDE;L-Valine, N-acetyl-L-seryl-L-leucyl- (9CI);(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-methylbutanoic acid
- CBNumber
- CB0139955
- Molecular Formula
- C16H29N3O6
- Formula Weight
- 359.42
- MOL File
- 189109-90-8.mol
AC-SER-LEU-VAL-OH Property
- Boiling point:
- 725.1±60.0 °C(Predicted)
- Density
- 1.180±0.06 g/cm3(Predicted)
- storage temp.
- -15°C
- solubility
- insoluble in H2O; ≥10.04 mg/mL in EtOH; ≥35.9 mg/mL in DMSO
- form
- solid
- pka
- 3.36±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- A1029
- Product name
- FasC-TerminalTripeptide
- Packaging
- 1mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- A1029
- Product name
- FasC-TerminalTripeptide
- Packaging
- 5mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- orb364620
- Product name
- Fas C-Terminal Tripeptide
- Purity
- > 95%
- Packaging
- 1mg
- Price
- $353.6
- Updated
- 2021/12/16
- Product number
- A1029
- Product name
- FasC-TerminalTripeptide
- Packaging
- 25mg
- Price
- $420
- Updated
- 2021/12/16
- Product number
- PEP0011664
- Product name
- AC-SER-LEU-VAL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.01
- Updated
- 2021/12/16
AC-SER-LEU-VAL-OH Chemical Properties,Usage,Production
Uses
Fas C-Terminal Tripeptide is a C-terminal tripeptide of Fas. Fas C-Terminal Tripeptide shows the inhibitory effect on Fas/FAP-1 binding[1].
Biological Activity
fas c- terminal tripeptide,(c16h29n3o6), a tri-peptide with the sequence ac-ser-leu-val-oh, it’s the c-terminal tripeptide of fas, mw= 359.4. fas (apo-1/cd95) is a cell surface receptor, which is a member of the tumor necrosis factor receptor (tnfr) superfamily, the fas receptor is a death receptor on the surface of cells that leads to programmed cell death (apoptosis). it is one of two apoptosis pathways. fas forms the death-inducing signaling complex (disc) upon ligand binding. upon ensuing death domain (dd) aggregation, the receptor complex is internalized via the cellular endosomal machinery. this allows the adaptor molecule fadd to bind the death domain of fas through its own death domain. fadd also contains a death effector domain (ded) near its amino terminus,which facilitates binding to the ded of fadd-like interleukin-1 beta-converting enzyme (flice), more commonly referred to as caspase-8. flice can then self-activate through proteolytic cleavage into p10 and p18 subunits, two each of which form the active heterotetramer enzyme. active caspase-8 is then released from the disc into the cytosol, where it cleaves other effector caspases, eventually leading to dna degradation, membrane blebbing, and other hallmarks of apoptosis.the c-terminal tripeptide (ac-ser-leu-val-oh) of fas was necessary and sufficient both for binding to the third pdz domain of fap-1 and for inhibiting fas/fap-1 binding.figure1 formula of fas c- terminal tripeptidefigure2 signaling pathway of fas
References
1. Lichter P, Walczak H, Weitz S, Behrmann I, Krammer PH (September 1992). "The human APO-1 (APT) antigen maps to 10q23, a region that is syntenic with mouse chromosome 19". Genomics 14 (1): 179–80.2. Inazawa J, Itoh N, Abe T, Nagata S (November 1992). "Assignment of the human Fas antigen gene (Fas) to 10q24.1". Genomics 14 (3): 821–2.3. Huang B, et al. (1996). "NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain". Nature 384 (6610): 638–41.4. Eberstadt M, et al. (1998). "NMR structure and mutagenesis of the FADD (Mort1) death-effector domain". Nature 392 (6679): 941–5.
AC-SER-LEU-VAL-OH Preparation Products And Raw materials
Raw materials
Preparation Products
AC-SER-LEU-VAL-OH Suppliers
- Tel
- 21-61263452 13641803416
- Fax
- 86-21-61263399
- ymbetter@glbiochem.com
- Country
- China
- ProdList
- 9981
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 15402
- Advantage
- 60
- Tel
- 025-58361106-805 15951641583
- Fax
- 025-58361106-806
- zhao.xu@njpeptide.com
- Country
- China
- ProdList
- 9979
- Advantage
- 55
- Tel
- +86-17380623303
- Fax
- 028-62328193
- Caroline@youngshechem.com
- Country
- China
- ProdList
- 4802
- Advantage
- 58
- Tel
- 0571-87213919
- Eric@peptidego.com
- Country
- China
- ProdList
- 7408
- Advantage
- 58
- Tel
- meitaochem@126.com
- meitaochem@126.com
- Country
- China
- ProdList
- 19103
- Advantage
- 58
- Tel
- +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
- Tel
- 0571-88211921
- sales1@gotopbio.com
- Country
- CHINA
- ProdList
- 2609
- Advantage
- 58
- Tel
- +86-0371-86658258 +8613203830695
- Fax
- 0371-86658258
- laboratory@coreychem.com
- Country
- China
- ProdList
- 30229
- Advantage
- 58
- Tel
- 0510-85629785 18013409632
- Fax
- 0510-85625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 14081
- Advantage
- 58
- Tel
- 15397062932
- sales1@gotopbio.com
- Country
- China
- ProdList
- 2923
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 021-61109150
- Fax
- 021-61105897
- sales@tcisct.com
- Country
- China
- ProdList
- 29668
- Advantage
- 58
- Tel
- 13675144456
- alan.chow@synzest.com
- Country
- China
- ProdList
- 9470
- Advantage
- 58
- Tel
- 18168071971
- support@yuan-peptide.com
- Country
- China
- ProdList
- 2983
- Advantage
- 58
- Tel
- 0571-0571-88211921 19105816207
- sales4@gotopbio.com
- Country
- China
- ProdList
- 5144
- Advantage
- 58
- Tel
- 0571-87213919 17306812703
- 3007955328@qq.com
- Country
- China
- ProdList
- 6979
- Advantage
- 58
- Tel
- 0571-85350119 15888826472
- 15888826472@163.com
- Country
- China
- ProdList
- 2729
- Advantage
- 58
- Tel
- 15318089928
- alex@hanhonggroup.com
- Country
- China
- ProdList
- 4604
- Advantage
- 58
- Tel
- 13770887460
- wenxi@jszkhy.com
- Country
- China
- ProdList
- 1354
- Advantage
- 58
- Tel
- 17751201929
- office@combiosz.com
- Country
- China
- ProdList
- 3000
- Advantage
- 58
- Tel
- 021-54306202 18917919676
- info@hanhongsci.com
- Country
- China
- ProdList
- 29995
- Advantage
- 58
- Tel
- 13053322091
- admin@mopaikeji.com
- Country
- China
- ProdList
- 5830
- Advantage
- 58
- Tel
- 0571-88211951 13735575465
- sales1@gotopbio.com
- Country
- China
- ProdList
- 4880
- Advantage
- 58
- Tel
- 19135651983
- 18611134419@163.com
- Country
- China
- ProdList
- 4416
- Advantage
- 58
- Tel
- 0571-85350119 15888826472
- bptsales@163.com
- Country
- China
- ProdList
- 3834
- Advantage
- 58
- Tel
- 029-029-81148929 17791530722
- 1049@dideu.com
- Country
- China
- ProdList
- 10011
- Advantage
- 58
- Tel
- 021-52230280 18717909882
- fkuebdpe@163.com
- Country
- China
- ProdList
- 339
- Advantage
- 58
- Tel
- Enzo Biochem Inc. 13797054060
- Enzoname@qq.com
- Country
- China
- ProdList
- 6174
- Advantage
- 58
- Tel
- 51288865780
- sales@biosynth.com
- Country
- China
- ProdList
- 6051
- Advantage
- 58
- Tel
- 400-025-6535
- sales@adooq.cn
- Country
- China
- ProdList
- 6215
- Advantage
- 58
- Tel
- 17320513646
- anna@molcoo.com
- Country
- China
- ProdList
- 3268
- Advantage
- 58
- Tel
- 0512-67583809
- sales@cohesionbio.com
- Country
- China
- ProdList
- 6282
- Advantage
- 58
- Tel
- 17342063383
- sales@allpeptide.com
- Country
- China
- ProdList
- 5320
- Advantage
- 58
- Tel
- +86-17320513646 +8617320513646
- anna@molcoo.com
- Country
- China
- ProdList
- 10000
- Advantage
- 58
- Tel
- +8613854236000
- grant@forestchem.freeqiye.com
- Country
- China
- ProdList
- 752
- Advantage
- 58
- Tel
- +8619375158599
- info@molchanges.com
- Country
- China
- ProdList
- 5218
- Advantage
- 58
- Tel
- +86-755-89396905 +86-15013857715
- admin@nexconn.com
- Country
- China
- ProdList
- 10405
- Advantage
- 58
- Tel
- 19928332050
- Country
- CHINA
- ProdList
- 161
- Advantage
- 58
- Tel
- 18664742264
- Country
- CHINA
- ProdList
- 151
- Advantage
- 58
- Tel
- 15571990006
- Country
- CHINA
- ProdList
- 141
- Advantage
- 58
- Tel
- 13251428727， 13368356747
- Country
- CHINA
- ProdList
- 157
- Advantage
- 58
- Tel
- 18617181553
- Country
- CHINA
- ProdList
- 112
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@neobioscience.com
- Country
- CHINA
- ProdList
- 6207
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenjw@absin.cn
- Country
- CHINA
- ProdList
- 6208
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1920192055@qq.com
- Country
- CHINA
- ProdList
- 1843
- Advantage
- 58
- Tel
- --
- Fax
- --
- SHYIJIEBIO@126.COM
- Country
- CHINA
- ProdList
- 3510
- Advantage
- 58
- Tel
- --
- Fax
- --
- 847627550@qq.com
- Country
- CHINA
- ProdList
- 6087
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- CHINA
- ProdList
- 6829
- Advantage
- 58