(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine

Product Name: (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine
CAS No.: 60419-23-0
Chemical Name: (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine
Synonyms: (R)-1-(2-Pyrrolidinylmeth;(2R)-2-(1-Pyrrolidinylmethyl)pyrrolidine;(R)-1-(Pyrrolidin-2-ylMethyl)pyrrolidine;1-[(2R)-2-Pyrrolidinylmethyl]pyrrolidine;(R)-2-(Pyrrolidin-1-ylmethyl)pyrrolidine;1-(((R)-pyrrolidin-2-yl)methyl)pyrrolidine;(R)-(-)-1-(2-PYRROLIDINYLMETHYL)PYRROLIDINE;Pyrrolidine, 1-[(2R)-2-pyrrolidinylmethyl]-;1-[[(2R)-pyrrolidin-2-yl]methyl]pyrrolidine;(R)-2-(Pyrrolidin-1-ylmethyl)pyrrolidine 2HCl
CBNumber: CB0140975
Molecular Formula: C9H18N2
Formula Weight: 154.25
MOL File: 60419-23-0.mol

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(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine Property

Boiling point:: 265.8±0.0 °C(Predicted)
Density: 0.975±0.06 g/cm3(Predicted)
refractive index: 1.4850 to 1.4890
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: clear liquid
pka: 10.91±0.10(Predicted)
color: Colorless to Light yellow
InChI: InChI=1S/C9H18N2/c1-2-7-11(6-1)8-9-4-3-5-10-9/h9-10H,1-8H2/t9-/m1/s1
InChIKey: YLBWRMSQRFEIEB-SECBINFHSA-N
SMILES: N1(C[C@H]2CCCN2)CCCC1
CAS DataBase Reference: 60419-23-0

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: P1925
Product name: (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $167
Updated: 2023/06/20

TRC

Product number: P999240
Product name: (R)-2-(Pyrrolidin-1-ylmethyl)pyrrolidine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: P999240
Product name: (R)-2-(Pyrrolidin-1-ylmethyl)pyrrolidine
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR913029
Product name: (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine
Purity: 95%
Packaging: 1g
Price: $120
Updated: 2021/12/16

Activate Scientific

Product number: AS30153
Product name: (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine
Purity: 98+% ee
Packaging: 1g
Price: $164
Updated: 2021/12/16

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(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine Chemical Properties,Usage,Production

Synthesis

144243-45-8

60419-23-0

Using (+)-Cbz-D-proline (1.5 g, 6 mmol) as raw material, EDC (2.3 g, 12 mmol), HOBt (800 mg, 6 mmol), TEA (1.5 mL), and pyrrolidine (853 mg, 12 mmol) were sequentially added in DMF (20 mL) and the reaction was stirred at room temperature for 18 hours. After completion of the reaction, the reaction solution was diluted with water and sodium bicarbonate and extracted with dichloromethane (3 x 20 mL). The organic phases were combined, concentrated and purified by silica gel column chromatography to afford benzyl (R)-2-(pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylate. The resulting benzyl ester of (R)-2-(pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylate was dissolved in methanol, Pd/C catalyst was added and hydrogenated at room temperature for 20 h. After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to give pyrrolidin-1-yl-(R)-pyrrolidin-2-yl- methanone. Pyrrolidin-1-yl-(R)-pyrrolidin-2-yl-methanone (1.2 g, 7.1 mmol) was dissolved in THF (10 mL) at 0 °C and B2H6 (10 mL, 10 mmol) was added slowly. The reaction mixture was heated to reflux and reacted for 16 hours. Upon completion of the reaction, the reaction solution was acidified with HCl and concentrated to remove the solvent. The residue was adjusted to pH 10 with 2N NaOH and extracted with dichloromethane solution containing 5% methanol. The organic phases were combined, concentrated and purified by silica gel column chromatography to afford the target product (R)-1-(2-pyrrolidinylmethyl)pyrrolidine 800 mg in 73% yield.

References

[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 23, p. 4334 - 4343
[2] Patent: WO2004/76412, 2004, A2. Location in patent: Page 98
[3] Patent: US2003/125370, 2003, A1
[4] Patent: WO2017/17630, 2017, A1. Location in patent: Page/Page column 50

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine Suppliers

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View Lastest Price from (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine 60419-23-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 1-[(2R)-2-Pyrrolidinylmethyl]pyrrolidine 60419-23-0
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-08-07

60419-23-0, (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidineRelated Search:

Polyvinylpyrrolidone 1-Methylpyrrolidine N-Methyl-2-pyrrolidone Pyrrolidine (R)-Benzyl 2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate PHA-665752 METHYL-2-PYRROLIDONE H-VAL-D-PRO-PRO-OH BOC-ALA-ALA-D-TRP-PHE-D-PRO-PRO-NLE-NH2 ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-D-PRO-PRO-TRP-NH2 BOC-ARG-ALA-D-TRP-PHE-D-PRO-PRO-NLE-NH2 BZ-ALA-ALA-D-TRP-PHE-D-PRO-PRO-NLE-NH2 GR 94800 1-(2-PYRROLIDINYLMETHYL)PYRROLIDINE (R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine FMOC-D-PRO-D-PRO-D-PRO-D-PRO-OH TRIFLUOROACETATE NPC 17731, [PRO-3,4-3H]- (D)-H-GRKKRRQRRRPPRPKRPTTLNLFPQVRRSQDT-NH2

(R)-(-)-1-(2-PYRROLIDINYLMETHYL)PYRROLIDINE

(R)-1-(Pyrrolidin-2-ylMethyl)pyrrolidine

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(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine98%

(R)-2-(Pyrrolidin-1-ylmethyl)pyrrolidine 2HCl

(R)-1-(2-Pyrrolidinylmeth

1-[(2R)-2-Pyrrolidinylmethyl]pyrrolidine

1-(((R)-pyrrolidin-2-yl)methyl)pyrrolidine

(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine&gt

(R)-2-(Pyrrolidin-1-ylmethyl)pyrrolidine dihydrochloride

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(R)-1-(Pyrrolidin-2-ylmethyl)pyrrolidine - [P90712]

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60419-23-0