ChemicalBook > CAS DataBase List > Olopatadine hydrochloride

Olopatadine hydrochloride

Product Name: Olopatadine hydrochloride
CAS No.: 140462-76-6
Chemical Name: Olopatadine hydrochloride
Synonyms: OLOPATADINE HCL;Patanol;Olopatadin HCL;OLAPATADINE HCL;Olopatadine Hydrochlorde;ALO4943A;AL-4943A;Opatanol;OLOPATDINEHYDROCHLORIDE;Olatadine hydrochloride
CBNumber: CB0144403
Molecular Formula: C21H24ClNO3
Formula Weight: 373.88
MOL File: 140462-76-6.mol

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Olopatadine hydrochloride Property

Melting point:: 242-245?C
storage temp.: Inert atmosphere,Room Temperature
solubility: H2O: ≥20mg/mL
form: solid
color: White to Light yellow
Water Solubility: H2O: ≥20mg/mL
Merck: 14,6840
BCS Class: 3(CLogP), 1 (LogP)
InChI: InChI=1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-;
InChIKey: HVRLZEKDTUEKQH-NOILCQHBSA-N
SMILES: C(=C1/C2=CC=CC=C2COC2C=CC(CC(=O)O)=CC/1=2)\CCN(C)C.Cl
CAS DataBase Reference: 140462-76-6(CAS DataBase Reference)

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Safety

Hazard Codes: T,N
Risk Statements: 25-50
Safety Statements: 45-61
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
RTECS: HQ4135060
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: O0391
Product name: Olopatadine hydrochloride
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $88.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHR3069
Product name: Olopatadine Hydrochloride
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 300mg
Price: $228
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1478403
Product name: Olopatadine hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 150mg
Price: $556
Updated: 2025/07/31

TCI Chemical

Product number: O0361
Product name: Olopatadine Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $256
Updated: 2025/07/31

Cayman Chemical

Product number: 11999
Product name: Olopatadine (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $37
Updated: 2024/03/01

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Olopatadine hydrochloride Chemical Properties,Usage,Production

Description

Olopatadine hydrochloride is an ophthalmic antihistamine that inhibits release of histamine from mast cells and is a relatively selective histamine H1 antagonist. It inhibits type 1 immediate hypersensitivity reactions. Olopatadine hydrochloride is indicated in the temporary relief of itching caused by allergic conjunctivitis. H1 antagonists have an established and valued place in the symptomatic treatment of various immediate hypersensitivity reactions. In addition, the central properties of some of the series are of therapeutic value for suppressing motion sickness or for sedation.

Chemical Properties

White Solid

Originator

Kyowa Hakko (Japan)

Uses

Dual acting histamine H1-receptor antagonist and mast cell stabilizer. Antiallergic; antihistaminic.

Uses

Olopatadine hydrochloride is a potent, selective antagonist of the H1 histamine receptor (Ki = 16-41.1 nM), with much lower affinities for the H2 and H3 receptors (Ki = 43.4 and 172 μM, respectively). It blocks histamine-induced phosphoinositide turnover in isolated cells (IC50 = 9.5-39.9 nM) and prevents passive cutaneous anaphylaxis in rats (ED50 = 49 μg/kg) and anaphylactic bronchoconstriction in guinea pigs (ID50 = 30 μg/kg). Olopatadine is effective in treating allergic rhinitis and conjunctivitis. It also suppresses itch in patients with well-controlled chronic urticaria. In humans, this antihistamine does not cause cognitive or psychomotor impairment at therapeutic doses.[Cayman Chemical]

Preparation

Olopatadine hydrochloride can be prepared in five steps from the sodium salt of phydroxyphenylacetic acid methyl ester with phthalide.

Definition

ChEBI: Olopatadine hydrochloride is a dibenzooxazepine.

brand name

Patanol (Alcon).

Pharmacokinetics

Olopatadine hydrochloride was launched in the US for use in allergic conjunctivitis. It has a fast onset of action with a long duration of action (due to slow dissociation kinetics) that combines the ability to prevent human conjunctival mast cell mediator release with selective H1-receptor antangonistic activity (greater H3:H1 selectivity than H2:H1 selectivity). In addition, Olopatadine hydrochloride had no inhibition of 5-lipoxygenase, PAF acetyltransferase and thromboxane synthase while interfering with phospholipase A2. It has a presynaptic inhibition of tachykinin release and inhibits bronchial sensory nerves through activation of small conductance calcium activated potassium channels. It was more potent than ketotifen and terfenadine and was effective at inhibition of PAF, LTC4 induced conjunctivitis and TXB2 production. It does not accumulate in the CNS, has a low affinity for H1-receptors in the brain, and significantly inhibits allergen induce sneezing. Olopatadine hydrochloride was more effective in conjuctival than in corneal or the trabecuiar meshwork cells.

Veterinary Drugs and Treatments

Olopatadine HCl is a selective H₁ receptor antagonist and inhibitor of histamine release from mast cells. It is marketed for topical use to alleviate symptoms of allergic conjunctivitis in humans and is thought to be safe for use in children three years of age and older. Olopatadine, upon topical application in humans, was shown to have very limited systemic absorption. It was detectable in the milk of nursing rats, after topical application, and like most medications should be avoided in pregnant or nursing animals.

storage

Desiccate at RT

Olopatadine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Olopatadine hydrochloride Suppliers

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View Lastest Price from Olopatadine hydrochloride manufacturers

Wuhan Haorong Biotechnology Co.,Ltd

Product: Olopatadine HCl 140462-76-6
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000
Release date: 2025-07-09

Wuhan JiyunZen Tech Co., Ltd.

Product: Olopatadine Hydrochloride 140462-76-6
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-06-05

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Olopatadine hydrochloride 140462-76-6
Price: US $0.00-0.00/KG
Min. Order: 100g
Purity: 98%-102%
Supply Ability: 10KGS
Release date: 2021-06-07

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OLOPATADINE HYDROCHLORIDE AND THE INTERMEDIATES

ALO4943A

OLAPATADINE HCL

(Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride

Olopatadine Hydrochloride (150 mg)

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Olopatadine, as Hydrochloride

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Olopatadine hydrochloride, 99%, a selective H1 receptor antagonist

OlopatadineHydrochloride&gt

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Olopatadine HCl (ALO4943A

Olopatadine hydrochlorideQ: What is Olopatadine hydrochloride Q: What is the CAS Number of Olopatadine hydrochloride Q: What is the storage condition of Olopatadine hydrochloride

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Olatadine hydrochloride

Olopatadine hydrochloride, 10 mM in DMSO

Olopatadine HCl - Bio-X ?

140462-76-6

C21H23NO3ClH

C21H23NO3HCl

API

Opatanol, Pataday, Patanase, Allelock

APIs

Olopatadine

Amines

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Pharmaceutical material and intermeidates