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GR231118

Product Name
GR231118
CAS No.
158859-98-4
Chemical Name
GR231118
Synonyms
1229U91;GR231118;NEUROPEPTIDE Y ANTAGONIST;M.W. 2352.77 C110H170N34O24;Amide Bridge=Glu2-Dap4*,Dap4-Glu2*;H-ILE-GLU-PRO-DAP-TYR-ARG-LEU-ARG-TYR-NH2;H-Ile-Glu-Pro-Dapa-Tyr-Arg-Leu-Arg-Tyr-NH2;ILE-GLU-PRO-DAPA-TYR-ARG-LEU-ARG-TYR-NH2, CYCLIC (2,4') (2',4) DIAMIDE;Ile-Glu-Pro-Dapa-Tyr-Arg-Leu-Arg-Tyr-NH2, cyclic (2,4') (2',4) diaMide (Dapa : diaMinopropionic acid);1229U91, Neuropeptide Y Antagonist, Ile-Glu-Pro-Dapa-Tyr-Arg-Leu-Arg-Tyr-NH2, cyclic (2,4μ)(2μ,4) diamide
CBNumber
CB0142308
Molecular Formula
C110H170N34O24
Formula Weight
2352.74
MOL File
158859-98-4.mol
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GR231118 Property

Density 
1.47±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
lyophilized powder
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
1486
Product name
GR231118
Packaging
500U
Price
$382
Updated
2021/12/16
Usbiological
Product number
255396
Product name
GR 231118
Packaging
500ug
Price
$678
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PEP0001648
Product name
GR231118
Purity
95.00%
Packaging
0.5MG
Price
$710.33
Updated
2021/12/16
ApexBio Technology
Product number
B6760
Product name
GR231118
Packaging
500ug
Price
$566
Updated
2021/12/16
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GR231118 Chemical Properties,Usage,Production

Uses

GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pKi= 8.8)[1].

IC 50

NPY Y4 receptor

References

[1] E M Parker, et al. GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists. Eur J Pharmacol DOI:10.1016/s0014-2999(98)00171-x
[2] Y Dumont, et al. [(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors. Br J Pharmacol.?2000 Jan;129(1):37-46. DOI:10.1038/sj.bjp.0702983

GR231118 Preparation Products And Raw materials

Raw materials

Preparation Products

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GR231118 Suppliers

China 35 Europe 1 France 1 Germany 3 Switzerland 1 United Kingdom 1 United States 8 USA 1 Global 51
NeoMPS SA
Tel
--
Fax
--
Email
neo@neomps.com
Country
France
ProdList
2083
Advantage
71

158859-98-4, GR231118Related Search:

Butanamide, 3-methyl-N-(4-oxo-4-(propylamino)butyl)- GR231118

  • 1229U91
  • GR231118
  • H-ILE-GLU-PRO-DAP-TYR-ARG-LEU-ARG-TYR-NH2
  • ILE-GLU-PRO-DAPA-TYR-ARG-LEU-ARG-TYR-NH2, CYCLIC (2,4') (2',4) DIAMIDE
  • NEUROPEPTIDE Y ANTAGONIST
  • 1229U91, Neuropeptide Y Antagonist, Ile-Glu-Pro-Dapa-Tyr-Arg-Leu-Arg-Tyr-NH2, cyclic (2,4μ)(2μ,4) diamide
  • M.W. 2352.77 C110H170N34O24
  • Ile-Glu-Pro-Dapa-Tyr-Arg-Leu-Arg-Tyr-NH2, cyclic (2,4') (2',4) diaMide (Dapa : diaMinopropionic acid)
  • L-Tyrosinamide, L-isoleucyl-L-α-glutamyl-L-prolyl-3-amino-L-alanyl-L-tyrosyl-L-arginyl-L-leucyl-L-arginyl-, bimol. (2→4'),(2'→4)-dilactam
  • Amide Bridge=Glu2-Dap4*,Dap4-Glu2*
  • H-Ile-Glu-Pro-Dapa-Tyr-Arg-Leu-Arg-Tyr-NH2
  • 158859-98-4
  • C110H170N34O24
  • Neuropeptide Y
  • Neuropeptide Y and Peptide YY Peptides
  • Peptides
  • Biochemicals and Reagents
  • Amino Acids and Peptides
  • BioChemical
  • peptide
  • Neuropeptide Y (NPY ) receptor